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Neurodevelopmental Disorders of the Cerebellum: Autism Spectrum Disorder

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Development of the Cerebellum from Molecular Aspects to Diseases

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with an incidence of 1 in 68 children. Cerebellar abnormalities have been observed in many ASD patients. The cerebellum is an elaborate brain region crucially important for motor learning and coordination of movement, and increasing lines of evidence indicate that the cerebellum also contributes to emotion and cognition. In this chapter, we will review the genetic and environmental factors that may contribute to cerebellar deficits in ASD patients. Structural and functional cerebellar abnormalities based on neuroimaging and histopathological studies and current approaches to management will be discussed.

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Acknowledgments

The authors’ research is supported by grants from the Natural Sciences and Engineering Research Council (HM: NSERC Discovery Grant # RGPIN-2018-06040), the Children’s Hospital Research Institute of Manitoba (HM: CHRIM Grant # 320035), and Research Manitoba Tri-Council Bridge Funding Program (HM: Grant # 47955).

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Authors and Affiliations

  1. Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, Canada

    Mehnosh Toback, Azam Asemi Rad, Mohammad Allahtavakoli & Hassan Marzban

  2. Anatomy Department, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria

    Izuchukwu Azuka Okafor

  3. Sina Laboratory Building, Arak, Iran

    Kambiz Zangeneh

  4. Department of Physiology and Pathophysiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Tabrez J. Siddiqui

  5. Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre, Winnipeg, MB, Canada

    Tabrez J. Siddiqui

  6. Department of Human Anatomy and Cell Science, The Children’s Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Science, University of Manitoba, Winnipeg, MB, Canada

    Hassan Marzban

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    Hassan Marzban

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Toback, M. et al. (2023). Neurodevelopmental Disorders of the Cerebellum: Autism Spectrum Disorder. In: Marzban, H. (eds) Development of the Cerebellum from Molecular Aspects to Diseases. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-23104-9_21

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