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Morphometry of the Corpus Callosum

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The Corpus Callosum

Abstract

The corpus callosum (CC) is the major pathway connecting the two cerebral hemispheres of the brain. It consists of four parts, the rostrum, genu, body, and splenium. The CC plays a central role in sensory, motor, and cognitive information in cerebral information transferring and integration between the two cerebral hemispheres. The CC has been studied in regard to morphological features with dimensions, age, and sex differences both in health and neuropsychiatric disorders. Quantitative analysis of the CC morphometry is best studied with T1 sequence on midsagittal MRI. It is known that there are sex and age differences in the size of the CC.

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References

  1. Arıncı K, Elhan A. Anatomi 1. Cilt. Ankara: GüneȘ kitapevleri; 2016. p. 309–11.

    Google Scholar 

  2. Yıldırım M. Human anatomy (in Turkish). İstanbul: Nobel Tıp Kitabevleri; 2003. p. 265–6.

    Google Scholar 

  3. Giedd JN, Rumsey JM, Castellanos FX, Rajapakse JC, Kaysen D, Vaituzis AC, Vauss YC, Hamburger SD, Rapoport JL. A quantitative MRI study of the corpus callosum in children and adolescents. Dev Brain Res. 1996;91(2):274–80. https://doi.org/10.1016/0165-3806(95)00193-x.

    Article  CAS  Google Scholar 

  4. Hofer S, Frahm J. Topography of the human corpus callosum revisited—comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. NeuroImage. 2006;32:989–94. https://doi.org/10.1016/j.neuroimage.2006.05.044.

    Article  PubMed  Google Scholar 

  5. Huang H, Zhang J, Jiang H, Wakana S, Poetscher L, Miller MI, Van Zijl PCM, Hillis AE, Wytik R, Mori S. DTI tractography based parcellation of white matter: application to the mid-sagittal morphology of corpus callosum. NeuroImage. 2005;26:195–205.

    Article  PubMed  Google Scholar 

  6. Kurt A. Telencephalon. In: Gövsa Gökmen F, editor. Sistematik anatomi. İzmir: Güven kitabevi; 2003. p. 740–2.

    Google Scholar 

  7. Battal B, Kocaoglu M, Akgun V, Bulakbasi N, Tayfun C. Corpus callosum: normal imaging appearance, variants and pathologic conditions. J Med Imaging Radiat Oncol. 2010;54:541–9. https://doi.org/10.1111/j.1754-9485.2010.02218.x.

    Article  CAS  PubMed  Google Scholar 

  8. Sakai T, Mikami A, Suzuki J, Miyabe-Nishiwaki T, Matsui M, Tomonaga M, Hamada Y, Matsuzawa T, Okano H, Oishi K. Developmental trajectory of the corpus callosum from infancy to the juvenile stage: comparative MRI between chimpanzees and humans. PLoS One. 2017;12(6):e0179624. https://doi.org/10.1371/journal.pone.0179624.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Garel C, Cont I, Alberti C, Josserand E, Moutard ML, Ducou le Pointe H. Biometry of the corpus callosum in children: MR imaging reference data. AJNR Am J Neuroradiol. 2011;32(8):1436–43. https://doi.org/10.3174/ajnr.A2542.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kostovic I, Rakic P. Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain. J Comp Neurol. 1990;297:441–70.

    Article  CAS  PubMed  Google Scholar 

  11. Kostović I, Kostović-Srzentić M, Benjak V, Jovanov-Milošević N, Radoš M. Developmental dynamics of radial vulnerability in the cerebral compartments in preterm infants and neonates. Front Neurol. 2014;5(139):1–13. https://doi.org/10.3389/fneur.2014.00139.

    Article  Google Scholar 

  12. Suganthy J, Raghuram L, Antonisamy B, Vettivel S, Madhavi C, Koshi R. Gender- and age-related differences in the morphology of the corpus callosum. Clin Anat. 2003;16:396–403.

    Article  CAS  PubMed  Google Scholar 

  13. Teipel SJ, Schapiro MB, Alexander GE, Krasuski JS, Horwitz B, Hoehne C, Möller HJ, Rapoport SI, Hampel H. Relation of corpus callosum and hippocampal size to age in nondemented adults with Down’s syndrome. Am J Psychiatry. 2003;160:1870–8.

    Article  PubMed  Google Scholar 

  14. Teipel SJ, Bayer W, Alexander GE, Zebuhr Y, Teichberg D, Kulic L, Schapiro MB, Möller HJ, Rapoport SI, Hampel H. Progression of corpus callosum atrophy in Alzheimer disease. Arch Neurol. 2002;59:243–8. https://doi.org/10.1001/archneur.59.2.243.

    Article  PubMed  Google Scholar 

  15. Tomaiuolo F, Di Paola M, Caravale B, Vicari S, Petrides M, Caltagirone C. Morphology and morphometry of the corpus callosum in Williams syndrome: a T1-weighted MRI study. Neuroreport. 2002;13(17):2281–4. https://doi.org/10.1097/00001756-200212030-00022.

    Article  CAS  PubMed  Google Scholar 

  16. Woldehawariat G, Martinez PE, Hauser P, Hoover DM, Drevets WWC, McMahon FJ. Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions. PLoS One. 2014;9(6):e99980. https://doi.org/10.1371/journal.pone.0099980.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Yasar AS, Monkul ES, Sassi RB, Axelson D, Brambilla P, Nicoletti MA, Hatch JP, Keshavan M, Ryan N, Birmaher B, Soares JC. MRI study of corpus callosum in children and adolescents with bipolar disorder. Psychiatry Res Neuroimaging. 2006;146:83–5. https://doi.org/10.1016/j.pscychresns.2005.09.004.

    Article  Google Scholar 

  18. Zilles K, Kawashima R, Dabringhaus A, Fukuda H, Schormann T. Hemispheric shape of european and japanese brains:3-D MRI analysis of intersubject variability, ethnical, and gender differences. NeuroImage. 2001;13:262–71.

    Article  CAS  PubMed  Google Scholar 

  19. Di Paola M, Spalletta G, Caltagirone C. In vivo structural neuroanatomy of corpus callosum in Alzheimer’s disease and mild cognitive impairment using different MRI techniques: a review. J Alzheimers Dis. 2010;20:67–95. https://doi.org/10.3233/JAD-2010-1370.

    Article  PubMed  Google Scholar 

  20. Di Paola M, Luders E, Cherubini A, Sanchez-Castaneda C, Thompson PM, Toga AW, Caltagirone C, Orobello S, Elifani F, Squitieri F, Sabatini U. Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington’s disease. Cereb Cortex. 2012;22(12):2858–66. https://doi.org/10.1093/cercor/bhr360.

    Article  PubMed  Google Scholar 

  21. Frederiksen KS, Garde E, Skimminge A, Ryberg C, Rostrup E, Baare WFC, Siebner HR, Hejl AM, Leffers AM, Waldemar G. Corpus callosum atrophy in patients with mild Alzheimer’s disease. Neurodegener Dis. 2011;8(6):476–82. https://doi.org/10.1159/000327753.

    Article  PubMed  Google Scholar 

  22. Hasan KM, Walimuni IS, Abid H, Wolinsky JS, Narayana PA. Multi-modal quantitative MRI investigation of brain tissue neurodegeneration in multiple sclerosis. J Magn Reson Imaging. 2012;35(6):1300–11. https://doi.org/10.1002/jmri.23539.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Tomaiuolo F, Scapin M, Di Paola M, Le Nezet P, Fadda L, Musicco M, Caltagirone C, Collins DL. Gross anatomy of the corpus callosum in Alzheimer’s disease: regions of degeneration and their neuropsychological correlates. Dement Geriatr Cogn Disord. 2007;23:96–103. https://doi.org/10.1159/000097371.

    Article  CAS  PubMed  Google Scholar 

  24. Bearden CE, van Erp TGM, Dutton RA, Boyle C, Madsen S, Luders E, Kieseppa T, Tuulio-Henriksson A, Huttunen M, Partonen T, Kaprio J, Lönnqvist J, Thompson PM, Cannon TD. Mapping corpus callosum morphology in twin pairs discordant for bipolar disorder. Cereb Cortex. 2011;21(10):2415–24. https://doi.org/10.1093/cercor/bhr030.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Sun J, Maller JJ, Daskalakis ZJ, Furtado CC, Fitzgerald PB. Morphology of the corpus callosum in treatment-resistant schizophrenia and major depression. Acta Psychiatr Scand. 2009;120(4):265–73. https://doi.org/10.1111/j.1600-0447.2009.01389.x.

    Article  CAS  PubMed  Google Scholar 

  26. Walterfang M, Yücel M, Barton S, Reutens DC, Wood AG, Chen J, Lorenzetti V, Velakoulis D, Pantelis C, Allen NB. Corpus callosum size and shape in individuals with current and past depression. J Affect Disord. 2009;115(3):411–20. https://doi.org/10.1016/j.jad.2008.10.010.

    Article  PubMed  Google Scholar 

  27. Hampel H, Teipel SJ, Alexander GE, Pogarell O, Rapoport SI, Möller HJ. In vivo imaging of region and cell type specific neocortical neurodegeneration in Alzheimer’s disease. Perspectives of MRI derived corpus callosum measurement for mapping disease progression and effects of therapy. Evidence from studies with MRI, EEG and PET. J Neural Transm. 2002;109:837–55.

    Article  CAS  PubMed  Google Scholar 

  28. Marcus DS, Fotenos AF, Csernansky JG, Morris JC, Buckner RL. Open access series of imaging studies (OASIS): longitudinal MRI data in nondemented and demented older adults. J Cogn Neurosci. 2010;22(12):2677–84. https://doi.org/10.1162/jocn.2009.21407.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Lyoo IK, Satlin A, Lee CK, Renshaw PF. Regional atrophy of the corpus callosum in subjects with Alzheimer’s disease and multi-infarct dementia. Psychiatry Res. 1997;74(2):63–72. https://doi.org/10.1016/s0925-4927(97)00009-7.

    Article  CAS  PubMed  Google Scholar 

  30. Weis S, Kimbacher M, Wenger E, Neuhold A. Morphometric analysis of the corpus callosum using MR: correlation of measurements with aging in healthy individuals. AJNR Am J Neuroradiol. 1993;14:637–45.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum. Brain. 1989;112:799–835.

    Article  PubMed  Google Scholar 

  32. Anderson NG, Laurent I, Woodward LJ, Inder TE. Detection of impaired growth of the corpus callosum in premature infants. Pediatrics. 2006;118(3):951–60. https://doi.org/10.1542/peds.2006-0553.

    Article  PubMed  Google Scholar 

  33. Habibi HA, Gül OB, Öztürk M, Çalışkan E. Morphometric analysis of corpus callosum with magnetic resonance imaging in children; correlation with age and gender. İzmir Dr Behçet Uz Çocuk Dergisi. 2021;11(3):277–85. https://doi.org/10.5222/buchd.2021.93709.

    Article  Google Scholar 

  34. Hwang SJ, Ji EK, Lee EK, Kim YM, Shin DY, Cheon YH, Rhyu IJ. Gender differences in the corpus callosum of neonates. Neuroreport. 2004;15(6):1029–32.

    Article  PubMed  Google Scholar 

  35. Matteson SR, Deahl ST, Alder ME, Nummikoski PV. Advanced İmagıng methods. Crit Rev Oral Biol Med. 1996;7(4):346–95.

    Article  CAS  PubMed  Google Scholar 

  36. Ho ML, Moonis G, Ginat DT, Eisenberg RL. Lesions of the corpus callosum. AJR 2013;200:W1-W16 0361–803X/13/2001–W1. https://doi.org/10.2214/AJR.11.8080.

  37. Tavlayan E, Olacak N, Yavuz A. Beyin tümörlerinin radyoterapi planlamasında, BT ve MRG görüntü eşleştirilmesinin hedef volüm belirlenmesine ve doz dağılımına etkisi. Türk Onkoloji Dergisi. 2011;26(2):67–75. https://doi.org/10.5505/tjoncol.2011.188.

    Article  Google Scholar 

  38. Chrysikopoulos H, Andreou J, Roussakis A, Pappas J. Infarction of the corpus callosum: computed tomography and magnetic resonance imaging. Eur J Radiol. 1997;25:2–8.

    Article  CAS  PubMed  Google Scholar 

  39. Grassi W, Filippucci E. A brief history of ultrasound in rheumatology: where we were. Clin Exp Rheumatol. 2014;32(Suppl.80):S3–6.

    PubMed  Google Scholar 

  40. Liu F, Cao SK, Liu JR, Du ZF, Guo ZM, Ren CJ. Ultrasound measurement of the corpus callosum and neural development of premature infants. Neural Regen Res. 2013;8(26):2432–40. https://doi.org/10.3969/j.issn.1673-5374.2013.26.004.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Ahmadvand A, Shahidi SB, Talari H, Ghoreishi FS, Mousavi GA. Morphology of the corpus callosum and schizophrenia: a case-control study in Kashan, Iran. Electron Physician. 2017;9(10):5478–86.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Allouh MZ, Barbarawi MMA, Ali HA, Mustafa AG, Alomari SO. Morphometric analysis of the corpus callosum according to age and sex in middle eastern arabs: racial comparisons and clinical correlations to autism spectrum disorder. Front Syst Neurosci. 2020;14:30. https://doi.org/10.3389/fnsys.2020.00030.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Poleneni SR, Jakka LD, Chandrupatla M, Vinodini L, Ariyanachi K. Morphometry of corpus callosum in south indian population. Ann Neurosci. 2021;28(3–4):150–5. https://doi.org/10.1177/09727531211059892.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Holloway RL, de Lacoste MC. Sexual dimorphism in the human corpus callosum: an extension and replication study. Hum Neurobiol. 1986;5:87–91.

    CAS  PubMed  Google Scholar 

  45. Junle Y, Youmin G, Yanjun G, Mingyue M, Qiujuan Z, Min X. A MRI quantitative study of corpus callosum in normal adults. J Med Coll PLA. 2008;23(6):346–51. https://doi.org/10.1016/s1000-1948(09)60005-8.

    Article  Google Scholar 

  46. Kosar MI, Erdil FH, Sabanciogullari V, Karacan K, Cimen M, Atalar M. Morphometry of corpus callosum related with gender and age: magnetic resonance imaging study. Pak J Med Sci. 2012;28(3):408–12.

    Google Scholar 

  47. Abdolmaleki A, Mastery Farahani R, Ghoreishi SK, Shaerzadeh F, Aliaghaei A, Mirjavadi SH, Abbaszadeh HA. Magnetic Resonance Imaging-based morphometric assessment of sexual dimorphism of corpus callosum. Anatom Sci. 2016;13(2):117–24.

    Google Scholar 

  48. Choudhury PR, Choudhury P, Baruah P. Morphometric assessment of human corpus callosum on cadaveric brain specimens. J Evol Med Dent Sci. 2020;9(7):388–93. https://doi.org/10.14260/jemds/2020/89.

    Article  Google Scholar 

  49. Pervin S, Nurunnabi ASM, Ara S, Haroon K. Morphometry of the splenium of the corpus callosum – a study on 60 cadaveric brains. Bangladesh J Neurosurg. 2022;11(1):30–5. https://doi.org/10.3329/bjns.v11i1.57990.

    Article  Google Scholar 

  50. Demeter S, Ringo JL, Doty RW. Morphometric analysis of the human corpus callosum and anterior commissure. Hum Neurobiol. 1988;6(4):219–26.

    CAS  PubMed  Google Scholar 

  51. Weber G, Weis S. Morphometric analysis of the human corpus callosum fails to reveal sex- related differences. J Hirnforsch. 1986;27(2):237–40.

    CAS  PubMed  Google Scholar 

  52. De Lacoste-Utamsing C, Holloway RL. Sexual dimorphism in the human corpus callosum. Science. 1982;216:1431–2. https://doi.org/10.1182/blood-2009-06-229658.

    Article  CAS  Google Scholar 

  53. Arda KN, Akay S. The relationship between corpus callosum morphometric measurements and age/gender characteristics: a comprehensive MR imaging study. J Clin Imaging Sci. 2019;9:33. https://doi.org/10.25259/JCIS-13-2019.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Ardekani BA, Figarsky K, Sidtis JJ. Sexual dimorphism in the human corpus callosum: an MRI study using the OASIS brain database. Cereb Cortex. 2013;23(10):2514–20. https://doi.org/10.1093/cercor/bhs253.

    Article  PubMed  Google Scholar 

  55. Downhill JE, Buchsbaum MS, Wei T, Spiegel-Cohen J, Hazlett EA, Haznedar MM, Silverman J, Siever LJ. Shape and size of the corpus callosum in schizophrenia and schizotypal personality disorder. Schizophr Res. 2000;42(3):193–208.

    Article  PubMed  Google Scholar 

  56. Brambilla P, Nicoletti MA, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC. Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder. Biol Psychiatry. 2003;54(11):1294–7.

    Article  PubMed  Google Scholar 

  57. Ballmaier M, Kumar A, Elderkin-Thompson V, Narr KL, Luders E, Thompson PM, Hojatkashani C, Pham D, Heinz A, Toga AW. Mapping callosal morphology in early- and late-onset elderly depression: an index of distinct changes in cortical connectivity. Neuropsychopharmacology. 2008;33(7):1528–36. https://doi.org/10.1038/sj.npp.1301538.

    Article  PubMed  Google Scholar 

  58. Di Paola M, Luders E, Rubino IA, Siracusano A, Manfredi G, Girardi P, Martinotti G, Thompson PM, Chou Y-Y, Toga AW, Caltagirone C, Spalletta G. The structure of the corpus callosum in obsessive compulsive disorder. Eur Psychiatry. 2013;28(8):499–506. https://doi.org/10.1016/j.eurpsy.2012.07.001.

    Article  PubMed  Google Scholar 

  59. Piras F, Vecchio D, Kurth F, Piras F, Banaj N, Ciullo V, Luders E, Spalletta G. Corpus callosum morphology in major mental disorders: a magnetic resonance imaging study. Brain Commun. 2021;3(2):fcab100. https://doi.org/10.1093/braincomms/fcab100.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Hynd GW, Hall J, Novey ES, Eliopulos D, Black K, Gonzalez JJ, Edmonds JE, Riccio C, Cohen M. Dyslexia and corpus callosum morphology. Arch Neurol. 1995;52:32–8.

    Article  CAS  PubMed  Google Scholar 

  61. Wang PP, Doherty S, Hesselink JR, Bellugi U. Callosal morphology concurs with neurobehavioral and neuropathological findings in two neurodevelopmental disorders. Arch Neurol. 1992;49:407–11.

    Article  CAS  PubMed  Google Scholar 

  62. Yamauchi H, Fukuyama H, Nagahama Y, Katsumi Y, Hayashi T, Oyanagi C, Konishi J, Shio H. Comparison of the pattern of atrophy of the corpus callosum in frontotemporal dementia, progressive supranuclear palsy, and Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2000;69:623–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acer, N., Gürlek Çelik, N. (2023). Morphometry of the Corpus Callosum. In: Turgut, M., Tubbs, R.S., Turgut, A.T., Bui, C.C. (eds) The Corpus Callosum. Springer, Cham. https://doi.org/10.1007/978-3-031-38114-0_5

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