Abstract
Angiogenesis, or new blood vessels formation, comprises a series of tight regulated and coordinated steps guided by the balance between proangiogenic and antiangiogenic signals. Although physiological angiogenesis occurs in some context, such as embryogenesis or wound healing, it is a very restricted process in adults. A deregulated angiogenesis is associated to several pathologies such as cancer, arthritis, or age-related macular degeneration. For this purpose, plenty of compounds from natural sources have been studied and their antiangiogenic potential has been demonstrated. Most of them are isolated from plants, such as the major catechin found in green tea, epigallocatechin-3-gallate (EGCG), or the isoflavonoid genistein. Nevertheless, compounds with antiangiogenic potential can be found in several species of animals, fungi, algae, or bacteria, for instance, aeroplysinin-1, AD0157, carrageenan derivates, and rapamycin, respectively. The extracellular matrix (ECM) remodeling plays a key role in the formation of new blood vessels. The degradation of the ECM components not only provides a structural scaffold for the nascent vessels, but it is also strongly involved in endothelial cell signaling, promoting or inhibiting this complex process. In this regard, targeting the ECM components entails an interesting therapeutic strategy for the treatment of angiogenesis-related diseases. This book chapter is an updated overview of natural compounds with an antiangiogenic effect with the capability to target one or more ECM components.
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No potential conflicts of interest were disclosed.
Funding
This work was supported by grants PID2019-105010RB-I00 (Spanish Ministry of Science, Innovation and Universities), UMA18-FEDERJA-220, UMA18-FEDERJA-267, and PY20_00257 (Andalusian Government and FEDER) and funds from PAIDI group BIO 267 (Andalusian Government). The “CIBER de Enfermedades Raras” and “CIBER de Enfermedades Cardiovasculares” are initiatives from the ISCIII (Spain). Melissa García Caballero was supported by Beatriz Galindo Program from the Spanish Ministry of Science and Innovation and Manuel Bernal was supported by Juan de la Cierva—Incorporación Program (IJC2018-037657-I), Spanish Ministry of Science and Innovation. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.
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Carrillo, P. et al. (2023). Extracellular Matrix Remodeling Enzymes as Targets for Natural Antiangiogenic Compounds. In: Papadimitriou, E., Mikelis, C.M. (eds) Matrix Pathobiology and Angiogenesis. Biology of Extracellular Matrix, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-031-19616-4_6
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