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Circadian Rhythm Manipulations: Implications on Behavioral Restoration in Central Nervous System Insults

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Sleep and Clocks in Aging and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 18))

Abstract

Ambient light is a crucial environmental factor that influences physiology and behavior in all organisms including human beings. A fair understanding of the importance of circadian rhythms and timekeeping would enable us to develop strategies for the management of disrupted circadian rhythm-associated disorders such as depression, Alzheimer’s, and Parkinson’s diseases. Circadian manipulation protocols such as bright light exposure, acute sleep deprivation and photoperiod manipulation have been reported to be beneficial in humans and animal models. This chapter briefly summarizes the current knowledge on the efficacious role of circadian rhythm manipulation strategies in facilitating behavioral recovery and the possible underlying mechanisms. We have also tried to highlight the limitations and implications of futuristic combinatorial circadian rhythm manipulation and pharmacological approaches in the management of chronodisruption-related disorders.

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Acknowledgments

The study was funded by Science and Engineering Research Board (SERB), New Delhi (EMR/2017/001237).

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  1. Duttagupta Subhadeep

    Present address: Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, USA

Authors and Affiliations

  1. Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Hosur Road, Bangalore, 560029, India

    Duttagupta Subhadeep, B. N. Srikumar, B. S. Shankaranarayana Rao & Bindu M. Kutty

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Correspondence to Bindu M. Kutty .

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  1. Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Science, University of Hyderabad, Hyderabad, Telangana, India

    Anita Jagota

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All experimental protocols were approved by the Institute Animal Ethics Committee (AEC/66/403/N.P.) following the guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Government of India, at the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru.

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Subhadeep, D., Srikumar, B.N., Shankaranarayana Rao, B.S., Kutty, B.M. (2023). Circadian Rhythm Manipulations: Implications on Behavioral Restoration in Central Nervous System Insults. In: Jagota, A. (eds) Sleep and Clocks in Aging and Longevity. Healthy Ageing and Longevity, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-031-22468-3_16

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