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Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors

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The Renin Angiotensin System in Cardiovascular Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 24))

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Abstract

In 1934, the discovery of angiotensin II opened an Eldorado in the field of the cardiovascular system. Until today, this Eldorado is still evolving due to the implication of this octapeptide, not only in normal physiology but also in its effect on the remodeling of the cardiovascular system. The intense scientific research led to the discovery of components that regulates the conversion of Angiotensin I to angiotensin II including angiotensin II converting enzyme and chymase-dependent production of angiotensin II. One important advancement is discovering an inhibitor of the angiotensin II converting enzyme, which is the most clinically used antihypertensive drug. Identifying the receptors of angiotensin II, AT1, and AT2, also led to determining the signaling pathways of these two receptors and their contribution to the regulation of the cardiovascular system in health and disease. This made it possible to develop two specific AT1 and AT2 receptor antagonists. Its is not until recently that the AT1 receptor antagonist, losartan, is used as an antihypertensive drug. The role of the AT2 receptor in the angiotensin II effect is still a matter of debate. These two receptors were also found to be localized at the nuclear envelope membranes, and the normal crosstalk between the plasma and the nuclear envelope membranes angiotensin II receptors seems to be an important factor in the angiotensin II effect. Remodeling this crosstalk may contribute to the angiotensin II effect in cardiovascular diseases. (Dedicated to Prof. Domenico Regoli, a pioneer in the pharmacology of the renin angiotensin system).

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Acknowledgements

This work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC).

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  1. Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada

    Danielle Jacques & Ghassan Bkaily

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  1. Danielle Jacques
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  2. Ghassan Bkaily
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Correspondence to Danielle Jacques or Ghassan Bkaily .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Manitoba, MB, Canada

    Naranjan S. Dhalla

  2. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB, Canada

    Sukhwinder K. Bhullar

  3. California State University Los Angeles, Los Angeles, CA, USA

    Anureet K. Shah

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Jacques, D., Bkaily, G. (2023). Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors. In: Dhalla, N.S., Bhullar, S.K., Shah, A.K. (eds) The Renin Angiotensin System in Cardiovascular Disease. Advances in Biochemistry in Health and Disease, vol 24. Springer, Cham. https://doi.org/10.1007/978-3-031-14952-8_4

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