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Challenges in fMRI and Its Limitations

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Functional Neuroradiology

Abstract

This chapter explores some of the challenges of functional magnetic resonance imaging (fMRI); in particular, the constraints encountered in terms of spatial and temporal resolution and the factors that limit the ability of MRI to detect functional activation. In addition to examining the factors limiting the sensitivity and resolution of fMRI, this chapter also explores some of the trade-offs involved in optimizing one or more of these variables. As fMRI experiments are performed in higher fields, the limits of temporal and spatial resolution continue to be pushed.

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Acknowledgments

NIH NS38467, NS40497, EB00473.

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  1. Department of Diagnostic Radiology and Biomedical Imaging, Biomedical Engineering, and Neurosurgery, Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA

    R. Todd Constable

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Correspondence to R. Todd Constable .

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Editors and Affiliations

  1. Division of Neuroradiology, Thomas Jefferson University, Philadelphia, PA, USA

    Scott H. Faro

  2. Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA

    Feroze B. Mohamed

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Constable, R.T. (2023). Challenges in fMRI and Its Limitations. In: Faro, S.H., Mohamed, F.B. (eds) Functional Neuroradiology. Springer, Cham. https://doi.org/10.1007/978-3-031-10909-6_22

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