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Benign Tumors of the Lungs

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Airway diseases

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Abstract

In 2015, benign lung tumors were defined by the World Health Organization (WHO) as extremely rare tumors originating from three different cell types, namely epithelial, mesenchymal, and ectopic [1] (Table 1).

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References

  1. Travis WD, Brambilla E, Burke AP, et al. Introduction to the 2015 World Health Organization classification of tumors of the lung, pleura, thymus, and heart. J Thorac Oncol. 2015;10(9):1240–2.

    Article  PubMed  Google Scholar 

  2. Robinson PG, Shields TW. Benign tumors of the lung. In: Shields TW, Locicero J, Reed CE, Feins RH, editors. General thoracic surgery, vol. 2. 7th ed. Philadelphia: Lippincott Williams and Wilkins; 2009.

    Google Scholar 

  3. Martini N. Results of the memorial Sloan-Kettering lung project. In: Early detection and localization of lung tumors in high risk groups. Berlin, Heidelberg: Springer; 1982. p. 174–8.

    Chapter  Google Scholar 

  4. Jones RC, Cleve EA. Solitary circumscribed lesions of the lung. Arch Intern Med. 1954;93(6):842–9.

    Article  CAS  Google Scholar 

  5. Yüksel M, Akgül A. Akciğerin iyi huylu tümörleri. In: Yüksel M, Kalaycı NG, editors. Göğüs cerrahisi. İstanbul: Bilmedya Grup; 2001.

    Google Scholar 

  6. Thomas JW, Staerkel GA, Whitman GJ. Pulmonary hamartoma. AJR Am J Roentgenol. 1999;172(6):1643.

    Article  CAS  PubMed  Google Scholar 

  7. Arrigoni MG, Woolner LB, Bernatz PE, et al. Benign tumors of the lung: a ten-year surgical experience. J Thorac Cardiovasc Surg. 1970;60(4):589–99.

    Article  CAS  PubMed  Google Scholar 

  8. McDonald JR, Harrinhgton SW, Clagett OT, et al. Solitary circumscribed lesions of the lung. Arch Intern Med. 1954;93:842.

    Article  Google Scholar 

  9. Dahnert W. Radiology review manual. 3rd ed. Baltimore: Williams & Wilkins; 1996. p. 364.

    Google Scholar 

  10. Bateson EM. So-called hamartoma of the lung-a true neoplasm of fibrous connective tissue of the bronchi. Cancer. 1973;31(6):1458–67.

    Article  CAS  PubMed  Google Scholar 

  11. Kazmierczak B, Rosigkeit J, Wanschura S, et al. HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene. 1996;12(3):515.

    CAS  PubMed  Google Scholar 

  12. Siegelman SS, Khouri NF, Scott W Jr, et al. Pulmonary hamartoma: CT findings. Radiology. 1986;160(2):313–7.

    Article  CAS  PubMed  Google Scholar 

  13. Oldham HN Jr, Young WG Jr, Sealy WC. Hamartoma of the lung. J Thorac Cardiovasc Surg. 1967;53:735–42.

    Article  PubMed  Google Scholar 

  14. Ledor K, Fish B, Chaise L, et al. CT diagnosis of pulmonary hamartomas. J Comput Assist Tomogr. 1981;5:343–4.

    Article  CAS  Google Scholar 

  15. Hansen CP, Holtveg H, Francis D, et al. Pulmonary hamartoma. J Thorac Cardiovasc Surg. 1992;104(3):674–8.

    Article  CAS  PubMed  Google Scholar 

  16. Hamper UM, Khouri NF, Stitik FP, et al. Pulmonary hamartoma: diagnosis by transthoracic needle-aspiration biopsy. Radiology. 1985;155(1):15–8.

    Article  CAS  PubMed  Google Scholar 

  17. Carney JA. Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metabol. 2009;94(10):3656–62.

    Article  CAS  Google Scholar 

  18. Bini A, Grazia M, Petrella F, et al. Multiple chondromatous hamartomas of the lung. Interact Cardiovasc Thorac Surg. 2002;1(2):78–80.

    Article  CAS  PubMed  Google Scholar 

  19. Gebauer C. Hamartochondroma der Lungen und Bronchien. Prax Klin Pneumo I. 1980;34:641–50.

    CAS  Google Scholar 

  20. Karasik A, Modan M, Jacob CO, et al. Increased risk of lung cancer in patients with chondromatous hamartoma. J Thorac Cardiovasc Surg. 1980;80(2):217–20.

    Article  CAS  PubMed  Google Scholar 

  21. Nili M, Vidne BA, Avidor I, et al. Multiple pulmonary hamartomas; a case report and review of the literature. Scand J Thorac Cardiovasc Surg. 1979;13(2):157–60.

    Article  CAS  PubMed  Google Scholar 

  22. Hoekstra MO, Bertus PM, Nikkels PG, et al. Multiple pulmonary chondromata: a rare cause of neonatal respiratory distress. Chest. 1994;105(1):301–2.

    Article  CAS  PubMed  Google Scholar 

  23. Tian D, Wen H, Zhou Y, et al. Pulmonary chondroma: a clinicopathological study of 29 cases and a review of the literature. Mol Clin Oncol. 2016;5(3):211–5.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Shi G, Cui Y, He Y, et al. An unusual case of incomplete Carney triad: an 18-year-old girl suffering from multiple benign tumors. J Thorac Dis. 2016;8(10):E1202.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Carney JA, Sheps SG, Go VL, et al. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl J Med. 1977;296(26):1517–8.

    Article  CAS  PubMed  Google Scholar 

  26. Spatz A, Paillerets BBD, Raymond E. Soft tissue sarcomas: CASE 3. Gastrointestinal stromal tumor and Carney’s triad. J Clin Oncol. 2004;22(10):2029–31.

    Article  PubMed  Google Scholar 

  27. Qiao GB, Zeng WS, Peng LJ, et al. Multiple pulmonary chondromas in a young female patient: a component of Carney triad. J Thorac Oncol. 2009;4(6):751–2.

    Article  PubMed  Google Scholar 

  28. Vega J, Navarro SJ, Lovera RC, et al. Carney triad: report of one case. Rev Med Chil. 2017;145(4):533.

    Article  PubMed  Google Scholar 

  29. Hornick JL, Fletcher CDM. PEComa: what do we know so far? Histopathology. 2006;48(1):75–82.

    Article  CAS  PubMed  Google Scholar 

  30. Travis WD, Colby T, Corrin B, et al. In collaboration with LHS, Countries pf. Histological typing of lung and pleural tumors. Berlin: Springer; 1999.

    Book  Google Scholar 

  31. Travis WD, Brambilla E, Müller-Hermelink HK, et al. Pathology and genetics: tumours of the lung, pleura, thymus and heart. Lyon: IARC; 2004.

    Google Scholar 

  32. Taylor JR, Ryu J, Colby TV, et al. Lymphangioleiomyomatosis. N Engl J Med. 1990;323:1254–60.

    Article  CAS  PubMed  Google Scholar 

  33. Carrington CB, Cugell DW, Gaensler EA, et al. Lymphangioleiomyomatosis. Physiologic-pathologic-radiologic correlations. Am Rev Respir Dis. 1977;116(6):977–95.

    CAS  PubMed  Google Scholar 

  34. Yamazaki A, Miyamoto H, Futagawa T, et al. An early case of pulmonary lymphangioleiomyomatosis diagnosed by video-assisted thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2005;11:405–7.

    PubMed  Google Scholar 

  35. Ryu JH, Moss J, Beck GJ, et al. The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment. Am J Respir Crit Care Med. 2006;173:105–11.

    Article  PubMed  Google Scholar 

  36. Park HY, Nam HS, Chung MP, et al. A nationwide survey of lymphangioleiomyomatosis in Korea: recent increase in newly diagnosed patients. J Korean Med Sci. 2010;25(8):1182–6.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Johnson SR, Cordier JF, Lazor R, et al. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J. 2010;35(1):14–26.

    Article  CAS  PubMed  Google Scholar 

  38. Hohman DW, Noghrehkar D, Ratnayake S. Lymphangioleiomyomatosis: a review. Eur J Intern Med. 2008;19(5):319–24.

    Article  PubMed  Google Scholar 

  39. Çağırıcı U. Akciğerin benign ve ender görülen malign tümörleri. In: Ökten İ, Güngör A, editors. Göğüs Cerrahisi. Ankara: Sim Matbaacılık; 2003. p. 1039–52.

    Google Scholar 

  40. Zeybek AA, Demircan A. Akciğerin benign tümörleri. In: Ökten İ, Kavukçu HŞ, editors. Göğüs Cerrahisi. İstanbul: İstanbul Medikal Sağlık ve Yayıncılık; 2013.

    Google Scholar 

  41. Logginidou H, Ao X, Russo I, et al. Frequent estrogen and progesterone receptor immunoreactivity in renal angiomyolipomas from women with pulmonary lymphangioleiomyomatosis. Chest. 2000;117(1):25–30.

    Article  CAS  PubMed  Google Scholar 

  42. Brunelli A, Catalini G, Fianchini A. Pregnancy exacerbating unsuspected mediastinal lymphangioleiomyomatosis and chylothorax. Int J Gynaecol Obstet. 1996;52(3):289–90.

    Article  CAS  PubMed  Google Scholar 

  43. Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci. 2000;97(11):6085–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. McCormack FX, Travis WD, Colby T, et al. Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm. Am J Respir Crit Care Med. 2012;186(12):1210–2.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Johnson SR, Whale CI, Hubbard RB, et al. Survival and disease progression in UK patients with lymphangioleiomyomatosis. Thorax. 2004;59(9):800–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. McCormack FX. Lymphangioleiomyomatosis: a clinical update. Chest. 2008;133(2):507–16.

    Article  CAS  PubMed  Google Scholar 

  47. Taveira-DaSilva AM, Burstein D, Hathaway OM, et al. Pneumothorax after air travel in lymphangioleiomyomatosis, idiopathic pulmonary fibrosis, and sarcoidosis. Chest. 2009;136(3):665–70.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Taveira-DaSilva AM, Steagall WK, Moss J. Lymphangioleiomyomatosis. Cancer Control. 2006;13:276–85.

    Article  PubMed  Google Scholar 

  49. Dail DH, Hammar SP, Colby TV. Uncommon tumors. In: Pulmonary pathology – tumors. New York: Springer Science & Business Media; 2012. p. 219–24.

    Google Scholar 

  50. Sen S, Senturk E, Kuman NK, et al. PEComa (clear cell “sugar” tumor) of the lung: a benign tumor that presented with thrombocytosis. Ann Thorac Surg. 2009;88(6):2013–5.

    Article  PubMed  Google Scholar 

  51. Yazak V, Sargin G, Yavasoglu I, et al. Lung clear “sugar” cell tumor and JAK V617F positive essential thrombocythemia: a simple coincidence? Mediterr J Hematol Infect Dis. 2013;5(1):e2013021.

    Article  PubMed  PubMed Central  Google Scholar 

  52. McGinnis M, Jacobs G, El-Naggar AK, et al. Congenital peribronchial myofibroblastic tumor (so-called “congenital leiomyosarcoma”). A distinct neonatal lung lesion associated with nonimmune hydrops fetalis. Mod Pathol. 1993;6(4):487–92.

    CAS  PubMed  Google Scholar 

  53. Luisi F, Torre O, Harari S. Thoracic involvement in generalised lymphatic anomaly (or lymphangiomatosis). Eur Respir Rev. 2016;25(140):170–7.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Ming-hua DU, Ruan-jian YE, Kun-kun SUN, et al. Diffuse pulmonary lymphangiomatosis: a case report with literature review. Chin Med J. 2011;124(5):797–800.

    Google Scholar 

  55. El Hajj L, Mazieres J, Rouquette I, et al. Diagnostic value of bronchoscopy, CT and transbronchial biopsies in diffuse pulmonary lymphangiomatosis: case report and review of the literature. Clin Radiol. 2005;60(8):921–5.

    Article  PubMed  Google Scholar 

  56. Yu W, Mi L, Cong J, et al. Diffuse pulmonary lymphangiomatosis: a rare case report in an adult. Medicine. 2019;98(43):e17349.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Lee AW, Rajanayagam J, Sarikwal A, et al. Hepatobiliary and pancreatic: liver transplantation for massive hepatic lymphangiomatosis. J Gastroenterol Hepatol. 2014;29(2):233.

    Article  PubMed  Google Scholar 

  58. Rostom AY. Treatment of thoracic lymphangiomatosis. Arch Dis Child. 2000;83(2):138–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Zhou H, Zhong C, Fu Q, et al. Thoracoscopic resection of a huge mediastinal cystic lymphangioma. J Thorac Dis. 2017;9(10):E887.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Amodeo I, Colnaghi M, Raffaeli G, et al. The use of sirolimus in the treatment of giant cystic lymphangioma: four case reports and update of medical therapy. Medicine. 2017;96(51):e8871.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Laforgia N, Schettini F, De Mattia D, et al. Lymphatic malformation in newborns as the first sign of diffuse lymphangiomatosis: successful treatment with sirolimus. Neonatology. 2016;109(1):52–5.

    Article  CAS  PubMed  Google Scholar 

  62. Nammour S, Vanheusden A, Namour A, et al. Evaluation of a new method for the treatment of invasive, diffuse, and unexcisable lymphangiomas of the oral cavity with defocus CO2 laser beam: a 20-year follow-up. Photomed Laser Surg. 2016;34(2):82–7.

    Article  PubMed  Google Scholar 

  63. Alexiou C, Obuszko Z, Beggs D. Inflammatory pseudotumors of the lung. Ann Thorac Surg. 1998;66:948–50.

    Article  CAS  PubMed  Google Scholar 

  64. Karnak I, Senocak ME, Ciftci AO, et al. Inflammatory myofibroblastic tumor in children: diagnosis and treatment. J Pediatr Surg. 2001;36(6):908–12.

    Article  CAS  PubMed  Google Scholar 

  65. Umiker WO. Post-inflammatory “tumors” of the lung. Report of four cases simulating xanthoma, fibroma or plasma cell tumor. J Thorac Surg. 1954;28:55–63.

    Article  CAS  PubMed  Google Scholar 

  66. Döngel I, Yazkan R, Duman L, et al. Huge inflammatory myofibroblastic tumor of pleura with concomitant nuchal fibroma. Ann Thorac Surg. 2013;96(4):1461–4.

    Article  PubMed  Google Scholar 

  67. Narla LD, Newman B, Spottswood SS, et al. Inflammatory pseudotumor. Radiographics. 2003;23(3):719–29.

    Article  PubMed  Google Scholar 

  68. Hedlund GL, Navoy JF, Galliani CA, et al. Aggressive manifestations of inflammatory pulmonary pseudotumor in children. Pediatr Radiol. 1999;29:112–6.

    Article  CAS  PubMed  Google Scholar 

  69. Coffin CM. Inflammatory myofibroblastic tumour: World Health Organization classification of tumours. In: Fletcher CDM, Mertens F, editors. World Health Organization classification of tumours pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002.

    Google Scholar 

  70. Ono A, Murakami H, Serizawa M, et al. Drastic initial response and subsequent response to two ALK inhibitors in a patient with a highly aggressive ALK-rearranged inflammatory myofibroblastic tumor arising in the pleural cavity. Lung Cancer. 2016;99:151–4.

    Article  PubMed  Google Scholar 

  71. Griffin CA, Hawkins AL, Dvorak C, et al. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res. 1999;59(12):2776–80.

    CAS  PubMed  Google Scholar 

  72. Chan JK, Cheuk W, Shimizu M. Anaplastic lymphoma kinase expression in inflammatory pseudotumors. Am J Surg Pathol. 2001;25(6):761–8.

    Article  CAS  PubMed  Google Scholar 

  73. Kovach SJ, Fischer AC, Katzman PJ, et al. Inflammatory myofibroblastic tumors. J Surg Oncol. 2006;94(5):385–91.

    Article  PubMed  Google Scholar 

  74. Shanmuganathan A, Dhungel K, Mahale A, et al. Inflammatory myofibroblastic tumor of lung (pseudotumor of the lung). Indian J Radiol Imaging. 2006;16(2):207–10.

    Article  Google Scholar 

  75. Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol. 1991;15(12):1146–56.

    Article  CAS  PubMed  Google Scholar 

  76. Melloni G, Carretta A, Ciriaco P, et al. Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg. 2005;79(2):426–32.

    Article  PubMed  Google Scholar 

  77. Mehta J, Desphande S, Stauffer JL, et al. Plasma cell granuloma of the lung: endobronchial presentation and absence of response to radiation therapy. South Med J. 1980;73(9):1198–201.

    Article  CAS  PubMed  Google Scholar 

  78. Mandelbaum I, Brashear RE, Hull MT. Surgical treatment and course of pulmonary pseudotumor (plasma cell granuloma). J Thorac Cardiovasc Surg. 1981;82(1):77–82.

    Article  CAS  PubMed  Google Scholar 

  79. Sanchez PG, Madke GR, Pilla ES, et al. Endobronchial inflammatory pseudotumor: a case report. J Bras Pneumol. 2007;33(4):484–6.

    Article  PubMed  Google Scholar 

  80. Çobanoğlu U, Kırgın HÖ, Uğurluer G. Akciğerin İnflamatuar Psödotümörü: Olgu Sunumu. Van Tıp Dergisi. 2008;15(3):95–8.

    Google Scholar 

  81. Higashiyama M, Kodama K, Yokouchi H, et al. Myoepithelioma of the lung: report of two cases and review of the literature. Lung Cancer. 1998;20(1):47–56.

    Article  CAS  PubMed  Google Scholar 

  82. Morinaga S, Nakajima T, Shimosato Y. Normal and neoplastic myoepithelial cells in salivary glands: an immunohistochemical study. Hum Pathol. 1987;18(12):1218–26.

    Article  CAS  PubMed  Google Scholar 

  83. Rosai J. Major and minor salivary glands. In: Stamathi G, editor. Ackerman’s surgical pathology. 7th ed. St. Louis: Mosby; 1989. p. 655–7.

    Google Scholar 

  84. Luna MA, Batsakis JG, Ordonez NG, et al. Salivary gland adenocarcinomas: a clinicopathologic analysis of three distinctive types. Semin Diagn Pathol. 1987;4(2):117–35.

    CAS  PubMed  Google Scholar 

  85. Erkiliç S, Koçer NE, Tuncozgur B. Peripheral intrapulmonary lipoma: a case report. Acta Chir Belg. 2007;107(6):700–2.

    Article  PubMed  Google Scholar 

  86. Wood J, Henderson RG. Peripheral intrapulmonary lipoma: a rare lung neoplasm. Br J Radiol. 2004;77(913):60–2.

    Article  CAS  PubMed  Google Scholar 

  87. Döngel I, Duman L, Camas HE. Hypertrophic epicardial adipose tissue mimicking a thoracic mass. Asian Cardiovasc Thorac Ann. 2017;25(5):406.

    Article  PubMed  Google Scholar 

  88. Kim NR, Kim HJ, Kim JK, et al. Intrapulmonary lipomas: report of four cases. Histopathology. 2003;42(3):305–6.

    Article  CAS  PubMed  Google Scholar 

  89. Sugio K, Yokoyama H, Kaneko S, et al. Sclerosing hemangioma of the lung: radiographic and pathological study. Ann Thorac Surg. 1992;53(2):295–300.

    Article  CAS  PubMed  Google Scholar 

  90. Muraoka M, Oka T, Akamine S, et al. Endobronchial lipoma: review of 64 cases reported in Japan. Chest. 2003;123(1):293–6.

    Article  PubMed  Google Scholar 

  91. Sugarbaker DJ. Benign lung masses. In: Platis IE, Bogner PN, Nwogu CE, editors. Adult chest surgery. New York: The McGraw-Hill Companies; 2009. p. 666–709.

    Google Scholar 

  92. Kuruvilla S, Saldanha R, Joseph LD. Recurrent respiratory papillomatosis complicated by aspergillosis: a case report with review of literature. J Postgrad Med. 2008;54(1):32.

    Article  CAS  PubMed  Google Scholar 

  93. Oldham JH. Benign tumors of the lung and bronchus. Surg Clin North Am. 1980;60(4):825–34.

    Article  PubMed  Google Scholar 

  94. Böhm J, Fellbaum C, Bautz W, et al. Pulmonary nodule caused by an alveolar adenoma of the lung. Virchows Arch. 1997;430(2):181–4.

    Article  PubMed  Google Scholar 

  95. Ishida T, Kamachi M, Hanada T, et al. Mucous gland adenoma of the trachea resected with an endoscopic neodymium: yttrium aluminum garnet laser. Intern Med. 1996;35(11):890–3.

    Article  CAS  PubMed  Google Scholar 

  96. Popper HH, El-Shabrawi Y, Wöckel W, et al. Prognostic importance of human papilloma virus typing in squamous cell papilloma of the bronchus: comparison of in situ hybridization and the polymerase chain reaction. Hum Pathol. 1994;25(11):1191–7.

    Article  CAS  PubMed  Google Scholar 

  97. Miura H, Tsuchida T, Kawate N, et al. Asymptomatic solitary papilloma of the bronchus: review of occurrence in Japan. Eur Respir J. 1993;6(7):1070–3.

    Article  CAS  PubMed  Google Scholar 

  98. Flieder DB, Koss MN, Nicholson A, et al. Solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature. Am J Surg Pathol. 1998;22(11):1328–42.

    Article  CAS  PubMed  Google Scholar 

  99. Tryfon S, Dramba V, Zoglopitis F, et al. Solitary papillomas of the lower airways: epidemiological, clinical, and therapeutic data during a 22-year period and review of the literature. J Thorac Oncol. 2012;7(4):643–8.

    Article  PubMed  Google Scholar 

  100. Katzenstein AL, Gmelich JT, Carrington CB. Sclerosing hemangioma of the lung: a clinicopathologic study of 51 cases. Am J Surg Pathol. 1980;4(4):343–56.

    Article  CAS  PubMed  Google Scholar 

  101. Iyoda A, Hiroshima K, Shiba M, et al. Clinicopathological analysis of pulmonary sclerosing hemangioma. Ann Thorac Surg. 2004;78(6):1928–31.

    Article  PubMed  Google Scholar 

  102. Devouassoux-Shisheboran M, Hayashi T, Linnoila RI, et al. A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. Am J Surg Pathol. 2000;24(7):906–16.

    Article  CAS  PubMed  Google Scholar 

  103. Chan AC, Chan JK. Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): a new clue to its histogenesis. Am J Surg Pathol. 2000;24(11):1531–6.

    Article  CAS  PubMed  Google Scholar 

  104. Liebow AA, Hubbell DS. Sclerosing hemangioma (histiocytoma, xanthoma) of the lung. Cancer. 1956;9(1):53–75.

    Article  CAS  PubMed  Google Scholar 

  105. Niho S, Suzuki K, Yokose T, et al. Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. Am J Pathol. 1998;152(4):1065.

    CAS  PubMed  PubMed Central  Google Scholar 

  106. Kavas M, Öztürk A, Derdiyok O, et al. Rare lung tumors: alveolar adenoma-four case reports. Turkish Thorac J. 2019;20(3):203.

    Article  Google Scholar 

  107. Oliveira P, Almeida MO, Nunes JM, et al. Alveolar adenoma of the lung: further characterization of this uncommon tumour. Virchows Arch. 1996;429(2–3):101–8.

    CAS  PubMed  Google Scholar 

  108. Wang L, Wang X, Rustam A, et al. Alveolar adenoma resected by thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2013;19(6):489–91.

    Article  PubMed  Google Scholar 

  109. Wang X, Li WQ, Yan HZ, et al. Alveolar adenoma combined with multifocal cysts: case report and literature review. J Int Med Res. 2013;41(3):895–906.

    Article  PubMed  Google Scholar 

  110. Fantone JC, Geisinger KR, Appelman HD. Papillary adenoma of the lung with lamellar and electron dense granules an ultrastructural study. Cancer. 1982;50(12):2839–44.

    Article  CAS  PubMed  Google Scholar 

  111. Spencer H, Dail DH, Arneaud J. Non-invasive bronchial epithelial papillary tumors. Cancer. 1980;45(6):1486–97.

    Article  CAS  PubMed  Google Scholar 

  112. Noguchi M, Kodama T, Shimosato Y, et al. Papillary adenoma of type 2 pneumocytes. Am J Surg Pathol. 1986;10(2):134–9.

    Article  CAS  PubMed  Google Scholar 

  113. Sánchez-Jiménez J, Ballester-Martínez A, Lodo-Besse J, et al. Papillary adenoma of type 2 pneumocytes. Pediatr Pulmonol. 1994;17(6):396–400.

    Article  PubMed  Google Scholar 

  114. Mori M, Chiba R, Tezuka F, et al. Papillary adenoma of type II pneumocytes might have malignant potential. Virchows Arch. 1996;428(3):195–200.

    Article  CAS  PubMed  Google Scholar 

  115. Minami Y, Morishita Y, Yamamoto T, et al. Cytologic characteristics of pulmonary papillary adenoma. A case report. Acta Cytol. 2004;48(2):243–8.

    Article  PubMed  Google Scholar 

  116. Dessy E, Braidotti P, Del Curto B, et al. Peripheral papillary tumor of type-II pneumocytes: a rare neoplasm of undetermined malignant potential. Virchows Arch. 2000;436(3):289–95.

    Article  CAS  PubMed  Google Scholar 

  117. Haruki T, Nakamura H, Taniguchi Y, et al. Pulmonary mucinous cystadenoma: a rare benign tumor of the lung. Gen Thorac Cardiovasc Surg. 2010;58(6):287–90.

    Article  PubMed  Google Scholar 

  118. Couraud S, Isaac S, Guibert B, et al. Bronchial mucous gland adenoma revealed following acute pneumonia. Interact Cardiovasc Thorac Surg. 2012;14(3):347–9.

    Article  PubMed  Google Scholar 

  119. England DM, Hochholzer L. Truly benign “bronchial adenoma”. Report of 10 cases of mucous gland adenoma with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 1995;19(8):887–99.

    Article  CAS  PubMed  Google Scholar 

  120. Domen H, Iwashiro N, Kimura N, et al. Bronchial mucous gland adenoma. J Jpn Soc Respir Endosc. 2019;41(3):268–72.

    Google Scholar 

  121. Drevelegas A, Palladas P, Scordalaki A. Mediastinal germ cell tumors: a radiologic–pathologic review. Eur Radiol. 2001;11(10):1925–32.

    Article  CAS  PubMed  Google Scholar 

  122. Delmo Walter EM, Javier MF, Sander F, et al. Primary cardiac tumors in infants and children: surgical strategy and long-term outcome. Ann Thorac Surg. 2016;102:2062–9.

    Article  PubMed  Google Scholar 

  123. Myers PO, Kritikos N, Bongiovanni M, et al. Primary intrapulmonary thymoma: a systematic review. Eur J Surg Oncol (EJSO). 2007;33(10):1137–41.

    Article  CAS  PubMed  Google Scholar 

  124. Cesario A, Galetta D, Margaritora S, et al. Unsuspected primary pulmonary meningioma. Eur J Cardiothorac Surg. 2002;21(3):553–5.

    Article  PubMed  Google Scholar 

  125. Incarbone M, Ceresoli GL, Di Tommaso L, et al. Primary pulmonary meningioma: report of a case and review of the literature. Lung Cancer. 2008;62(3):401–7.

    Article  PubMed  Google Scholar 

  126. Meirelles GSP, Ravizzini G, Moreira AL, et al. Primary pulmonary meningioma manifesting as a solitary pulmonary nodule with a false-positive PET scan. J Thorac Imaging. 2006;21(3):225–7.

    Article  PubMed  Google Scholar 

  127. Yekeler E, Dursun M, Yilmazbayhan D, et al. Multiple pulmonary metastases from intracranial meningioma: MR imaging findings. Diagn Interv Radiol. 2005;11:28–30.

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Süleyman Demirel University, Medical Faculty, Isparta, Turkey

    Süleyman Emre Akın & İsa Döngel

  2. Department of Cardiovascular and Thoracic Surgery, West Virginia University Medical School, Morgantown, WV, USA

    Alper Toker

Authors
  1. Süleyman Emre Akın
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  2. İsa Döngel
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  3. Alper Toker
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Editor information

Editors and Affiliations

  1. Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskisehir, Türkiye

    Cemal Cingi

  2. Department of Pulmonology, Celal Bayar University, Manisa, Türkiye

    Arzu Yorgancıoğlu

  3. Department of Otorhinolaryngology, Kırıkkale University, Kırıkkale, Türkiye

    Nuray Bayar Muluk

  4. Federal University of Bahia School of Medicine and ProAR Foundation, Salvador - Bahia, Brazil

    Alvaro A. Cruz

Section Editor information

  1. Department of Chest Disease, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    Muzaffer Metintaş MD

  2. Department of Chest Disease, Eskisehir Osmangazi University, Eskisehir, Turkey

    Guntulu Ak

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Akın, S.E., Döngel, İ., Toker, A. (2023). Benign Tumors of the Lungs. In: Cingi, C., Yorgancıoğlu, A., Bayar Muluk, N., Cruz, A.A. (eds) Airway diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-22483-6_82-1

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  • DOI: https://doi.org/10.1007/978-3-031-22483-6_82-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-22482-9

  • Online ISBN: 978-3-031-22483-6

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