Skip to main content

Nutritional Anemia in Pregnancy and Lactation

  • Chapter
  • First Online:
Nutritional Anemia

Part of the book series: Nutrition and Health ((NH))

Abstract

Worldwide, maternal anemia affects over 40% of pregnant and lactating women and is considered a major public health burden. During pregnancy, anemia is associated with increased maternal infections, fatigue, decreased cognitive function, preterm birth, and elevated maternal morbidity and mortality. Risks to the child include poor fetal growth and development, premature birth, still birth, increased morbidity and mortality, and poor cognitive development. Anemia during lactation adversely affects maternal postpartum health and recovery, breast milk quality, and infant health. Maternal anemia has multiple causes including insufficient intake of specific nutrients needed to meet the demands for synthesis of hemoglobin and erythrocytes. The most crucial nutrient is iron, but others are also important, especially vitamins A, B2 (riboflavin), B6 (pyridoxine), B12 (cobalamin), C, D, and E, folate, and copper. In addition, nutritional anemia has secondary causes including infection, poor quality of antenatal and postnatal care, food insecurity, low socioeconomic status, poor quality implementation of maternal nutrition programs, genetic factors, and the gut microbiome. The World Health Assembly (WHA) Global Nutrition Target is to reduce anemia in women of reproductive age by 50% by 2025, and current progress is lagging. The simplest and most apparent of interventions is iron supplementation or multiple micronutrient supplementation (MMS). Other interventions include food fortification, dietary diversity, agricultural and food security, and conditional cash transfer programs. Although these can be effective, they have typically modest to minimal effects due to poor implementation, even for direct supplementation programs. There is an urgent need for solutions in the context of precision medicine and precision public health and to embrace digital health and address issues of frontline health worker performance and adopt more preventive and promotive approaches with strong community engagement. Such changes will likely require a change in how programs are designed and deployed, focusing more on local innovations, e.g., from and with communities, rather than traditional top-down approaches from global organizations that have been unable to meet the needs. The post-pandemic world is an opportunity to take stock in what has worked, and not worked, and forge innovations and novel pathways to create impact at scale.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. World Health Organization. World-wide prevalence of anaemia 1993–2005: WHO global database on anaemia. Geneva, Switzerland: WHO Press; 2005.

    Google Scholar 

  2. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data. Lancet Glob Health. 2013;1(1):e16–25. https://doi.org/10.1016/s2214-109x(13)70001-9.

    Article  Google Scholar 

  3. Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123–35. https://doi.org/10.1016/s0140-6736(10)62304-5.

    Article  Google Scholar 

  4. The global prevalence of anaemia in 2011. Geneva: World Health Organization; 2015. http://apps.who.int/iris/bitstream/10665/177094/1/9789241564960_eng.pdf?ua=1&ua=1. Accessed 21 May 2022.

  5. Assessing the iron status of populations. Second edition including literature reviews. Report of a Joint World Health Organization/Centers for Disease Control and Prevention technical consultation on the assessment of iron status at the population level, Geneva, Switzerland, 6–8 April 2004. Geneva: World Health Organization; 2007. http://apps.who.int/iris/bitstream/10665/75368/1/9789241596107_eng.pdf?ua=1&ua=1. Accessed 21 May 2022.

  6. Petry N, Olofin I, Hurrell RF, Boy E, Wirth JP, Moursi M, Donahue AM, Rohner F. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: a systematic analysis of national surveys. Nutrients. 2016;8:693.

    Article  Google Scholar 

  7. World Health Organization. Daily iron supplementation in children 6–23 months of age. https://apps.who.int/iris/rest/bitstreams/909299/retrieve. Accessed 21 May 2022.

  8. World Health Organization. Who recommendations on antenatal care for a positive pregnancy experience. https://apps.who.int/iris/rest/bitstreams/1064182/retrieve. Accessed 21 May 2022.

  9. Gupta PM, Hamner HC, Suchdev PS, Flores-Ayala R, Mei Z. Iron deficiency and adequacy in young children, non-pregnant, and pregnant women in the United States. Am J Clin Nutr. 2017;106:1640S–6S.

    Article  Google Scholar 

  10. Milman N, Taylor C, Merkel J, Brannon P. Iron status in pregnant women and women of reproductive age in Europe. Am J Clin Nutr. 2017;106:1655S–62S.

    Article  Google Scholar 

  11. Taylor CL, Brannon PM. Introduction to workshop on iron screening and supplementation in iron-replete pregnant women and young children. Am J Clin Nutr. 2017;106:1547S–54S.

    Article  Google Scholar 

  12. Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017;106:1567S–74S.

    Article  Google Scholar 

  13. Lönnerdal B. Development of iron homeostasis in infants and young children. Am J Clin Nutr. 2017;106:1575S–80S.

    Article  Google Scholar 

  14. Bothwell TH. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr. 2000;72:257S–64S.

    Article  CAS  Google Scholar 

  15. Zhang C, Rawal S. Dietary iron intake, iron status and gestational diabetes. Am J Clin Nutr. 2017;106:1672S–80S.

    Article  Google Scholar 

  16. Paganini D, Zimmermann MB. The effects of iron fortification and supplementation on the gut microbiome and diarrhea in infants and children: a review. Am J Clin Nutr. 2017;106:1688S–93S.

    Article  Google Scholar 

  17. Schreir SL. Approach to the adult patient with anemia. In Mentzer WC, editor. Waltham, MA: UpToDate Inc.; 2018.

    Google Scholar 

  18. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 2011. https://apps.who.int/iris/bitstream/handle/10665/85839/WHO_NMH_NHD_MNM_11.1_eng.pdf?sequence=22&isAllowed=y. Accessed 21 May 2022.

  19. Balarajan Y, Ramakrishnan U, Özaltin E, et al. Nutritional anaemias: tools for effective prevention and control. Geneva: World Health Organization; 2017. Licence: CC BY-NC-SA 3.0 IGO.

    Google Scholar 

  20. Centers for Disease Control. CDC criteria for anemia n children and childbearing-aged women. MMWR Morb MortalWkly Rep. 1989;38:400–4.

    Google Scholar 

  21. World Health Organization. Pregnancy, childbirth, postpartum and newborn care: a guide for essential practice. Geneva: World Health Organization; 2003.

    Google Scholar 

  22. World Health Organization. Handbook: IMCI integrated management of childhood illness. Geneva: World Health Organization; 2005.

    Google Scholar 

  23. Chalco JP, Huicho L, Alamo C, et al. Accuracy of clinical pallor in the diagnosis of anaemia in children: a meta-analysis. BMC Pediatr. 2005;5:46.

    Article  Google Scholar 

  24. International Nutritional Anemia Consultative Group (INACG). Adjusting hemoglobin values in program surveys. INACG/USAID; 2002.

    Google Scholar 

  25. Niforou A, Konstantinidou V, Naska A. Genetic variants shaping inter-individual differences in response to dietary intakes—a narrative review of the case of vitamins. Front Nutr. 2020;7:558598. https://doi.org/10.3389/fnut.2020.558598.

    Article  CAS  Google Scholar 

  26. Vricella LK. Emerging understanding and measurement of plasma volume expansion in pregnancy. Am J Clin Nutr. 2017;106:1620S–5S.

    Article  Google Scholar 

  27. Colomer J, Colomer C, Gutierrez D, Jubert A, Nolasco A, Donat J, et al. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr Perinat Epidemiol. 1990;4(2):196–204.

    Article  CAS  Google Scholar 

  28. Kilbride J, Baker TG, Parapia LA, Khoury SA, Shuqaidef SW, Jerwood D. Anaemia during pregnancy as a risk factor for iron deficiency anaemia in infancy: a case-control study in Jordan. Int J Epidemiol. 1999;28(3):461–8. https://doi.org/10.1093/ije/28.3.461.

  29. Ziegler EE, Nelson SE, Jeter JM. Iron stores of breastfed infants during the first year of life. Nutrients. 2014;6(5):2023–34. https://doi.org/10.3390/nu6052023.

    Article  CAS  Google Scholar 

  30. Petry N, Olofin I, Hurrell R, Boy E, Wirth J, Moursi M, et al. The proportion of anemia associated with iron deficiency in low, medium, and high human development index countries: a systematic analysis of national surveys. Nutrients. 2016;8(11):693–701.

    Article  Google Scholar 

  31. Karakochuk C, Whitfield K, Barr S, Lamers Y, Devlin A, Vercauteren S, et al. Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia. J Nutr. 2015;145(1):134–42. https://doi.org/10.3945/jn.114.198945.

    Article  CAS  Google Scholar 

  32. Wieringa F, Dahl M, Chamnan C, Poirot E, Kuong K, Sophonneary P, et al. The high prevalence of anemia in Cambodian children and women cannot be satisfactorily explained by nutritional deficiencies or hemoglobin disorders. Nutrients. 2016;8(6):348–60. https://doi.org/10.3390/nu8060348.

    Article  CAS  Google Scholar 

  33. Semba RD, Bloem MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr. 2002;56(4):271–81. https://doi.org/10.1038/sj.ejcn.1601320.

    Article  CAS  Google Scholar 

  34. Michelazzo FB, Oliveira JM, Stefanello J, Luzia LA, Rondo PH. The influence of vitamin A supplementation on iron status. Nutrients. 2013;5(11):4399–413. https://doi.org/10.3390/nu5114399.

    Article  CAS  Google Scholar 

  35. Maia SB, Souza ASR, de Fátima Costa Caminha M, da Silva SL, de Sá Barreto Luna Callou Cruz R, Dos Santos CC, Filho MB. Vitamin A and pregnancy: a narrative review. Nutrients. 2019;11(3):681. https://doi.org/10.3390/nu11030681.

    Article  CAS  Google Scholar 

  36. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr. 2000.

    Google Scholar 

  37. Rohner F, Zimmermann MB, Wegmueller R, Tschannen AB, Hurrell RF. Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Cote d’Ivoire. Br J Nutr. 2007;97(5):970–6. https://doi.org/10.1017/s0007114507665180.

    Article  CAS  Google Scholar 

  38. Powers HJ. Riboflavin (vitamin B-2) and health. Am J Clin Nutr. 2003;77(6):1352–60.

    Article  CAS  Google Scholar 

  39. Field MS, Kamynina E, Chon J, Stover PJ. Nuclear folate metabolism. Annu Rev Nutr. 2018;38:219–43. https://doi.org/10.1146/annurev-nutr-071714-034441.

    Article  CAS  Google Scholar 

  40. Allen LH. Causes of vitamin B12 and folate deficiency. Food Nutr Bull. 2008;29(2 Suppl):S20–34.

    Article  Google Scholar 

  41. McLean E, de Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull. 2008;29(2 Suppl):S38–51. https://doi.org/10.1177/15648265080292S107.

    Article  Google Scholar 

  42. Metz J. A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull. 2008;29(2 Suppl):S74–85.

    Article  Google Scholar 

  43. Page CM, Patel A, Hibberd PL. Does smoke from biomass fuel contribute to anemia in pregnant women in Nagpur, India? A cross-sectional study. PLoS One. 2015;10(5):e0127890. https://doi.org/10.1371/journal.pone.0127890.

    Article  CAS  Google Scholar 

  44. Atkinson MA, Melamed ML, Kumar J, Roy CN, Miller ER 3rd, Furth SL, et al. Vitamin D, race, and risk for anemia in children. J Pediatr. 2014;164(1):153–8.e151. https://doi.org/10.1016/j.jpeds.2013.08.060.

    Article  CAS  Google Scholar 

  45. Turnlund JR. Copper. In: Shils ME, Olson JA, Shike M, Ross AC, editors. Modern nutrition in health and disease. Philadelphia: Lippincott Williams & Wilkins; 1999. p. 241–52.

    Google Scholar 

  46. Tussing-Humphreys L, Pusatcioglu C, Nemeth E, Braunschweig C. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin. J Acad Nutr Diet. 2012;112(3):391–400. https://doi.org/10.1016/j.jada.2011.08.038.

    Article  CAS  Google Scholar 

  47. Aeberli I, Hurrell RF, Zimmermann MB. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes. 2009;33(10):1111–7. https://doi.org/10.1038/ijo.2009.146.

    Article  CAS  Google Scholar 

  48. Cepeda-Lopez AC, Aeberli I, Zimmermann MB. Does obesity increase risk for iron deficiency? A review of the literature and the potential mechanisms. Int J Vit Nutr Res. 2010;80(45):263–70. https://doi.org/10.1024/0300-9831/a000033.

    Article  CAS  Google Scholar 

  49. Gordeuk VR, Brannon PM. Ethnic and genetic factors of iron status in women of reproductive age. Am J Clin Nutr. 2017;106:1594S–9S.

    Article  Google Scholar 

  50. Suzuki M, Wang T, Garretto D, Isasi CR, Cardoso WV, Greally JM, Quadro L. Disproportionate Vitamin A deficiency in women of specific ethnicities linked to differences in allele frequencies of vitamin A-related polymorphisms. Nutrients. 2021;13:1743. https://doi.org/10.3390/nu13061743.

    Article  CAS  Google Scholar 

  51. Szili B, Szabó B, Horváth P, Bakos B, Kirschner G, Kósa JP, Toldy E, Putz Z, Lakatos P, Tabák A, Takács A. Impact of genetic influence on serum total- and free 25-hydroxyvitamin-D in humans. J Steroid Biochem Mol Biol. 2018;183:62–7. https://doi.org/10.1016/j.jsbmb.2018.05.007.

    Article  CAS  Google Scholar 

  52. Moorthy D, Merrill R, Namaste S. Iannotti L The impact of nutrition-specific and nutrition-sensitive interventions on hemoglobin concentrations and anemia: a meta-review of systematic reviews. Adv Nutr. 2020;11:1631–45.

    Article  Google Scholar 

  53. Allen LH, Peerson JM, Olney DK. Provision of multiple rather than two or fewer micronutrients more effectively improves growth and other outcomes in micronutrient deficient children and adults. J Nutr. 2009;139:1022–30.

    Article  CAS  Google Scholar 

  54. Bourassa MW, Osendarp SJM, Adu-Afarwuah S, Ahmed S, Ajello C, Bergeron G, et al. Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries. Ann N Y Acad Sci. 2019;1444(1):6–21.

    Article  Google Scholar 

  55. Oh C, Keats EC, Bhutta ZA. Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: a systematic review and meta-analysis. Nutrients. 2020;12(2):491. https://doi.org/10.3390/nu12020491.

    Article  CAS  Google Scholar 

  56. Gomes F, Agustina R, Black RE, Christian P, Dewey KG, Kraemer K, Shankar AH, Smith ER, Thorne-Lyman A, Tumilowicz A, Bourassa MW. (2022). Multiple micronutrient supplements versus iron-folic acid supplements and maternal anemia outcomes: an iron dose analysis. Ann N Y Acad Sci. 2022. https://doi.org/10.1111/nyas.14756.

  57. McCauley ME, van den Broek N, Dou L, Othman M. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst Rev. 2015;(10):CD008666.

    Google Scholar 

  58. Swaminathan S, Thomas T, Kurpad AV. B-vitamin interventions for women and children in low-income populations. Curr Opin Clin Nutr Metab Care. 2015;18:295–306.

    Article  CAS  Google Scholar 

  59. Villar J, Merialdi M, Gulmezoglu AM, Abalos E, Carroli G, Kulier R, de Onis M. Nutritional interventions during pregnancy for the prevention or treatment of maternal morbidity and preterm delivery: an overview of randomized controlled trials. J Nutr. 2003;133(5 Suppl 2):1606S–25S.

    Article  CAS  Google Scholar 

  60. Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) Study Group, Shankar AH, Jahari AB, Sebayang SK, Aditiawarman, Apriatni M, Harefa B, Muadz H, Soesbandoro SD, Tjiong R, Fachry A, Shankar AV, Atmarita, Prihatini S, Sofia G. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet. 2008;371:215–27.

    Article  Google Scholar 

  61. Smith ER, Shankar AH, Wu LS, Aboud S, Adu-Afarwuah S, Ali H, et al. Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. Lancet Glob Health. 2017;5(11):e1090–100.

    Article  Google Scholar 

  62. Long Y, Liang F, Guo R, Zhu C, Zhao X, Wang X, Liu F, Jiang M, Liang Q, Zeng S, Han M, Qin J, Li S, Li S, Yang H. Gut microbiota signatures in gestational anemia. Front Cell Infect Microbiol. 2021;11:549678. https://doi.org/10.3389/fcimb.2021.549678.

    Article  CAS  Google Scholar 

  63. Permatasari IK, Syah IF, Guntjoro R, Sadhu S, Odipatra R, Satria A, Widowati F, Nurjannah, Ramdhani NI, Shankar AH. Better quality for better impact: optimized packaging and appearance of maternal multiple micronutrient supplements for pregnant women in Indonesia. 2020. https://sightandlife.org/wp-content/uploads/2020/04/SightandLife_SpecialReport_MMS_2020_Better-Quality-for-Better-Impact.pdf. Accessed 22 May 2022.

  64. Haddad SM, Souza RT, Cecatti JG, Barreix M, Tamrat T, Gulas C, Mehl G, Syah IF, Shankar AH, Tuncalp O. Building a mobile application of the WHO antenatal care recommendations: methodological intersection between evidence, clinical logic and digital technology. J Med Internet Res. 2020;22:e16355.

    Article  Google Scholar 

  65. Lubell-Doughtie P, Bhatt S, Wong R, Shankar AH. Transforming rapid diagnostic tests for precision public health: open guidelines for manufacturers and users. JMIR Biomed Eng. 2022;7(2):e26800. https://doi.org/10.2196/26800.

  66. Shankar AV, Zaitu A, Kadha JK, Sebayang SK, Apriatni M, Sulastri A, Sunarsih E, Shankar AH. Programmatic effects of a large scale multiple micronutrient supplementation trial in Indonesia: using community facilitators as intermediaries for behavior change. Food Nutr Bull. 2009;30:S207–14.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anuraj H. Shankar .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Shankar, A.H., Agustina, R., Setiyawati, Y. (2022). Nutritional Anemia in Pregnancy and Lactation. In: Karakochuk, C.D., Zimmermann, M.B., Moretti, D., Kraemer, K. (eds) Nutritional Anemia. Nutrition and Health. Springer, Cham. https://doi.org/10.1007/978-3-031-14521-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-14521-6_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14520-9

  • Online ISBN: 978-3-031-14521-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics