Abstract
Ankylosing spondylitis (AS) is an HLA-B27 associated rheumatoid disease and prototypical spondyloarthritis. In addition to cardiopulmonary comorbidities, axial spondyloarthritis is one of the major clinical features among AS. Spine is the primary skeletal site involved, starting from sacroiliac joint and progressing rostrally to lumbar then cervical spine. Cervical spine fracture is a common complication in AS patients that usually cause spinal cord injury and significant neurologic deterioration. Cervical spine deformity is another troublesome condition that leads to severe disability and poor health-related quality of life in AS patients. Cutting-edge managements for AS-involved cervical spine disease will be further described in the chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Zhu W, He X, Cheng K, et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res. 2019;7:22.
Britto NMF, Renor BS, Ghizoni E, Tedeschi H, Joaquim AF. Spine surgery in patients with ankylosing spondylitis. Rev Assoc Med Bras (1992). 2018;64(4):379–83.
Taurog JD, Chhabra A, Colbert RA. Ankylosing spondylitis and axial Spondyloarthritis. N Engl J Med. 2016;374(26):2563–74.
Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DC, Sturrock RD. Ankylosing spondylitis and HL-A 27. Lancet. 1973;1(7809):904–7.
Reveille JD. An update on the contribution of the MHC to AS susceptibility. Clin Rheumatol. 2014;33(6):749–57.
Reveille JD. The genetic basis of spondyloarthritis. Ann Rheum Dis. 2011;70(Suppl 1):i44–50.
Reveille JD, Witter JP, Weisman MH. Prevalence of axial spondylarthritis in the United States: estimates from a cross-sectional survey. Arthritis Care Res (Hoboken). 2012;64(6):905–10.
Julian-Santiago F, Garcia-Garcia C, Garcia-Olivera I, Goycochea-Robles MV, Pelaez-Ballestas I. Epidemiology of rheumatic diseases in Mixtec and Chontal indigenous communities in Mexico: a cross-sectional community-based study. Clin Rheumatol. 2016;35(Suppl 1):35–42.
Zeng SY, Gong Y, Zhang YP, et al. Changes in the prevalence of rheumatic diseases in Shantou, China, in the past three decades: a COPCORD study. PLoS One. 2015;10(9):e0138492.
Montoya J, Matta NB, Suchon P, et al. Patients with ankylosing spondylitis have been breast fed less often than healthy controls: a case-control retrospective study. Ann Rheum Dis. 2016;75(5):879–82.
Maas F, Spoorenberg A, Brouwer E, et al. Radiographic damage and progression of the cervical spine in ankylosing spondylitis patients treated with TNF-alpha inhibitors: facet joints vs. vertebral bodies. Semin Arthritis Rheum. 2017;46(5):562–8.
Davis JC Jr. Understanding the role of tumor necrosis factor inhibition in ankylosing spondylitis. Semin Arthritis Rheum. 2005;34(4):668–77.
Lee HS, Kim TH, Yun HR, et al. Radiologic changes of cervical spine in ankylosing spondylitis. Clin Rheumatol. 2001;20(4):262–6.
Lukasiewicz AM, Bohl DD, Varthi AG, et al. Spinal fracture in patients with ankylosing spondylitis: cohort definition, distribution of injuries, and hospital outcomes. Spine (Phila Pa 1976). 2016;41(3):191–6.
Chaudhary SB, Hullinger H, Vives MJ. Management of acute spinal fractures in ankylosing spondylitis. ISRN Rheumatol. 2011;2011:150484.
Werner BC, Samartzis D, Shen FH. Spinal fractures in patients with ankylosing spondylitis: etiology, diagnosis, and management. J Am Acad Orthop Surg. 2016;24(4):241–9.
Westerveld LA, Verlaan JJ, Oner FC. Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J. 2009;18(2):145–56.
Kurucan E, Bernstein DN, Mesfin A. Surgical management of spinal fractures in ankylosing spondylitis. J Spine Surg. 2018;4(3):501–8.
Vonhoff CR, Scandrett K, Al-Khawaja D. Minor trauma in ankylosing spondylitis causing combined cervical spine fracture and esophageal injury. World Neurosurg. 2018;119:151–4.
Kanter AS, Wang MY, Mummaneni PV. A treatment algorithm for the management of cervical spine fractures and deformity in patients with ankylosing spondylitis. Neurosurg Focus. 2008;24(1):E11.
Lazennec JY, d'Astorg H, Rousseau MA. Cervical spine surgery in ankylosing spondylitis: review and current concept. Orthop Traumatol Surg Res. 2015;101(4):507–13.
Hoh DJ, Khoueir P, Wang MY. Management of cervical deformity in ankylosing spondylitis. Neurosurg Focus. 2008;24(1):E9.
Song K, Su X, Zhang Y, et al. Optimal chin-brow vertical angle for sagittal visual fields in ankylosing spondylitis kyphosis. Eur Spine J. 2016;25(8):2596–604.
Mason C, Cozen L, Adelstein L. Surgical correction of flexion deformity of the cervical spine. Calif Med. 1953;79(3):244–6.
Urist MR. Osteotomy of the cervical spine; report of a case of ankylosing rheumatoid spondylitis. J Bone Joint Surg Am. 1958;40-A(4):833–43.
Maciejczak A, Wolan-Nieroda A, Guzik A. C7 extension crosswise osteotomy: a novel osteotomy for correction of chin-on-chest deformity in a patient with ankylosing spondylitis. J Neurosurg Spine. 2020:1–6.
Barsa P, Frohlich R, Adamik J, Suchomel P. Surgical treatment of cervical spine fractures in ankylosing spondylitis patients: posterior stabilization using intraoperative CT scanner-based navigation. Rozhl Chir. 2020;99(5):212–8.
Chevalier X. Intraarticular treatments for osteoarthritis: new perspectives. Curr Drug Targets. 2010;11(5):546–60.
Meka RR, Venkatesha SH, Moudgil KD. Peptide-directed liposomal delivery improves the therapeutic index of an immunomodulatory cytokine in controlling autoimmune arthritis. J Control Release. 2018;286:279–88.
Tuncay M, Calis S, Kas HS, Ercan MT, Peksoy I, Hincal AA. Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation. Int J Pharm. 2000;195(1–2):179–88.
Davis SM, Reichel D, Bae Y, Pennypacker KR. Leukemia inhibitory factor-loaded nanoparticles with enhanced cytokine metabolic stability and anti-inflammatory activity. Pharm Res. 2018;35(1):6.
Lee S, Eun Y, Kim H, Cha HS, Koh EM, Lee J. Machine learning to predict early TNF inhibitor users in patients with ankylosing spondylitis. Sci Rep. 2020;10(1):20299.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Ku, J., Ku, J., Chen, CY., Chang, HK., Wu, JC. (2023). Cervical Spine Disease in Elderly Patients with Ankylosing Spondylitis. In: Fu, KM.G., Wang, M.Y., Virk, M.S., Dimar II, J.R., Mummaneni, P.V. (eds) Treatment of Spine Disease in the Elderly. Springer, Cham. https://doi.org/10.1007/978-3-031-12612-3_12
Download citation
DOI: https://doi.org/10.1007/978-3-031-12612-3_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-12611-6
Online ISBN: 978-3-031-12612-3
eBook Packages: MedicineMedicine (R0)