Abstract
Head and neck patients requiring complex reconstruction present with inherent challenges, such as presence of saliva, intricate three-dimensional anatomy, varying tissue types (mucosa, bone, skin) and not infrequently prior history of radiation, all of which increase the likelihood of wound healing issues ranging from simple incisional dehiscence to fistulas, hardware complications and delayed flap compromise.
This chapter discusses the evidence-based management of failed wound healing (dehiscence and fistula formation) and site-specific complications in major ablative and reconstructive head and neck surgery, with some additional guidance based upon the author’s own experience. The aim of this chapter is to provide an idea of when to consider ‘going back to the operating room’ and when to stick to conservative management protocols. This chapter focuses primarily upon the management of complications once they have occurred (either at the time of primary surgery or as a secondary approach) but does touch upon preventative measures. There is also an emphasis on addressing underlying causative factors, which can be corrected to encourage spontaneous healing wherever possible. Surgical site infections are discussed in the context of managing wound sinuses and fistulae but not specifically regarding the management of cellulitis and abscess.
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References
Rosen R, Manna B. Wound dehiscence. Treasure Island (FL): StatPearls Publishing; 2021; https://www.ncbi.nlm.nih.gov/books/NBK551712/?report=reader#_NBK551712_pubdet_.
Cade J. Oral Cutaneous Fistulas. eMedicine. 2017. ; https://emedicine.medscape.com/article/1077808-overview#a7.
Khanh NT, Iyer NG. Management of post-operative fistula in head and neck surgery: sweeping it under the carpet? World J Otorhinolaryngol. 2015;5(4):93.
Warnecke A, Averbeck T, Wurster U, Harmening M, Lenarz T, Stover T. Diagnostic relevance of B2-transferrin for the detection of cerebrospinal fluid Fistulas. Arch Otolaryngol Head Neck Surg. 2004;130:1178–84.
Lu Y, Zhang S, Peng C, Yang W, Zhang C, Ren Z. Drain fluid amylase as a predictor of postoperative salivary fistula in cases with benign parotid tumours. BMC Oral Health. 2020;20(1):1–7.
Aydoǧan LB, Kiroǧlu M, Tuncer U, Soylu L. The wound amylase concentration in the prediction of pharyngocutaneous fistula. Otolaryngol Head Neck Surg. 2003;129(4):414–6.
Fielder C, Morton R. Wound amylase estimation and the prediction of pharyngocutaneous fistulae. Clin Otolaryngol Allied Sci. 1989;14(2):101–5.
Larsen L, Schuller D. Wound amylase levels as an early indicator of orocutaneous fistulae. Laryngoscope. 1984;94(10):1302–6.
Kasapo F, Ozmen O, Coskun H, Erisen L, Onart S. Evaluation of amylase levels in the neck drainage and serum for early diagnosis of the pharyngocutaneous fistula Farengokütanöz fistülün erken tanısında boyun drenajı ve serumdaki amilaz. Kulak Burun Bogaz Ihtis Derg. 2009;19(2):67–70.
Crumley R, Smith J. Postoperative chylous fistula prevention and management. Laryngoscope. 1976;86(6):805–13.
Delaney SW, Shi H, Shokrani A, Sinha UK. Management of Chyle Leak after head and neck surgery: review of current treatment strategies. Int J Otolaryngol. 2017;2017:1–12.
Kiong KL, Tan NC, Skanthakumar T, Teo CEH, Soo KC, Tan HK, et al. Salivary fistula: blue dye testing as part of an algorithm for early diagnosis. Laryngoscope Investig Otolaryngol. 2017;2(6):363–8.
Paulinelli RR, Freitas-Junior R, De Souza Rahal RM, De Pádua Oliveira LF, Vilela MHT, Moreira MAR, et al. A prospective randomized trial comparing patent blue and methylene blue for the detection of the sentinel lymph node in breast cancer patients. Rev Assoc Med Bras. 2017;63(2):118–23.
Marshall AH, Jones NS, Robertson IJA. An algorithm for the management of CSF rhinorrhoea illustrated by 36 cases. Rhinology. 1999;37(4):182–5.
Miller WD, Furst IM, Sàndor GKB, Keller MA. A prospective, blinded comparison of clinical examination and computed tomography in deep neck infections. Laryngoscope. 1999;109(11):1873–9.
Narayan M, Limbachiya S, Balasubramanian D, Subramaniam N, Thankappan K, Iyer S. Efficacy of small-volume gastrografin videofluoroscopic screening for detecting pharyngeal leaks following total laryngectomy. J Laryngol Otol. 2020;134(4):350–3.
Carsuzaa F, Capitaine AL, Ferrié JC, Apert V, Tonnerre D, Frasca D, et al. Pharyngocutaneous fistulas after total laryngectomy or pharyngolaryngectomy: place of video-fluoroscopic swallowing study. Head Neck. 2020;42(12):3638–46.
Vermuri N, Karanam L, Manchikanti V, Dandamudi S, Puvvada S, Vemuri V. Imaging review of cerebrospinal fluid leaks. Indian J Radiol Imaging. 2017;27(4):441–6.
Stone JA, Castillo M, Neelon B, Mukherji SK. Evaluation of CSF leaks: high-resolution CT compared with contrast- enhanced CT and radionuclide cisternography. Am J Neuroradiol. 1999;20(4):706–12.
Bollig CA, Spradling CS, Dooley LM, Galloway TL, Jorgensen JB. Impact of perioperative hyperglycemia in patients undergoing microvascular reconstruction. Head Neck. 2018;40(6):1196–206.
Eskander A, Kang S, Tweel B, Sitapara J, Old M, Ozer E, et al. Predictors of complications in patients receiving head and neck free flap reconstructive procedures. Otolaryngol Head Neck Surg (United States). 2018;158(5):839–47.
Raikundalia MD, Fang CH, Spinazzi EF, Vazquez A, Park RC, Baredes S, et al. Impact of diabetes mellitus on head and neck cancer patients undergoing surgery. Otolaryngol Head Neck Surg (United States). 2016;154(2):294–9.
Chen MM, Orosco RK, Harris JP, Porter JB, Rosenthal EL, Hara W, et al. Predictors of readmissions after head and neck cancer surgery: a national perspective. Oral Oncol. 2017;71:106–12.
Goel A, Raghavan G, Long J. Risk factors, causes, and costs of hospital readmission after head and neck cancer surgery reconstruction. JAMA Facial Plas Surg. 2019;21(2):137–45.
Rosko AJ, Birkeland AC, Bellile E, Kovatch KJ, Miller AL, Jaffe CC, et al. Hypothyroidism and wound healing after salvage laryngectomy. Ann Surg Oncol. 2018;25(5):1288–95. https://doi.org/10.1245/s10434-017-6278-4.
Pavlidis ET, Pavlidis TE. Pathophysiological consequences of obstructive jaundice and perioperative management. Hepatobiliary Pancreat Dis Int. 2018;17(1):17–21. https://doi.org/10.1016/j.hbpd.2018.01.008.
Karalis M, Pavlidis T, Psarras K, Ballas K, Zaraboukas T, Rafailidis S, et al. Effect of experimentally induced liver cirrhosis on wound healing of the post-extraction tooth socket in rats. Eur Surg Res. 2008;40(2):190–6.
Benson EM, Hirata RM, Thompson CB, Ha PK, Fakhry C, Saunders JR, et al. Pharyngocutaneous fistula after total laryngectomy: a single-institution experience, 2001-2012. Am J Otolaryngol - Head Neck Med Surg. 2015;36(1):24–31. https://doi.org/10.1016/j.amjoto.2014.08.017.
Lebo NL, Caulley L, Alsaffar H, Corsten MJ, Johnson-Obaseki S. Peri-operative factors predisposing to pharyngocutaneous fistula after total laryngectomy: analysis of a large multi-institutional patient cohort. J Otolaryngol Head Neck Surg. 2017;46(1):1–8.
Ĉelikkanat S, Koç C, Akyol MU, özdem C. Effect of blood transfusion on tumor recurrence and postoperative pharyngocutaneous fistula formation in patients subjected to total laryngectomy. Acta Otolaryngol. 1995;115(2):566–8.
Talwar B, Donnelly R, Skelly R, Donaldson M. Nutritional management in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S32–40.
Kerawala CJ, Riva F, Paleri V. The impact of early oral feeding following head and neck free flap reconstruction on complications and length of stay. Oral Oncol. 2021;113(November 2020):105094. https://doi.org/10.1016/j.oraloncology.2020.105094.
Ismael H, Horst M, Farooq M, Jordon J, Patton JH, Rubinfeld IS. Adverse effects of preoperative steroid use on surgical outcomes. Am J Surg. 2011;201(3):305–9. https://doi.org/10.1016/j.amjsurg.2010.09.018.
Kihara A, Kasamaki S, Kamano T, Sakamoto K, Tomiki Y, Ishibiki Y. Abdominal wound dehiscence in patients receiving long-term steroid treatment. J Int Med Res. 2006;34(2):223–30.
Garip M, Van Dessel J, Grosjean L, Politis C, Bila M. The impact of smoking on surgical complications after head and neck reconstructive surgery with a free vascularised tissue flap: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2021;59(3):e79–98. https://doi.org/10.1016/j.bjoms.2020.07.020.
Nolan MB, Warner DO. Safety and efficacy of nicotine replacement therapy in the perioperative period: a narrative review. Mayo Clin Proc. 2015;90(11):1553–61. https://doi.org/10.1016/j.mayocp.2015.08.003.
Fulcher S, Koman L, Smith B, Holden M, Smith T. The effect of transdermal nicotine on digital perfusion in reformed habitual smokers. J Hand Surg [Am]. 1998;23(5):792–9.
Tartari E, Weterings V, Gastmeier P, Rodríguez Baño J, Widmer A, Kluytmans J, et al. Patient engagement with surgical site infection prevention: an expert panel perspective. Antimicrob Resist Infect Control. 2017;6(1):1–9.
Brennan P, Schliephake H, Ghali G, Cascarini L, editors. Maxillofacial surgery. 3rd ed. Churchill Livingstone; 2017.
Llorente JL, Lopez F, Camporro D, Fueyo A, Rial JC, De Leon RF, et al. Outcomes following microvascular free tissue transfer in reconstructing skull base defects. J Neurol Surgery, Part B Skull Base. 2013;74(5):324–30.
Chiu ES, Kraus D, Bui DT, Mehrara BJ, Disa JJ, Bilsky M, et al. Anterior and middle cranial fossa skull base reconstruction using microvascular free tissue techniques: surgical complications and functional outcomes. Ann Plast Surg. 2008;60(5):514–20.
Shiley SG, Limonadi F, Delashaw JB, Barnwell SL, Andersen PE, Hwang PH, et al. Incidence, etiology, and management of cerebrospinal fluid leaks following trans-sphenoidal surgery. Laryngoscope. 2003;113(8):1283–8.
Oh J-W, Kim S-H, Whang K. Traumatic cerebrospinal fluid leak: diagnosis and management. Korean J Neurotrauma. 2017;13(2):63.
Choi EH, Chan AY, Brown NJ, Lien BV, Sahyouni R, Chan AK, et al. Effectiveness of repair techniques for spinal Dural tears: a systematic review. World Neurosurg. 2021;149:140–7. https://doi.org/10.1016/j.wneu.2021.02.079.
Hannan CJ, Kelleher E, Javadpour M. Methods of skull base repair following endoscopic endonasal tumor resection: a review. Front Oncol. 2020;10(August):1–10.
Brodie H. Prophylactic antibiotics for posttraumatic cerebrospinal fluid fistulae: a meta-analysis. Arch Otolaryngol Head Neck Surg. 1997;123(7):749–52.
Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam A, Snyderman CH, et al. A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. 2006;116(10):1882–6.
Haanaes H, Pedersen K. Treatment of oroantral communication. Int J Oral Surg. 1974;3(3):124–32.
Khandelwal P, Hajira N. Management of Oro-antral communication and fistula: various surgical options. World J Plast Surg. 2017;6(1):3–8; http://www.ncbi.nlm.nih.gov/pubmed/28289607%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5339603.
Parvini P, Obreja K, Sader R, Becker J, Schwarz F, Salti L. Surgical options in oroantral fistula management: a narrative review. Int J Implant Dent. 2018;4(1):40.
Ziemba R. Combined buccal and reverse palatal flap for closure of oral-antral fistula. J Oral Surg. 1972;30(10):727–9.
Siegel E, Bechtold W, Sherman P, Stoopack J. Pedicle tongue flap for closure of an oroantral defect after partial maxillectomy. J Oral Surg. 1977;35(9):746–8.
Ragbir M, Brown JS, Mehanna H. Reconstructive considerations in head and neck surgical oncology: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S191–7.
Molteni G, Saccetto A, Saccetto L, Marchioni D. Optimal management of post-laryngectomy pharyngo-cutaneous fistula. Open Access Surg. 2020;13:11–25.
Qureshi SS, Chaturvedi P, Pai PS, Chaukar DA, Deshpande MS, Pathak KA, et al. A prospective study of pharyngocutaneous fistulas following total laryngectomy. J Cancer Res Ther. 2005;1(1):51–6.
Ganly I, Patel S, Matsuo J, Singh B, Kraus D, Boyle J, et al. Postoperative complications of salvage total laryngectomy. Cancer. 2005;103(10):2073–81.
Powell J, Ullal UR, Ahmed O, Ragbir M, Paleri V. Tissue transfer to post-chemoradiation salvage laryngectomy defects to prevent pharyngocutaneous fistula: single-centre experience. J Laryngol Otol. 2014;128(4):365–7.
Kao HK, Abdelrahman M, Chang KP, Wu CM, Hung SY, Shyu VBH. Choice of flap affects fistula rate after salvage laryngopharyngectomy. Sci Rep. 2015;5:1–5.
Sayles M, Grant DG. Preventing pharyngo-cutaneous fistula in total laryngectomy: a systematic review and meta-analysis. Laryngoscope. 2014;124(5):1150–63.
Varvares MA, Cheney ML, Gliklich RE, Boyd JM, Goldsmith T, Lazor J, et al. Use of the radial forearm fasciocutaneous free flap and Montgomery salivary bypass tube for pharyngoesophageal reconstruction. Head Neck. 2000;22(5):463–8.
Patel SY, Meram AT, Kim DD. Soft tissue reconstruction for head and neck ablative defects. Oral Maxillofac Surg Clin N Am. 2019;31(1):39–68.
Yu P, Hanasono MM, Skoracki RJ, Baumann DP, Lewin JS, Weber RS, et al. Pharyngoesophageal reconstruction with the anterolateral thigh flap after total laryngopharyngectomy. Cancer. 2010;116(7):1718–24.
Busoni M, Deganello A, Gallo O. Fistola faringocutanea dopo laringectomia totale: Analisi Dei fattori di rischio, della prognosi e delle modalità di trattamento. Acta Otorhinolaryngol Ital. 2015;35(6):400–5.
Sun W, Ma R-Q, Wen W-P, Zhu X-L. Treatment principle based on the clinical staging of pharyngocutaneous fistula. Int J Otolaryngol. 2020;2020:1.
White HN, Golden B, Sweeny L, Carroll WR, Magnuson JS, Rosenthal EL. Assessment and incidence of salivary leak following laryngectomy. Laryngoscope. 2012;122(8):1796–9.
Bennett MH, Feldmeier J, Hampson NB, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev. 2016;2016(4):CD005005.
Kadapathri A, Munnangi A, Chandrashekar NH, Mohiyuddin A, Pillai V, Vidyabhushan R, et al. An insight into pharyngeal closure techniques during a laryngectomy-can we minimize pharyngocutaneous fistulas ? J Med Dent Sci. 2020;19(6):35–9.
Abu Eta R, Eviatar E, Gavriel H. Hyperbaric oxygen therapy as an alternative to surgery for non-healing pharyngocutaneous fistula. Eur Arch Oto-Rhino-Laryngology. 2016;273(11):3857–61.
Shi Y, Lee CS, Wu J, Koch CJ, Thom SR, Maity A, et al. Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature. Head Neck. 2005;27(5):362–9.
Loaec E, Vaillant PY, Bonne L, Marianowski R. Negative-pressure wound therapy for the treatment of pharyngocutaneous fistula. Eur Ann Otorhinolaryngol Head Neck Dis. 2014;131(6):351–5. https://doi.org/10.1016/j.anorl.2013.12.001.
Inatomi Y, Kadota H, Yoshida S, Kamizono K, Shimamoto R, Fukushima S, et al. Utility of negative-pressure wound therapy for orocutaneous and pharyngocutaneous fistula following head and neck surgery. Head Neck. 2020;42(1):103–10.
Mir A, Guys N, Arianpour K, Svider PF, Rayess H, Zuliani G, et al. Negative pressure wound therapy in the head and neck: an evidence-based approach. Laryngoscope. 2019;129(3):671–83.
Orgill DP, Bayer LR. Update on negative-pressure wound therapy. Plast Reconstr Surg. 2011;127(1S):105–15.
Hawkes AC, Stell PM. Results of closure of pharyngocutaneous fistulae. Clin Otolaryngol Allied Sci. 1980;5(4):249–53.
Fink D, Pena S, Hanby D, Kunduk M, McWhorter A. Repair of pharyngocutaneous fistula after total laryngectomy: a novel endoscopic approach. Head Neck. 2015;37(7):E81–4.
Dunlap Q, Bridges M, Nelson K, King D, Stack BC, Vural E, et al. Predictors for postoperative chyle leak following neck dissection, a technique-based comparison. Otolaryngol - Head Neck Surg (United States). 2021;165(5):667–72.
Brennan PA, Blythe JN, Herd MK, Habib A, Anand R. The contemporary management of chyle leak following cervical thoracic duct damage. Br J Oral Maxillofac Surg. 2012;50(3):197–201. https://doi.org/10.1016/j.bjoms.2011.02.001.
Roh JL, Yoon YH, Il PC. Chyle leakage in patients undergoing thyroidectomy plus central neck dissection for differentiated papillary thyroid carcinoma. Ann Surg Oncol. 2008;15(9):2576–80.
Meyer CD, McLeod IK, Gallagher DJ. Conservative management of an intraoperative chyle leak: a case report and literature review. Mil Med. 2016;181(9):e1180–4.
Yetisir F, Yurekli B, Salman A, Unal M, Acar H, Yildirim M, et al. The impact of harmonic scalpel on complications after neck dissection in papillary thyroid carcinoma: a prospective randomized study. J Thyroid Disord Ther. 2012;01(04):4–7.
Spiro JD, Spiro RH, Strong EW. The management of chyle fistula. Laryngoscope. 1990;100(7):771–4.
Zhengjiang L, Sabesan T, Pingzhang T, Ilankovan V. Omohyoid muscle flap in prevention of Chyle fistula. J Oral Maxillofac Surg. 2007;65(7):1430–2.
Blythe JNSJ, Habib A, Gulati A, Brennan PA. Use of N-butyl-2-cyanoacrylate tissue glue in thoracic duct injury during neck dissection surgery. Br J Oral Maxillofac Surg. 2011;49(6):486–7. https://doi.org/10.1016/j.bjoms.2010.10.012.
Seelig MH, Klingler PJ, Oldenburg WA. Treatment of a postoperative cervical chylous lymphocele by percutaneous sclerosing with povidone-iodine. J Vasc Surg. 1998;27(6):1148–51.
Chen E, Itkin M. Thoracic duct embolization for chylous leaks. Semin Interv Radiol. 2011;28(1):63–74.
Abdel-Galil K, Milton R, McCaul J. High output chyle leak after neck surgery: the role of video-assisted thoracoscopic surgery. Br J Oral Maxillofac Surg. 2009;47(6):478–80.
Bruner TW, Hanasono MM, Skoracki RJ. Radial forearm free flap morbidity: a rare case of a normal preoperative arteriogram and acute intraoperative hand ischemia. Can J Plast Surg. 2011;19(3):102–4.
Varley I, Carter LM, Wales CJ, Warnock N, Whitfield PH. Ischaemia of the hand after harvest of a radial forearm flap. Br J Oral Maxillofac Surg. 2008;46(5):403–5.
Yin Y, Zhang R, Li S, Guo J, Hou Z, Zhang Y. Negative-pressure therapy versus conventional therapy on split-thickness skin graft: a systematic review and meta-analysis. Int J Surg. 2018;November 2017(50):43–8. Available from:. https://doi.org/10.1016/j.ijsu.2017.12.020.
Goodson AM, Kittur MA, Evans PL, Williams EM. Patient-specific, printed titanium implants for reconstruction of mandibular continuity defects: a systematic review of the evidence. J Craniomaxillofac Surg. 2019;47(6):968–76. https://doi.org/10.1016/j.jcms.2019.02.010.
Betz LH, Betz BW. Peronea arteria magna. Pediatr Radiol. 2009;39(9):1016.
Knitschke M, Baumgart AK, Bäcker C, Adelung C, Roller F, Schmermund D, et al. Computed tomography angiography (CTA) before reconstructive jaw surgery using fibula free flap: retrospective analysis of vascular architecture. Diagnostics. 2021;11(10):1865.
Weng C. Comparison of color flow Doppler, angiogram, CT angiogram and time resolved MR angiogram in the preoperative evaluation of lower extremity vascularity for fibular free flap reconstruction. J Otolaryngol Rhinol. 2016;2(1):1–5.
Saydam F, Basaran K, Ceran F, Mert B. Foot ischemia after a free fibula flap harvest: immediate salvage with an interpositional saphenous vein graft. J Craniofac Surg. 2014;25(5):1784–6.
Lin CC, Hsu H, Cheng LF, Wu MS, Chien SH, Tseng GF, et al. Ankle osteoarthritis: a rare complication after free fibular flap harvesting. Formos J Surg. 2015;48(1):17–20. https://doi.org/10.1016/j.fjs.2014.05.005.
Ling XF, Peng X, Samman N. Donor-site morbidity of free fibula and DCIA flaps. J Oral Maxillofac Surg. 2013;71(9):1604–12.
Van Den Heuvel SCM, Van Der Veen FJC, Winters HAH. The effect of flexor hallucis longus harvest on hallux function: a retrospective cross-sectional cohort study. J Plast Reconstr Aesthet Surg. 2014;67(7):986–91. https://doi.org/10.1016/j.bjps.2014.03.005.
Muramatsu K, Ihara K, Kuwabara Y, Fujii K, Taguchi T. Surgical correction of claw toe deformity following harvesting of fibula flaps. Ann Plast Surg. 2010;65(2):161–3.
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Goodson, A., Payne, K., Anand, R., Praveen, P., Parmar, S. (2023). Surgical Site Complications and Management. In: Quimby, A., Parmar, S., Fernandes, R. (eds) Complex Head and Neck Microvascular Surgery . Springer, Cham. https://doi.org/10.1007/978-3-031-38898-9_17
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