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Transcriptomics of the Carotid Body

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Arterial Chemoreceptors (ISAC XXI 2022)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1427))

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Abstract

The carotid body (CB) has emerged as a potential therapeutic target for treating sympathetically mediated cardiovascular, respiratory, and metabolic diseases. In adjunct to its classical role as an arterial O2 sensor, the CB is a multimodal sensor activated by a range of stimuli in the circulation. However, consensus on how CB multimodality is achieved is lacking; even the best studied O2-sensing appears to involve multiple convergent mechanisms. A strategy to understand multimodal sensing is to adopt a hypothesis-free, high-throughput transcriptomic approach. This has proven instrumental for understanding fundamental mechanisms of CB response to hypoxia and other stimulants, its developmental niche, cellular heterogeneity, laterality, and pathophysiological remodeling in disease states. Herein, we review this published work that reveals novel molecular mechanisms underpinning multimodal sensing and reveals numerous gaps in knowledge that require experimental testing.

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Notes

  1. 1.

    Study claims to compare the transcriptomes of O2-sensitive organs (CB, AM) to those insensitive to O2 (SCG) (Gao et al. 2017). However, more recently, it was shown that SCG neurons modulate ventilatory responses to hypoxia independently of preganglionic input in mice with bilateral transection of the cervical sympathetic chain (Getsy et al. 2021). This shows that SCG cannot be regarded as O2-insensitive.

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Authors and Affiliations

  1. Manaaki Manawa – The Centre for Heart Research, Department of Physiology, Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand

    Audrys G. Pauza & Julian F. R. Paton

  2. Molecular Neuroendocrinology Research Group, Bristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UK

    David Murphy

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  1. Audrys G. Pauza
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  2. David Murphy
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  3. Julian F. R. Paton
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Correspondence to Audrys G. Pauza .

Editor information

Editors and Affiliations

  1. iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal

    Sílvia V. Conde

  2. Departamento de Fisiología, Universidad Catolica de Chile, Santiago, Chile

    Rodrigo Iturriaga

  3. Departamento de Fisiología, Pontificia Universidad Católica de Chile, Santiago, Chile

    Rodrigo del Rio

  4. Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada

    Estelle Gauda

  5. NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal

    Emília C. Monteiro

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Pauza, A.G., Murphy, D., Paton, J.F.R. (2023). Transcriptomics of the Carotid Body. In: Conde, S.V., Iturriaga, R., del Rio, R., Gauda, E., Monteiro, E.C. (eds) Arterial Chemoreceptors. ISAC XXI 2022. Advances in Experimental Medicine and Biology, vol 1427. Springer, Cham. https://doi.org/10.1007/978-3-031-32371-3_1

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