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Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity

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Visceral Pain

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Abstract

Inflammation of the colon is well-established as an initiating factor in the development of chronic visceral pain. Colitis induces sensitisation at peripheral and central sites of the sensory afferent pathways that relay nociceptive signals into the brain. Sensitisation within the spinal cord is an important mechanism maintaining chronic visceral pain beyond colitis resolution and facilitates the development of cross-organ sensitization. This minireview summarises what is currently known from animal acute and post-colitis models on spinal sensitisation and the plasticity involved. These mechanisms have relevance to human inflammatory and functional bowel disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). These prevalent conditions afflict millions of people globally and yet adequate treatments for the chronic visceral pain associated with these disorders are lacking.

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Abbreviations

CRD:

Colorectal distension

CVH:

Chronic visceral hypersensitivity

DCA:

Deoxycholic acid

DH:

Dorsal horn

DNBS:

Dinitrobenzene sulfonic acid

DRG:

Dorsal root ganglia

DSS:

Dextran sulphate sodium

L:

Laminae

LS:

Lumbosacral

TL:

Thoracolumbar

TNBS:

2,4,6-Trinitrobenzene sulfonic acid

VMR:

Visceromotor response

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Acknowledgements

This work was supported by an Australian Research Council (ARC) Discovery Project (DP180101395 and DP220101269 to A.M.H).

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Authors and Affiliations

  1. Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia

    Andrea M. Harrington

  2. Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia

    Andrea M. Harrington

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Correspondence to Andrea M. Harrington .

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Editors and Affiliations

  1. Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia

    Stuart M. Brierley

  2. Visceral Neurophysiology Laboratory, College of Medicine and Public Health & Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia

    Nick J. Spencer

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Harrington, A.M. (2023). Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity. In: Brierley, S.M., Spencer, N.J. (eds) Visceral Pain. Springer, Cham. https://doi.org/10.1007/978-3-031-25702-5_14

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