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Pathways in Human Arrhythmias: Impact of Post-translational Modifications

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Heart Rate and Rhythm

Abstract

The cardiac proteome has a vast number of gene products that are post-translationally modified (PTM). PTMs are essential for the regulation of normal excitation–contraction coupling. However, dysfunction in PTM may also result in aberrant cardiac excitability and potentially arrhythmia. In this chapter, we review post-translational modifications in the context of normal heart excitation–contraction coupling and in disease.

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Acknowledgments

This work was supported by National Institutes of Health grants HL135754, HL134824, HL139348 and American Heart Association grant 20YVNR35490079.

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Authors and Affiliations

  1. The Frick Center for Heart Failure and Arrhythmia; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Aaron D. Argall & Sara N. Koenig

  2. Dorothy M. Davis Heart and Lung Research Institute; Department of Physiology & Cell Biology; Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA

    Peter J. Mohler

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  1. Aaron D. Argall
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  2. Sara N. Koenig
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  3. Peter J. Mohler
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Correspondence to Peter J. Mohler .

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Editors and Affiliations

  1. Cardiac Electrophysiology Division, Ion Channel Study Center, Life Science Academy, Lucknow, India

    Onkar N. Tripathi

  2. Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada

    T. Alexander Quinn

  3. Institute for Experimental Cardiovascular Medicine, University Heart Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Ursula Ravens

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Argall, A.D., Koenig, S.N., Mohler, P.J. (2023). Pathways in Human Arrhythmias: Impact of Post-translational Modifications. In: Tripathi, O.N., Quinn, T.A., Ravens, U. (eds) Heart Rate and Rhythm. Springer, Cham. https://doi.org/10.1007/978-3-031-33588-4_23

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