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Obstructive Sleep Apnea

A Neurologic Perspective

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Airway diseases

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Abstract

Obstructive sleep apnea syndrome (OSAS) is a highly prevalent, chronic multisystem disease with repetitive occlusions in the upper airway leading to intermittent hypoxia and recurrent hypoxemia [1]. Due to its origin and various systemic effects, a multidisciplinary approach of pulmonology, ENT, and neurology is essential (Figs. 1a–c and 2).

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References

  1. Rosenzweig I, Glasser M, Polsek D, Leschziner GD, Williams SC, Morrell MJ. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med. 2015;3(5):404–14.

    Article  PubMed  Google Scholar 

  2. Pan W, Kastin AJ. Can sleep apnea cause Alzheimer’s disease? Neurosci Biobehav Rev. 2014;47:656–69.

    Article  PubMed  Google Scholar 

  3. Lavie L. Oxidative stress in obstructive sleep apnea and intermittent hypoxia–revisited–the bad ugly and good: implications to the heart and brain. Sleep Med Rev. 2015;20:27–45.

    Article  PubMed  Google Scholar 

  4. Andrade AG, Bubu OM, Varga A, Osorio RS. The relationship between obstructive sleep apnea and Alzheimer’s disease. J Alzheimers Dis. 2018;64(s1):S255–70.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006;23(10):2739–48.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Nair D, Dayyat EA, Zhang SX, Wang Y, Gozal D. Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. PLoS One. 2011;6(5):e19847.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005;172(11):1447–51.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Ancoli-Israel S, Klauber MR, Butters N, Parker L, Kripke DF. Dementia in institutionalized elderly: relation to sleep apnea. J Am Geriatr Soc. 1991;39(3):258–63.

    Article  CAS  PubMed  Google Scholar 

  9. Lavie P, Lavie L, Herer P. All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age. Eur Respir J. 2005;25(3):514–20.

    Article  CAS  PubMed  Google Scholar 

  10. Gooneratne NS, Richards KC, Joffe M, Lam RW, Pack F, Staley B, Pack AI. Sleep-disordered breathing with excessive daytime sleepiness is a risk factor for mortality in older adults. Sleep. 2011;34(4):435–42.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Emamian F, Khazaie H, Tahmasian M, Leschziner GD, Morrell MJ, Hsiung GYR, Sepehry AA. The association between obstructive sleep apnea and Alzheimer’s disease: a meta-analysis perspective. Front Aging Neurosci. 2016;8:78.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mokhlesi B, Finn LA, Hagen EW, Young T, Hla KM, Van Cauter E, Peppard PE. Obstructive sleep apnea during REM sleep and hypertension. Results of the Wisconsin Sleep Cohort. Am J Respir Crit Care Med. 2014;190(10):1158–67.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Varga AW, Kishi A, Mantua J, Lim J, Koushyk V, Leibert DP, Ayappa I. Apnea-induced rapid eye movement sleep disruption impairs human spatial navigational memory. J Neurosci. 2014;34(44):14571–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci. 2010;11(2):114–26.

    Article  CAS  PubMed  Google Scholar 

  15. Lewellyn S, Hobson JA. Not only… but also: REM sleep creates and NREM stage 2 instantiates landmark junctions in cortical memory networks. Neurobiol Learn Mem. 2015;122:69–87.

    Article  Google Scholar 

  16. Boyce R, Glasgow SD, Williams S, Adamantidis A. Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation. Science. 2016;352(6287):812–6.

    Article  CAS  PubMed  Google Scholar 

  17. Haba-Rubio J, Marti-Soler H, Tobback N, Andries D, Marques-Vidal P, Waeber G, Popp J. Sleep characteristics and cognitive impairment in the general population: the HypnoLaus study. Neurology. 2017;88(5):463–9.

    Article  PubMed  Google Scholar 

  18. Marshall L, Helgadóttir H, Mölle M, Born J. Boosting slow oscillations during sleep potentiates memory. Nature. 2006;444(7119):610–3.

    Article  CAS  PubMed  Google Scholar 

  19. Polsek D, Gildeh N, Cash D, Winsky-Sommerer R, Williams SCR, Turkheimer F, Rosenzweig I. Obstructive sleep apnoea and Alzheimer’s disease: in search of shared pathomechanisms. Neurosci Biobehav Rev. 2018;86:142–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Carvalho DZ, Gerhardt GJ, Dellagustin G, Emerson L, Lemke N, Segal AZ, Schönwald SV. Loss of sleep spindle frequency deceleration in obstructive sleep apnea. Clin Neurophysiol. 2014;125(2):306–12.

    Article  PubMed  Google Scholar 

  21. Yaffe K, Falvey CM, Hoan T. Connections between sleep and cognition in older adults. Lancet Neurol. 2014;13(10):1017–28.

    Article  PubMed  Google Scholar 

  22. Ju YES, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP, Holtzman DM. Sleep quality and preclinical Alzheimer disease. JAMA Neurol. 2013;70(5):587–93.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Holtzman DM. Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle. Science. 2009;326(5955):1005–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Phelps CH. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280–92.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Huang Y, Potter R, Sigurdson W, Santacruz A, Shih S, Ju YE, Bateman RJ. Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system. Arch Neurol. 2012;69(1):51–8.

    Article  PubMed  Google Scholar 

  26. Yun CH, Lee HY, Lee SK, Kim H, Seo HS, Bang S, Thomas RJ. Amyloid burden in obstructive sleep apnea. J Alzheimers Dis. 2017;59(1):21–9.

    Article  CAS  PubMed  Google Scholar 

  27. Shiota S, Takekawa H, Matsumoto SE, Takeda K, Nurwidya F, Yoshioka Y, Takahashi K. Chronic intermittent hypoxia/reoxygenation facilitate amyloid-β generation in mice. J Alzheimers Dis. 2013;37(2):325–33.

    Article  CAS  PubMed  Google Scholar 

  28. Liguori C, Mercuri NB, Izzi F, Romigi A, Cordella A, Sancesario G, Placidi F. Obstructive sleep apnea is associated with early but possibly modifiable Alzheimer’s disease biomarkers changes. Sleep. 2017;40(5):zsx011.

    Google Scholar 

  29. Daulatzai MA. Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly. J Neurosci Res. 2015;93(12):1778–94.

    Article  CAS  PubMed  Google Scholar 

  30. Abbott SM, Videnovic A. Chronic sleep disturbance and neural injury: links to neurodegenerative disease. Nature Sci Sleep. 2016;8:55.

    Google Scholar 

  31. Qiu T, Luo X, Shen Z, Huang P, Xu X, Zhou J, Zhang M. Disrupted brain network in progressive mild cognitive impairment measured by eigenvector centrality mapping is linked to cognition and cerebrospinal fluid biomarkers. J Alzheimers Dis. 2016;54(4):1483–93.

    Article  CAS  PubMed  Google Scholar 

  32. Bucks RS, Olaithe M, Eastwood P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology. 2013;18(1):61–70.

    Article  PubMed  Google Scholar 

  33. Twigg GL, Papaioannou I, Jackson M, Ghiassi R, Shaikh J, Jaye J, Morrell MJ. Obstructive sleep apnea syndrome is associated with deficits in verbal but not visual memory. Am J Respir Crit Care Med. 2010;182(1):98–103.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Andreou G, Vlachos F, Makanikas K. Effects of chronic obstructive pulmonary disease and obstructive sleep apnea on cognitive functions: evidence for a common nature. Sleep Disorders. 2014;2014:1.

    Article  Google Scholar 

  35. Troussière AC, Charley CM, Salleron J, Richard F, Delbeuck X, Derambure P, Bombois S. Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2014;85(12):1405–8.

    Article  PubMed  Google Scholar 

  36. Canessa N, Castronovo V, Cappa SF, Aloia MS, Marelli S, Falini A, Ferini-Strambi L. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011;183(10):1419–26.

    Article  PubMed  Google Scholar 

  37. Ancoli-Israel S, Palmer BW, Cooke JR, Corey-Bloom J, Fiorentino L, Natarajan L, Loredo JS. Cognitive effects of treating obstructive sleep apnea in Alzheimer’s disease: a randomized controlled study. J Am Geriatr Soc. 2008;56(11):2076–81.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Osorio RS, Gumb T, Pirraglia E, Varga AW, Lu SE, Lim J, Alzheimer’s Disease Neuroimaging Initiative. Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 2015;84(19):1964–71.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Bassetti CL, Milanova M, Gugger M. Sleep-disordered breathing and acute ischemic stroke: diagnosis, risk factors, treatment, evolution, and long-term clinical outcome. Stroke. 2006;37(4):967–72.

    Article  PubMed  Google Scholar 

  40. Coutts SB, Wein TH, Lindsay MP, Buck B, Cote R, Ellis P, Gubitz G. Canadian Stroke Best Practice Recommendations: secondary prevention of stroke guidelines, update 2014. Int J Stroke. 2015;10(3):282–91.

    Article  PubMed  Google Scholar 

  41. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, Wilson JA. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(7):2160–236.

    Article  PubMed  Google Scholar 

  42. Chan W, Coutts SB, Hanly P. Sleep apnea in patients with transient ischemic attack and minor stroke: opportunity for risk reduction of recurrent stroke? Stroke. 2010;41(12):2973–5.

    Article  PubMed  Google Scholar 

  43. Mansukhani MP, Bellolio MF, Kolla BP, Enduri S, Somers VK, Stead LG. Worse outcome after stroke in patients with obstructive sleep apnea: an observational cohort study. J Stroke Cerebrovasc Dis. 2011;20(5):401–5.

    Article  PubMed  Google Scholar 

  44. Dong R, Dong Z, Liu H, Shi F, Du J. Prevalence, risk factors, outcomes, and treatment of obstructive sleep apnea in patients with cerebrovascular disease: a systematic review. J Stroke Cerebrovasc Dis. 2018;27(6):1471–80.

    Article  PubMed  Google Scholar 

  45. Lyons OD, Ryan CM. Sleep apnea and stroke. Can J Cardiol. 2015;31(7):918–27.

    Article  PubMed  Google Scholar 

  46. Alvarez-Sabín J, Romero O, Delgado P, Quintana M, Santamarina E, Ferré A, Sampol G. Obstructive sleep apnea and silent cerebral infarction in hypertensive individuals. J Sleep Res. 2018;27(2):232–9.

    Article  PubMed  Google Scholar 

  47. Kepplinger J, Barlinn K, Boehme AK, Gerber J, Puetz V, Pallesen LP, Bodechtel U. Association of sleep apnea with clinically silent microvascular brain tissue changes in acute cerebral ischemia. J Neurol. 2014;261(2):343–9.

    Article  PubMed  Google Scholar 

  48. Zhang Y, Wang W, Cai S, Sheng QI, Pan S, Shen F, Liu Y. Obstructive sleep apnea exaggerates cognitive dysfunction in stroke patients. Sleep Med. 2017;33:183–90.

    Article  PubMed  Google Scholar 

  49. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000;342(19):1378–84.

    Article  CAS  PubMed  Google Scholar 

  50. Aaronson JA, van Bennekom CA, Hofman WF, van Bezeij T, van den Aardweg JG, Groet E, Schmand B. Obstructive sleep apnea is related to impaired cognitive and functional status after stroke. Sleep. 2015;38(9):1431–7.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Cedernaes J, Rångtell FH, Axelsson EK, Yeganeh A, Vogel H, Broman JE, Benedict C. Short sleep makes declarative memories vulnerable to stress in humans. Sleep. 2015;38(12):1861–8.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Mitra A, Snyder AZ, Hacker CD, Pahwa M, Tagliazucchi E, Laufs H, Raichle ME. Human cortical–hippocampal dialogue in wake and slow-wave sleep. Proc Natl Acad Sci. 2016;113(44):E6868–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Poryazova R, Huber R, Khatami R, Werth E, Brugger P, Barath K, Bassetti CL. Topographic sleep EEG changes in the acute and chronic stage of hemispheric stroke. J Sleep Res. 2015;24(1):54–65.

    Article  PubMed  Google Scholar 

  54. Campos-Rodriguez F, Martinez-Garcia MA, de la Cruz-Moron I, Almeida-Gonzalez C, Catalan-Serra P, Montserrat JM. Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: a cohort study. Ann Intern Med. 2012;156(2):115–22.

    Article  PubMed  Google Scholar 

  55. Bravata DM, McClain V, Austin C, Ferguson J, Burrus N, Miech EJ, Yaggi HK. Diagnosing and managing sleep apnea in patients with chronic cerebrovascular disease: a randomized trial of a home-based strategy. Sleep Breath. 2017;21(3):713–25.

    Article  PubMed  PubMed Central  Google Scholar 

  56. McEvoy RD, Antic NA, Heeley E, Luo Y, Ou Q, Zhang X, Anderson CS. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. 2016;375(10):919–31.

    Article  PubMed  Google Scholar 

  57. Román GC, Verma AK, Zhang YJ, Fung SH. Idiopathic normal-pressure hydrocephalus and obstructive sleep apnea are frequently associated: a prospective cohort study. J Neurol Sci. 2018;395:164–8.

    Article  PubMed  Google Scholar 

  58. Salam OAA, Ghonimi NA, Ismail MH. Risk of obstructive sleep apnea in multiple sclerosis: frequency, clinical and radiological correlates. Mult Scler Relat Disord. 2019;28:184–8.

    Article  PubMed  Google Scholar 

  59. Gómez-González B, Domínguez-Salazar E, Hurtado-Alvarado G, Esqueda-Leon E, Santana-Miranda R, Rojas-Zamorano JA, Velázquez-Moctezuma J. Role of sleep in the regulation of the immune system and the pituitary hormones. Ann N Y Acad Sci. 2012;1261(1):97–106.

    Article  PubMed  Google Scholar 

  60. Braley TJ, Boudreau EA. Sleep disorders in multiple sclerosis. Curr Neurol Neurosci Rep. 2016;16(5):50–57.

    Google Scholar 

  61. Braley TJ, Kratz AL, Kaplish N, Chervin RD. Sleep and cognitive function in multiple sclerosis. Sleep. 2016;39(8):1525–33.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Macey PM, Henderson LA, Macey KE, Alger JR, Frysinger RC, Woo MA, Harper RM. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002;166(10):1382–7.

    Article  PubMed  Google Scholar 

  63. Longoni G, Rocca MA, Pagani E, Riccitelli GC, Colombo B, Rodegher M, … Filippi M. Deficits in memory and visuospatial learning correlate with regional hippocampal atrophy in MS. Brain Struct Funct. 2015;220(1):435–44.

    Google Scholar 

  64. Hulst HE, Steenwijk MD, Versteeg A, Pouwels PJ, Vrenken H, Uitdehaag BM, Barkhof F. Cognitive impairment in MS: impact of white matter integrity, gray matter volume, and lesions. Neurology. 2013;80(11):1025–32.

    Article  CAS  PubMed  Google Scholar 

  65. Shi Y, Chen L, Chen T, Li L, Dai J, Lui S, Gong Q. A meta-analysis of voxel-based brain morphometry studies in obstructive sleep apnea. Sci Rep. 2017;7(1):1–13.

    Google Scholar 

  66. Castronovo V, Scifo P, Castellano A, Aloia MS, Iadanza A, Marelli S, Falini A. White matter integrity in obstructive sleep apnea before and after treatment. Sleep. 2014;37(9):1465–75.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Liu F, Wang X. Diagnosis and treatment of epilepsy and sleep apnea comorbidity. Expert Rev Neurother. 2017;17(5):475–85.

    Article  CAS  PubMed  Google Scholar 

  68. Latreille V, Willment KC, Sarkis RA, Pavlova M. Neuropsychological correlates of obstructive sleep apnea severity in patients with epilepsy. Epileptic Disord. 2019;21(1):78–86.

    PubMed  Google Scholar 

  69. Yildiz FG, Tezer FI, Saygi S. Temporal lobe epilepsy is a predisposing factor for sleep apnea: a questionnaire study in video-EEG monitoring unit. Epilepsy Behav. 2015;48:1–3.

    Article  PubMed  Google Scholar 

  70. Ismayilova V, Demir AU, Tezer FI. Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res. 2015;115:119–25.

    Article  PubMed  Google Scholar 

  71. Crespel A, Baldy-Moulinier M, Coubes P. The relationship between sleep and epilepsy in frontal and temporal lobe epilepsies: practical and physiopathologic considerations. Epilepsia. 1998;39(2):150–7.

    Article  CAS  PubMed  Google Scholar 

  72. Caspari SS, Strand EA, Kotagal S, Bergqvist C. Obstructive sleep apnea, seizures, and childhood apraxia of speech. Pediatr Neurol. 2008;38(6):422–5.

    Article  PubMed  Google Scholar 

  73. Leung H, Kwan P, Elger CE. Finding the missing link between ictal bradyarrhythmia, ictal asystole, and sudden unexpected death in epilepsy. Epilepsy Behav. 2006;9(1):19–30.

    Article  CAS  PubMed  Google Scholar 

  74. Andrade EO, Arain A, Malow BA. Partial epilepsy presenting as apneic seizures without posturing. Pediatr Neurol. 2006;35(5):359–62.

    Article  PubMed  Google Scholar 

  75. Lee HW, Hong SB, Tae WS, Seo DW, Kim SE. Partial seizures manifesting as apnea only in an adult. Epilepsia. 1999;40(12):1828–31.

    Article  CAS  PubMed  Google Scholar 

  76. Malow BA, Weatherwax KJ, Chervin RD, Hoban TF, Marzec ML, Martin C, Binns LA. Identification and treatment of obstructive sleep apnea in adults and children with epilepsy: a prospective pilot study. Sleep Med. 2003;4(6):509–15.

    Article  PubMed  Google Scholar 

  77. Oliveira EF, Nacif SR, Urbano JJ, Silva AS, Oliveira CS, Perez EA, Oliveira LVF. Sleep, lung function, and quality of life in patients with myasthenia gravis: a cross-sectional study. Neuromuscul Disord. 2017;27(2):120–7.

    Article  PubMed  Google Scholar 

  78. Amino A, Shiozawa Z, Nagasaka T, Shindo K, Ohashi K, Tsunoda S, Shintani S. Sleep apnoea in well-controlled myasthenia gravis and the effect of thymectomy. J Neurol. 1998;245(2):77–80.

    Article  CAS  PubMed  Google Scholar 

  79. Yeh JH, Lin CM, Chen WH, Chiu HC. Effects of double filtration plasmapheresis on nocturnal respiratory function in myasthenic patients. Artif Organs. 2013;37(12):1076–9.

    Article  CAS  PubMed  Google Scholar 

  80. Heo SJ, Jun JS, Park D, Lee HW, Kim JS, Park JS. Characteristics of obstructive sleep apnea in myasthenia gravis patients: a single-center study. Neurol Sci. 2019;40(4):719–24.

    Article  PubMed  Google Scholar 

  81. Teramoto K, Kuwabara M, Matsubara Y. Respiratory failure due to vocal cord paresis in myasthenia gravis. Respiration. 2002;69(3):280–2.

    Article  PubMed  Google Scholar 

  82. Baillieul S, Revol B, Jullian-Desayes I, Joyeux-Faure M, Tamisier R, Pépin JL. Diagnosis and management of central sleep apnea syndrome. Expert Rev Respir Med. 2019;13(6):545–57.

    Article  CAS  PubMed  Google Scholar 

  83. Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: pathophysiology and treatment. Chest. 2007;131(2):595–607.

    Article  PubMed  Google Scholar 

  84. Dempsey JA. Central sleep apnea: misunderstood and mistreated! F1000Research. 2019;8:F1000 Faculty Rev-981.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Javaheri S, Dempsey JA. Central sleep apnea. Compr Physiol. 2013;3(1):141–63.

    Article  CAS  PubMed  Google Scholar 

  86. Dauger S, Pattyn A, Lofaso F, Gaultier C, Goridis C, Gallego J, Brunet JF. Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways. Development. 2003;130(26):6635–42.

    Article  CAS  PubMed  Google Scholar 

  87. Thalhofer S, Dorow P. Central sleep apnea. Respiration. 1997;64(1):2–9.

    Article  CAS  PubMed  Google Scholar 

  88. Severinghaus J. Ondine’s curse: failure of respiratory center automaticity while awake. Clin Res. 1962;10:122.

    Google Scholar 

  89. Randerath W, Verbraecken J, Andreas S, Arzt M, Bloch KE, Brack T, Levy P. Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep. Eur Respir J. 2017;49(1):1600959.

    Article  PubMed  Google Scholar 

  90. Orr JE, Malhotra A, Sands SA. Pathogenesis of central and complex sleep apnoea. Respirology. 2017;22(1):43–52.

    Article  PubMed  Google Scholar 

  91. Albdewi MA, Liistro G, El Tahry R. Sleep-disordered breathing in patients with neuromuscular disease. Sleep Breath. 2018;22(2):277–86.

    Article  PubMed  Google Scholar 

  92. White JE, Drinnan MJ, Smithson AJ, Griffiths CJ, Gibson GJ. Respiratory muscle activity and oxygenation during sleep in patients with muscle weakness. Eur Respir J. 1995;8(5):807–14.

    Article  CAS  PubMed  Google Scholar 

  93. George CFP. Neuromuscular disorders. In: Kryger MH, Roth T, Dement WC, editors. Principles and practices of sleep medicine. Philadelphia: WB Saunders Company; 2000. p. 1087–92.

    Google Scholar 

  94. Aboussouan LS. Sleep-disordered breathing in neuromuscular disease. Am J Respir Crit Care Med. 2015;191(9):979–89.

    Article  PubMed  Google Scholar 

  95. Martins RT, Eckert DJ. Central sleep apnea due to other medical disorders. Sleep Med Clin. 2014;9(1):57–67.

    Article  Google Scholar 

  96. Braley TJ, Segal BM, Chervin RD. Sleep-disordered breathing in multiple sclerosis. Neurology. 2012;79(9):929–36.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Schütz SG, Lisabeth LD, Hsu CW, Kim S, Chervin RD, Brown DL. Central sleep apnea is uncommon after stroke. Sleep Med. 2021;77:304–6.

    Article  PubMed  Google Scholar 

  98. Cormican LJ, Higgins S, Davidson AC, Howard R, Williams AJ. Multiple system atrophy presenting as central sleep apnoea. Eur Respir J. 2004;24(2):323–5.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Kyrenia, Kyrenia, Turkish Republic of North Cyprus (TRNC), Kyrenia, Cyprus

    Pınar Gelener

  2. Department of Pulmonary Diseases, Cyprus International University, Nicosia, Turkish Republic of North Cyprus (TRNC), Nicosia, Cyprus

    Fusun Yıldız

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  1. Pınar Gelener
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Editors and Affiliations

  1. Department of Otorhinolaryngology, Eskişehir Osmangazi University, Eskisehir, Türkiye

    Cemal Cingi

  2. Department of Pulmonology, Celal Bayar University, Manisa, Türkiye

    Arzu Yorgancıoğlu

  3. Department of Otorhinolaryngology, Kırıkkale University, Kırıkkale, Türkiye

    Nuray Bayar Muluk

  4. Federal University of Bahia School of Medicine and ProAR Foundation, Salvador - Bahia, Brazil

    Alvaro A. Cruz

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Gelener, P., Yıldız, F. (2023). Obstructive Sleep Apnea. In: Cingi, C., Yorgancıoğlu, A., Bayar Muluk, N., Cruz, A.A. (eds) Airway diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-22483-6_130-1

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