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Inter-α-inhibitor Proteins: A Review of Structure and Function

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Hyaluronan

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 14))

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Abstract

Inter-α-inhibitor-family proteins (IAIP) are a multifaceted group of complex molecules with important roles in mammalian biology. In the past 20 years, new research has highlighted the central role of this protein family in homeostasis and disease pathogenesis. These insights suggest that IAIP may have significant utility as treatment targets in human disease, and therefore, research into IAIP should be intensified. This review summarizes the current knowledge on IAIP and highlights the remaining gaps in knowledge.

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Acknowledgments

Supported by funds from the Division of Intramural Research, National Institute of Environmental Health Sciences (ES102605).

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  1. Division of Intramural Research, National Institute of Environmental Health Sciences Research Triangle, Durham, NC, USA

    Stavros Garantziotis

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Correspondence to Stavros Garantziotis .

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  1. Department of Medicine and Surgery, University of Insubria, Varese, Italy

    Alberto Passi

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Garantziotis, S. (2023). Inter-α-inhibitor Proteins: A Review of Structure and Function. In: Passi, A. (eds) Hyaluronan. Biology of Extracellular Matrix, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-031-30300-5_6

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