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Deuterium Oxide and Deuteration in Biosciences

  • Book
  • © 2022

Overview

Authors:
  1. Chang-Hwei Chen

    1. Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, Albany, USA

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  • Provides comprehensive coverage on the fundamentals and implications of deuterium oxide and deuteration research

  • Supports coursework in the areas of biochemistry, biophysics, biomedical sciences and pharmacology

  • Addresses the applications of deuterium oxide to investigate biochemical reactions and health-related research

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Roles of Regular and Heavy Water in Biosciences

    1. Front Matter

      Pages 1-1
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    2. Overview: Background and Applications

      • Chang-Hwei Chen
      Pages 3-14

    3. Characteristics of Deuterium Oxide Versus Hydrogen Oxide

      • Chang-Hwei Chen
      Pages 15-25

  3. Molecular Interactions of Deuterium Versus Hydrogen Oxide

    1. Front Matter

      Pages 27-27
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    2. Deuterium Bonding Versus Hydrogen Bonding

      • Chang-Hwei Chen
      Pages 29-42

    3. Hydrophobic Interaction in D2O Versus H2O

      • Chang-Hwei Chen
      Pages 43-55

  4. Implications of Deuterium Oxide and Deuteration in Biological Systems

    1. Front Matter

      Pages 57-57
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    2. Deuterium Oxide and Deuteration Effects on Biomolecules

      • Chang-Hwei Chen
      Pages 59-71

    3. Effects of D2O and Deuteration on Biomembranes

      • Chang-Hwei Chen
      Pages 73-84

  5. Applications of D2O and Deuteration to Biochemical Reactions

    1. Front Matter

      Pages 85-85
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    2. Biochemical Effects of Deuterium Oxide and Deuteration

      • Chang-Hwei Chen
      Pages 87-100

    3. Physical Methods for Investigating D2O and Deuteration Effects

      • Chang-Hwei Chen
      Pages 101-117

  6. Exploration of Deuterium Oxide and Deuteration in Health-Related Research

    1. Front Matter

      Pages 119-119
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    2. Living Cells Grown in Deuterium Oxide for Deuteration

      • Chang-Hwei Chen
      Pages 121-133

    3. Deuterium Oxide and Deuteration Effects on Health Issues

      • Chang-Hwei Chen
      Pages 135-147

  7. Applications of Deuterium Oxide and Deuteration to Pharmacology

    1. Front Matter

      Pages 149-149
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    2. Deuterium Oxide Effects on Thermostability of Vaccines

      • Chang-Hwei Chen
      Pages 151-161

    3. Deuterium Oxide and Deuteration Effects on Pharmacology

      • Chang-Hwei Chen
      Pages 163-177

  8. Back Matter

    Pages 179-181
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Keywords

About this book

This new book provides comprehensive coverage of the subjects of deuterium oxide and deuteration in biosciences, with an emphasis on the biochemical, biomedical, and pharmacological aspects. Deuterium oxide and deuteration effects also offer various implications for health-related issues, including diseases, vaccines and drugs. Organized in six sections, the chapter topics include the role of regular and heavy water in biosciences, and their implications to biomolecules, biochemical processes, health-related research, and pharmacology.

Due to the broad scope, the book may be used as a supplemental text for upper-level undergraduate and graduate courses in the related fields of biochemistry, biology, biomedical sciences, biophysics, and pharmacology. Researchers and pharmaceutical industry professionals will also find the content useful in order to gain knowledge and better understand the implications of deuterium oxide and deuteration research.

Authors and Affiliations

  • Institute for Health and the Environment and Department of Biomedical Sciences, University at Albany, State University of New York, Albany, USA

    Chang-Hwei Chen

About the author

Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany.

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