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Lab-on-a-Chip Devices for Medical Diagnosis II: Strategies for Pathogen Detection

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Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine

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Abstract

The development of lab-on-a-chip technology is regarded as one of the most potent and reliable technologies for rapid and early detection of the pathogen with portable and on-site detection devices, the so-called point-of-care (PoC) detection systems. These are essentially easy to handle and cheap and offer rapid sample-to-answer results to nontechnical operators in a fast and accurate manner. A summary to provide an explanation about why lab-on-a-chip technology is one of the strategies for early detection of pathogens for medical diagnosis has been presented. The fabrication of the devices includes the three most important factors that are described. The devices are also implemented for the detection of various pathogens such as bacteria, protozoa, and virus, and also how each of the systems has specific ways to get the results. Furthermore, newly established detection sensing principles and application of the lab-on-a-chip and microfluidic devices are presented, and the remaining technical challenges and limitations are considered.

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Acknowledgments

The Basic Science Research Program supported this work through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2018R1A6A1A03025582, 2019R1D1A3A03103828, and 2022R1I1A3063302), Republic of Korea.

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Authors and Affiliations

  1. Department of Biosystems Engineering, Institute of Forest Science, Kangwon National University, Chuncheon, Republic of Korea

    Rachmi Luthfikasari, Dinesh K. Patel, Keya Ganguly, Sayan Deb Dutta & Ki-Taek Lim

  2. Interdisciplinary Program in Smart Agriculture, Kangwon National University, Chuncheon, Republic of Korea

    Tejal V. Patil & Ki-Taek Lim

Authors
  1. Rachmi Luthfikasari
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  2. Tejal V. Patil
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  3. Dinesh K. Patel
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  4. Keya Ganguly
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  5. Sayan Deb Dutta
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  6. Ki-Taek Lim
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Correspondence to Ki-Taek Lim .

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Editors and Affiliations

  1. Department of Biosystems Engineering, Kangwon National University, Chuncheon, Korea (Republic of)

    Ki-Taek Lim

  2. Agricultural Research Center, Plant Pathology Research Institute, Giza, Egypt

    Kamel A. Abd-Elsalam

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Luthfikasari, R., Patil, T.V., Patel, D.K., Ganguly, K., Dutta, S.D., Lim, KT. (2023). Lab-on-a-Chip Devices for Medical Diagnosis II: Strategies for Pathogen Detection. In: Lim, KT., Abd-Elsalam, K.A. (eds) Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine. Springer, Cham. https://doi.org/10.1007/978-3-031-16084-4_12

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