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MicroRNAs and Alcohol-Related Liver Disease

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Alcohol and Alcohol-related Diseases

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Abstract

MicroRNAs (miR) are small non-coding RNAs that bind to specific mRNA targets and promote their degradation or inhibit translation. In this book chapter, we reviewed the roles of multiple miRNAs, which are involved in the pathogenesis of alcohol-related liver disease (ALD). We also briefly discuss the roles of miRNAs as the mediators for inter-organ crosstalk and the development of ALD. We provided clues for the potential clinical applications of miRNAs as the prognostic markers and the future perspectives on the use of miRNA-based strategy for the treatment of patients with ALD.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Kristina Perez, Jing Ma, Nazmul Huda, Zhihong Yang & Suthat Liangpunsakul

  2. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA

    Suthat Liangpunsakul

Authors
  1. Kristina Perez
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  2. Jing Ma
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  3. Nazmul Huda
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  4. Zhihong Yang
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  5. Suthat Liangpunsakul
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Correspondence to Suthat Liangpunsakul .

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Editors and Affiliations

  1. Center for Alcohol Resarch, University of Heidelberg, Heidelberg, Germany

    Sebastian Mueller

  2. Linköping University, Affective Neuroscience, Linköping, Sweden

    Markus Heilig

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Perez, K., Ma, J., Huda, N., Yang, Z., Liangpunsakul, S. (2023). MicroRNAs and Alcohol-Related Liver Disease. In: Mueller, S., Heilig, M. (eds) Alcohol and Alcohol-related Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-32483-3_60

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