Overview
- Describes in detail the connection between CSD and mitochondrial function
- Synthesizes our knowledge and understanding of CSD
- Provides real-time physiological mapping of brain funcitons in vivo
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Table of contents (10 chapters)
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Front Matter
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Back Matter
Keywords
- Cortical Spreading Depression
- Brain Energy Metabolism
- Mitochondrial Function in vivo
- Microcirculation and cellular oxygenation
- Brain Ionic Homeostasis
- Patients monitoring
- brain pathophysiology
- Leao’ Cortical Spreading Depression
- LifenLight Score
- Anoxia and Hypoxia
- Hyperbaric Hyperoxia
- traumatic Brain Injury
- effects of pharmacological Agents
- Brain injuries
About this book
This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions.
This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.
Authors and Affiliations
About the authors
Dr. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel.
Dr Avraham Mayevsky's field of research since they started their Post-Doc training with Prof. Britton Chance in 1972, was Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity they were able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable them to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications. During the years Dr Mayevsky's laboratory published more than 60 papers dealing with the subject of Cortical Spreading Depression of Leao (CSD).
Dr. Judith Sonn was a part of the Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel, for 45 years and retired in 2017.
After graduation, Dr Judith Sonn was a laboratory Manager in Prof. Joseph Kedem’s laboratory, which investigated the physiology of the cardiovascular system. She continued to study for the master’s degree under the supervision of Professor Kedem. The M.Sc. thesis (1979, Summa Cum Laude) was "Oxygen Balance in the Myocardium". This research approach helped to evaluate the myocardial oxygen balance In-Vivo which was described in about 15 articles.
In 1991 Dr Judith Sonn joined Professor Avraham Mayevsky’s research team and as a Ph.D. student under his Supervision. The Doctoral dissertation (1996) was “Effect of Spreading Depression on the Interrelation Between Brain Energy Metabolism and Ion Homeostasis In-Vivo”. During that time, they published 28 articles on the CSD subject.
Bibliographic Information
Book Title: Cortical Spreading Depression of Leao
Book Subtitle: From Mitochondrial Function to Brain Metabolic Score (BMS)
Authors: Avraham Mayevsky, Judith Sonn
DOI: https://doi.org/10.1007/978-3-031-08068-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-031-08067-8Published: 20 October 2022
Softcover ISBN: 978-3-031-08070-8Published: 21 October 2023
eBook ISBN: 978-3-031-08068-5Published: 19 October 2022
Edition Number: 1
Number of Pages: XXI, 420
Number of Illustrations: 184 b/w illustrations, 58 illustrations in colour
Topics: Neurosciences, Biological and Medical Physics, Biophysics, Biomedical Engineering and Bioengineering, Neurochemistry, Clinical Psychology