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Optimization of the BOLD Hemodynamic Response Function for EEG-FMRI Studies in Epilepsy

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The Latest Developments and Challenges in Biomedical Engineering (PCBEE 2023)

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 746))

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Abstract

Simultaneous EEG-fMRI measurements are used to study epileptic patients in order to localize brain regions associated with interictal epileptiform discharges (IEDs). The common approach to this analysis uses the generalized linear model (GLM) with a canonical hemodynamic response function (HRF) to relate EEG activity to predicted BOLD responses. The study aimed to determine whether the canonical HRF is optimal for IED-induced hotspot fMRI analysis and develop optimized HRFs. The optimization of four HRF models was performed on BOLD responses derived from SPM activation clusters from 36 epileptic patients. The results showed that the optimized HRF models improved the sensitivity of the EEG-fMRI analysis of IED events in epilepsy patients compared to standard HRFs. This was evidenced by an increase in the size, number, and maximum t-score values of activated areas.

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Author information

Authors and Affiliations

  1. Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland

    Nikodem Hryniewicz, Ewa Piątkowska-Janko & Piotr Bogorodzki

  2. Military Institute of Aviation Medicine, Warsaw, Poland

    Rafał Rola

  3. Warsaw University of Technology, Warsaw, Poland

    Kamil Lipiński & Piotr Bogorodzki

  4. National Institute of Oncology, Warsaw, Poland

    Rafał Rola

Authors
  1. Nikodem Hryniewicz
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  2. Rafał Rola
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  3. Kamil Lipiński
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  4. Ewa Piątkowska-Janko
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  5. Piotr Bogorodzki
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Corresponding author

Correspondence to Nikodem Hryniewicz .

Editor information

Editors and Affiliations

  1. Institute of Electronics, Lodz University of Technology, Lodz, Poland

    Paweł Strumiłło

  2. Institute of Electronics, Lodz University of Technology, Lodz, Poland

    Artur Klepaczko

  3. Institute of Electronics, Lodz University of Technology, Lodz, Poland

    Michał Strzelecki

  4. Institute of Materials Science, Lodz University of Technology, Lodz, Poland

    Dorota Bociąga

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Hryniewicz, N., Rola, R., Lipiński, K., Piątkowska-Janko, E., Bogorodzki, P. (2024). Optimization of the BOLD Hemodynamic Response Function for EEG-FMRI Studies in Epilepsy. In: Strumiłło, P., Klepaczko, A., Strzelecki, M., Bociąga, D. (eds) The Latest Developments and Challenges in Biomedical Engineering. PCBEE 2023. Lecture Notes in Networks and Systems, vol 746. Springer, Cham. https://doi.org/10.1007/978-3-031-38430-1_11

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  • DOI: https://doi.org/10.1007/978-3-031-38430-1_11

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-38429-5

  • Online ISBN: 978-3-031-38430-1

  • eBook Packages: EngineeringEngineering (R0)

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