Abstract
The management of advanced gynecological malignancies is now in the domain of a multidisciplinary evaluation where Interventional Radiology (IR) occupies a prominent role.
IR utilizes minimally invasive advanced image-guided percutaneous techniques in gynecologic treatment, including biopsies, fluid aspiration, drainage catheter placement, and pelvic arterial embolization.
Patients with refractory malignant ascites, pleural effusion, postoperative fluid collections (abscess, seroma, or lymphocele), or with urinary and biliary tracts infiltrations may benefit from percutaneous aspiration of fluid collections or placement of drainage catheters; those with uncontrolled postoperative or oncological advanced mass bleeding can be effectively managed with transpelvic arterial embolization, both in the acute and chronic setting.
Regarding hemorrhagic complications, these may occur in the tumor itself due to cancer tissue erosion and vessels infiltration or may be related to iatrogenic vascular lesions consequent to surgery, mini-invasive procedures, and chemo-radiotherapy; embolization represents a bail-out treatment in both acute and chronic scenarios.
The purpose of this chapter is to review IR procedures in patients affected by gynecological malignancies in advanced stages.
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References
Chow DS, Itagaki MW. Interventional oncology research in the United States: slowing growth, limited focus, and a low level of funding. Radiology. 2010;257:410–7. https://doi.org/10.1148/radiol.10100070.
Mahnken AH, Bruners P, GĂ¼nther RW. Techniques of interventional tumor therapy. Dtsch Arztebl Int. 2008;105:646–53. https://doi.org/10.3238/arztebl.2008.0646.
Cannistra SA. Cancer of the ovary. N Engl J Med. 2004;351(24):2519–29.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.
Benedet JL, Bender H, Jones H III, et al. FIGO Committee on Gynecologic Oncology. FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. Int J Gynaecol Obstet. 2000;70(2):209–62.
Morgan RJ Jr, Copeland L, Gershenson D, et al. The National Comprehensive Cancer Network. NCCN ovarian cancer practice guidelines. Oncology (Williston Park). 1996;10(11, Suppl):293–310.
NNA H, Krapcho M, Garshell J, et al., editors. SEER cancer statistics review, 1975–2010. Bethesda, MD: National Cancer Institute; 2013. Based on November 2012 SEER data submission, posted to the SEER Website: http://seer.cancer.gov/csr/1975_2010/.
Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189(1):12–9.
Scheurer ME, Tortolero-Luna G, Adler-Storthz K. Human papillomavirus infection: biology, epidemiology, and prevention. Int J Gynecol Cancer. 2005;15(5):727–46.
Corr BR, Behbakht K, Spillman MA. Gynecologic biopsy for molecular profiling: a review for the interventional radiologist. Semin Intervent Radiol. 2013;30(4):417–24. https://doi.org/10.1055/s-0033-1359738.
O’Neill SB, O’Connor OJ, Ryan MF, et al. Interventional radiology and the care of the oncology patient. Radiol Res Pract. 2011;2011:160867. https://doi.org/10.1155/2011/160867.
Revel-Mouroz P, Mokrane FZ, Collot S, et al. Hemostatic embolization in oncology. Diagn Interv Imaging. 2015;96:807–21. https://doi.org/10.1016/j.diii.2015.06.008.
Yu H, Stavas JM. The role of interventional radiology in the management of benign and malignant gynecologic diseases. Obstet Gynecol Surv. 2013;68:691–701. https://doi.org/10.1097/OGX.0b013e3182a878c6.
Singh H. Interventional radiology in the gynecological oncology patient. Best Pract Res Clin Obstet Gynaecol. 2001;15:279–90. https://doi.org/10.1053/beog.2000.0168.
Mahnken AH, Bruners P. GĂ¼nther RW: techniques of interventional tumor therapy. Deutsches Arzteblatt. 2008;105(38):646–53.
Yu H, Stavas JM. The role of interventional radiology in the management of benign and malignant gynecologic diseases. Obstet Gynecol Surv Oct. 2013;68(10):691–701. https://doi.org/10.1097/OGX.0b013e3182a878c6.
Stokes LS. Percutaneous management of malignant fluid collections. Semin Interv Radiol. 2007;24:398–408.
Singh H. Interventional radiology in the gynaecological oncology patient. Best Pract Res Clin Obstet Gynaecol. 2001;15(2):279–90. https://doi.org/10.1053/beog.2000.0168.
Fagotti A, Costantini B, Fanfani F, et al. Risk of postoperative pelvic abscess in major gynecologic oncology surgery: one-year single-institution experience. Ann Surg Oncol. 2010;17:2452–8.
Ayantunde AA, Parsons SL. Pattern and prognostic factors in patients with malignant ascites: a retrospective study. Ann Oncol. 2007;18:945–9.
Lee CW, Bociek G, Faught W. A survey of practice in the management of malignant ascites. J Pain Symptom Manage. 1998;16:96–101.
Runyon BA. Care of patients with ascites. N Engl J Med. 1994;330:337–42.
Parsons SL, Watson SA, Steele RJ. Malignant ascites. Br J Surg. 1996;83:6–14.
Mahrer A, Ramchandani P, Trerotola SO, et al. Sclerotherapy in the management of postoperative lymphocele. J Vasc Interv Radiol. 2010;21:1050–3.
Todokoro T, Furniss D, Oda K, et al. Effective treatment of pelvic lymphocele by lymphaticovenular anastomosis. Gynecol Oncol. 2013;128:209–14.
Campbell JJ, Gervais DA. Percutaneous drainage of abscesses in the abdomen and pelvis. In: Mauro MA, KPJ M, Thomson KR, et al., editors. Image-guided interventions. Philadelphia: Saunders Elsevier; 2008. p. 1321–32.
O’Connor OJ, Buckley JM, Maher MM. Interventional radiology in oncology. Cancer Treat Res. 2008;143:493–511.
Uzbek MH, Almeida FA, Sarkis MG, et al. Management of malignant pleural Effusions. Adv Ther. 2010;27(6):334–47.
Seaton KG, Patz EF, Goodman PC. Palliative treatment of malignant pleural effusions: value of smallbore catheter thoracostomy and doxycycline sclerotherapy. Am J Roentgenol. 1995;164(3):589–91.
Lombardi G, Zustovich F, Nicoletto MO, Donach M, Artioli G, Pastorelli D. Diagnosis and treatment of malignant pleural effusion: a systematic literature review and new approaches. Am J Clin Oncol. 2010;33(4):420–3.
Mironov O, Ishill NM, Mironov S, et al. Pleural effusion detected at CT prior to primary cytoreduction for stage III or IV ovarian carcinoma: effect on survival. Radiology. 2011;258:776–84.
Pollak JS, Burdge CM, Rosenblatt M, et al. Treatment of malignant pleural effusions with tunneled long-term drainage catheters. J Vasc Interv Radiol. 2001;12:201–8.
Pollak JS. Malignant pleural effusions: treatment with tunneled long-term drainage catheters. Curr Opin Pulm Med. 2002;8:302–7.
Whitworth JM, Schneider KE, Fauci JM, et al. Outcomes of patients with gynecologic malignancies undergoing video-assisted thoracoscopic surgery (VATS) and pleurodesis for malignant pleural effusion. Gynecol Oncol. 2012;125:646–8.
Russo P. Urologic emergencies in the cancer patient. Semin Oncol. 2000;27(3):284–98.
Park BK, Kim SH, Moon MH. Nonvascular interventions of the urinary tract. J Korean Med Sci. 2002;17(6):727–36.
Kim SH, Park JH, Han MC. Antegrade balloon dilatation and ureteral stenting for the benign ureteral strictures. J Korean Radiol Soc. 1994;30:57–63.
McAleer SJ, Loughlin KR. Nephrolithiasis and pregnancy. Curr Opin Urol. 2004;14(2):123–7.
Dyer RB, Regan JD, Kavanagh PV, Khatod EG, Chen MY, Zagoria RJ. Percutaneous nephrostomy with extensions of the technique: step by step. Radiographics. 2002;22(3):503–25.
Kalogeropoulou C, Kallidonis P, Liatsikos EN. Imaging in percutaneous nephrolithotomy. J Endourol. 2009;23(10):1571–7.
Wong LM, Cleeve LK, Milner AD, Pitman AG. Malignant ureteral obstruction: outcomes after intervention. Have things changed? J Urol. 2007;178(1):178–83.
Harrington KJ, Pandha HS, Kelly SA, et al. Palliation of obstructive nephropathy due to malignancy. Br J Urol. 1995;76:101–7.
Fallon B, Olney L, Culp DA. Nephrostomy in cancer patients: to do or not to do? Br J Urol. 1980;52:237–42.
Shekarriz B, Shekarriz H, Upadhyay J, et al. Outcome of palliative urinary diversion in the treatment of advanced malignancies. Cancer. 1999;85:998–1003.
Rossi P, Bezzi M, Rossi M, et al. Metallic stents in malignant biliary obstruction: results of a multicenter European study of 240 patients. J Vasc Interv Radiol. 1994;5(2):279–85.
Becker CD, Glättli A, Maibach R, Baer HU. Percutaneous palliation of malignant obstructive jaundice with the Wallstent endoprosthesis: follow-up and reintervention in patients with hilar and non-hilar obstruction. J Vasc Interv Radiol. 1993;4(5):597–604.
Carrasco CH, Zornoza J, Bechtel WJ. Malignant biliary obstruction: complications of percutaneous biliary drainage. Radiology. 1984;152(2):343–6.
Nomura T, Shirai Y, Hatakeyama K. Bacteribilia and cholangitis after percutaneous transhepatic biliary drainage for malignant biliary obstruction. Dig Dis Sci. 1999;44(3):542–6.
Nichols DA, MacCarty R, Gaffey TA. Cholangiographic evaluation of bile duct carcinoma. Am J Roentgenol. 1983;141(6):1291–4.
O’Neill MJ, Rafferty EA, Lee SI, et al. Transvaginal interventional procedures: aspiration, biopsy, and catheter drainage. Radiographics. 2001;21(3):657–72. https://doi.org/10.1148/radiographics.21.3.g01ma20657.
Weston M, Soyer P, Barral M, et al. Role of interventional procedures in obstetrics and gynecology. Radiol Clin N Am. 2020;58(2):445–62. https://doi.org/10.1016/j.rcl.2019.11.006.
Gupta S, Wallace MJ, Cardella JF, et al. Quality improvement guidelines for percutaneous needle biopsy. J Vasc Interv Radiol. 2010;21(7):969–75.
Thabet A, Somarouthu B, Oliva E, et al. Image-guided ovarian mass biopsy: efficacy and safety. J Vasc Interv Radiol. 2014;25(12):1922–1927.e1. https://doi.org/10.1016/j.jvir.2014.08.009.
Varadhachary GR, Abbruzzese JL, Lenzi R. Diagnostic strategies for unknown primary cancer. Cancer. 2004;100(9):1776–85.
Spencer JA, Swift SE, Wilkinson N, et al. Peritoneal carcinomatosis: image-guided peritoneal core biopsy for tumor type and patient care. Radiology. 2001;221(1):173–7.
Zikan M, Fischerova D, Pinkavova I, et al. Ultrasound-guided true-cut biopsy of abdominal and pelvic tumors in gynecology. Ultrasound Obstet Gynecol. 2010;36(6):767–72. https://doi.org/10.1002/uog.8803.
Griffin N, Grant LA, Freeman SJ, et al. Image-guided biopsy in patients with suspected ovarian carcinoma: a safe and effective technique? Eur Radiol. 2009;19:230–5.
Kobal B, Noventa M, Cvjeticanin B, et al. Primary debulking surgery versus primary neoadjuvant chemotherapy for high grade advanced-stage ovarian cancer: comparison of survivals. Radiol Oncol. 2018;52(3):307–19.
Van der Burg ME, van Lent M, Buyse M, et al. The effect of debulking surgery after induction chemotherapy on the prognosis in advanced epithelial ovarian cancer: gynecological cancer cooperative Group of the European Organization for research and treatment of cancer. N Engl J Med. 1995;332:629–34.
Rose PG, Nerenstone S, Brady MF, et al. Secondary surgical cytoreduction for advanced ovarian carcinoma. N Engl J Med. 2004;351:2489–97.
Hewitt M, Anderson K, Hall G, et al. Women with peritoneal carcinomatosis of unknown origin: efficacy of image-guided biopsy to determine site-specific diagnosis. BLOG. 2006;114(1):46–50.
Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol. 2011;5(1):5–23.
Walkey MM, Freidman AC, Sohotra AC, et al. CT manifestations of peritoneal carcinomatosis. AJR Am J Roentgenol. 1988;150:1035–41.
Malmstrom H. Fine-needle aspiration cytology versus core biopsies in the evaluation of recurrent gynecologic malignancies. Gynecol Oncol. 1997;65:69–73.
Karoo RO, Lloyd TD, Garcea G, et al. How valuable is ascitic cytology in the detection and management of malignancy? Postgrad Med J. 2003;79:292–4.
Oge T, Yalcin OT, Ozalp SS, et al. Sonographically guided core biopsy: a minimally invasive procedure for managing adnexal masses. J Ultrasound Med. 2013;32(11):2023–7. https://doi.org/10.7863/ultra.32.11.2023.
Yarram SG, Nghiem HV, Higgins E, et al. Evaluation of imaging-guided core biopsy of pelvic masses. AJR Am J Roentgenol. 2007;188(5):1208–11. https://doi.org/10.2214/AJR.05.1393.
Arellano RS, Maher M, Gervais DA, et al. The difficult biopsy: let’s make it easier. Curr Probl Diagn Radiol. 2003;32(5):218–26.
Chojniak R, Isberner RK, Viana LM, et al. Computed tomography-guided needle biopsy: experience from 1,300 procedures. Sao Paulo Med J. 2006;124:10–4.
Bdour M, Hourani S, Mefleh W, et al. Comparison between fine-needle aspiration cytology and true-cut biopsy in the diagnosis of breast cancer. J Surg Pak (Int). 2008;13:19–21.
Charboneau JW, Reading CC, Welch TJ. CT and sonographically guided needle biopsy: current techniques and new innovations. AJR. 1990;154:1–1.
Scanlan KA, Propeck PA, Lee FT Jr. Invasive procedures in the female pelvis: the value of transabdominal, endovaginal, and endorectal US guidance. Radiographics. 2001;21:491–506.
Dodd GD III, Esola CC, Memel DS, et al. Sonography: the undiscovered jewel of interventional radiology. Radiographics. 1996;16:1271–88.
Memel DS, Dodd GD III, Esola CC. Efficacy of sonography as a guidance technique for biopsy of abdominal, pelvic, and retroperitoneal lymph nodes. AJR. 1996;167:957–62.
Bret PM, Guibaud L, Atri M, et al. Transvaginal US-guided aspiration of ovarian cysts and pelvic masses. Radiology. 1992;185:377–80.
Gupta S, Nguyen HL, Morello FA Jr, et al. Various approaches for CT- guided percutaneous biopsy of deep pelvic lesions: anatomic and technical considerations. Radiographics. 2004;24:175–89.
Gupta S, Madoff DC, Ahrar K, et al. CT-guided needle biopsy of deep pelvic lesions by extraperitoneal approach through iliopsoas muscle. Cardiovasc Intervent Radiol. 2003;26(6):534–8. https://doi.org/10.1007/s00270-003-0035-8.
Havrilesky LJ, Krivak TC, Mucenski JW, et al. Impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer. Am J Obstet Gynecol. 2010;203(2):e1–7.
Bree RL, Goldstein HM, Wallace S. Transcatheter embolization of the internal iliac artery in the management of neoplasms of the pelvis. Surg Gynecol Obstet. 1976;143:597–601.
Grace DM, Pitt DF, Gold RE. Vascular embolization and occlusion by angiographic techniques as an aid or alternative to operation. Surg Gynecol Obstet. 1976;143:469–82.
Hendrickx P, Orth G, Grunert J. Embolisation of pelvic bleeding lesions from benign origin—long-term results. J Belg Radiol. 1995;78:339–41.
Hutchins FL Jr, Worthington-Kirsch R. Embolotherapy for myoma-induced menorrhagia. Obstet Gynecol Clin North Am. 2000;27:397. https://doi.org/10.1016/s0889-8545(00)80030-3.
Baakdah H, Tulandi T. Uterine fibroid embolization. Clin Obstet Gynecol. 2005;48:361–8. https://doi.org/10.1097/01.grf.0000159542.19598.ea.
Li X, Wang Z, Chen J, et al. Uterine artery embolization for the management of secondary postpartum haemorrhage associated with placenta accreta. Clin Radiol. 2012;67:e71–6. https://doi.org/10.1016/j.crad.2012.07.021.
Hori A. Complications following transcatheter arterial embolization for haemorrhage associated with pelvic fracture. Nihon Igaku Hoshasen Gakkai Zasshi. 1991;51:365–74.
Mihmanli I, Cantasdemir M, Kantarci F, et al. Percutaneous embolization in the management of intractable vaginal bleeding. Arch Gynecol Obstet. 2001;264:211–4. https://doi.org/10.1007/s004040000119.
Tinelli A, Prudenzano R, Malvasi A, et al. Emergency endovascular nanopharmacologic treatment in advanced gynecological cancers. Int J Gynecol Cancer. 2010;20:1250–5. https://doi.org/10.1111/IGC.0b013e3181e4a68d.
Albu S, Grigoriu C, Vasiliu C, et al. The role of uterine artery embolization in cervical cancer—single case report. Medica (Buchar). 2011;6:137–40.
Cabrera R, Nelson DR. Review article: the management of hepatocellular carcinoma. Aliment Pharmacol Ther. 2010;31:461–76. https://doi.org/10.1111/j.1365-2036.2009.04200.x.
Amesur NB, Zajko AB, Carr BI. Chemo-embolization for unresectable hepatocellular carcinoma with different sizes of embolization particles. Dig Dis Sci. 2008;53:1400–4. https://doi.org/10.1007/s10620-007-9995-x.
RodrĂguez Carvajal R, Orgaz A, Leal JI, et al. Renal embolization and nephrectomy in a single surgical act in high-risk renal tumor pathology. Ann Vasc Surg. 2011;25:222–8. https://doi.org/10.1016/j.avsg.2010.03.037.
Spinosa DJ, Angle JF, McGraw JK, et al. Transcatheter treatment of life-threatening lower gastrointestinal bleeding due to advanced pelvic malignancy. Cardiovasc Intervent Radiol. 1998;21:503–5. https://doi.org/10.1007/s002709900312.
Matsumoto AH, Selby JB Jr, Tegtmeyer CJ. Detachable balloons as peripheral vascular embolic agents. Semin Intervent Radiol. 1992;9:62–71. https://doi.org/10.1055/s-2008-1074671.
Marin ML, Veith FJ, Panetta TF, et al. Percutaneous transfemoral insertion of a stented graft to repair a traumatic femoral arteriovenous fistula. J Vasc Surg. 1993;18:299–302.
Piazza F, Corvino F, Silvestre M, et al. Role of interventional radiology in obstetric and gynecological diseases. J Radiol Rev. 2020;7:26–38. https://doi.org/10.23736/S2283-8376.20.00253-3.
Corvino F, Giurazza F, Cangiano G, et al. Endovascular treatment of peripheral vascular blowout syndrome in end-stage malignancies. Ann Vasc Surg. 2019;58:382.e1–5. https://doi.org/10.1016/j.avsg.2018.10.051.
Coppola M, Giurazza F, Corvino F, et al. Severe metrorrhagia in patients with advanced gynecologic cancer: endovascular treatment benefits in acute and chronic setting. Radiol Med. 2021;126(2):277–82. https://doi.org/10.1007/s11547-020-01251-6.
Patanè D, Coniglio G, Bonomo S, Camerano F, Arcerito F, Calcara G, Bisceglie P, Malfa P. Gynecological malignancies: bail-out interventional radiology treatments. Semin Ultrasound CT MR. 2021;42(1):95–103. https://doi.org/10.1053/j.sult.2020.09.003.
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Patanè, D. et al. (2023). Malignancies: Collections Drainage, Biopsies, and Endovascular Bail-Out Treatments. In: Niola, R., Pinto, A., Giurazza, F. (eds) Diagnostic and Interventional Radiology in Gynecological and Obstetric Diseases. Springer, Cham. https://doi.org/10.1007/978-3-031-11910-1_13
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