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Primary Hypertension in Children

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Pediatric Hypertension

Abstract

Hypertension in children is not as common as in adults, and its prevalence in the pediatric population is about 3–4%. Primary hypertension is more common as compared to secondary hypertension, particularly in adolescents. Many of the risk factors for primary hypertension are well-known, and the ones that are modifiable include obesity, excessive sodium intake, inadequate physical activity, and obstructive sleep apnea. Studies on the pathophysiology of primary hypertension in children are limited. However, evidence indicates that a combination of genetic, environmental, and biological interactions, as seen in the development of hypertension in adults, provide a basis to understand hypertension in children as well. Tracking studies have established that adult primary hypertension has its antecedents during childhood. Primary hypertension is a diagnosis of exclusion, and a thorough clinical evaluation is necessary to rule out any underlying cause for secondary hypertension. Early diagnosis and management of increased BP in the pediatric population is necessary to decrease the risks for end-organ injury and adult-onset cardiovascular disease.

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References

  • Archbold KH, Vasquez MM, Goodwin JL, Quan SF (2012) Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: report from the Tucson Children’s Assessment of Sleep Apnea Study. J Pediatr 161(1):26–30

    Article  Google Scholar 

  • Ayer JG, Harmer JA, Nakhla S, Xuan W, Ng MK, Raitakari OT, Marks GB, Celermajer DS (2009) HDL-cholesterol, BP, and asymmetric dimethylarginine are significantly associated with arterial wall thickness in children. Arterioscler Thromb Vasc Biol 29(6):943–949. https://doi.org/10.1161/ATVBAHA.109.184184

    Article  CAS  Google Scholar 

  • Baker-Smith CM, Pietris N, Jinadu L (2020) Recommendations for exercise and screening for safe athletic participation in hypertensive youth. Pediatr Nephrol 35:743–752. https://doi.org/10.1007/s00467-019-04258-y

    Article  Google Scholar 

  • Baracco R, Kapur G, Mattoo T, Jain A, Valentini R, Ahmed M, Thomas R (2012) Prediction of primary vs secondary hypertension in children. J Clin Hypertens (Greenwich) 14(5):316–321. https://doi.org/10.1111/j.1751-7176.2012.00603.x

    Article  Google Scholar 

  • Barnoya J, Glantz SA (2005) Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation 111(20):2684–2698. https://doi.org/10.1161/CIRCULATIONAHA.104.492215

    Article  Google Scholar 

  • Berenson GS, Mcmann CA, Voors AW (1980) Cardiovascular risk factors in children: the early natural history of atherosclerosis and essential hypertension. Oxford University Press, New York

    Google Scholar 

  • Berenson GS, Chen W, Dasmahapatra P, Fernandez C, Giles T, Xu J, Srinivasan SR (2011) Stimulus response of BP in black and white young individuals helps explain racial divergence in adult cardiovascular disease: the Bogalusa Heart Study. J Am Soc Hypertens 5(4):230–238. https://doi.org/10.1016/j.jash.2011.02.006

    Article  Google Scholar 

  • Boyd GS, Koenigsberg J, Falkner B, Gidding S, Hassink S (2005) Effect of obesity and high BP on plasma lipid levels in children and adolescents. Pediatrics 116(2):442–446

    Article  Google Scholar 

  • Bradley TD, Floras JS (2009) Obstructive sleep apnoea and its cardiovascular consequences. Lancet 373:82

    Article  Google Scholar 

  • Brady TM, Solomon BS, Neu AM, Siberry GK, Parekh RS (2010) Patient-, provider-, and clinic-level predictors of unrecognized elevated BP in children. Pediatrics 125(6):e1286–e1293. https://doi.org/10.1542/peds.2009-0555

    Article  Google Scholar 

  • Bucher BS, Ferrarini A, Weber N, Bullo M, Bianchetti MG, Simonetti GD (2013) Primary hypertension in childhood. Curr Hypertens Rep 15(5):444–452. https://doi.org/10.1007/s11906-013-0378-8

    Article  CAS  Google Scholar 

  • Bunnell RE, Agaku IT, Arrazola RA, Apelberg BJ, Caraballo RS, Corey CG, Coleman BN, Dube SR, King BA (2015) Intentions to smoke cigarettes among never-smoking US middle and high school electronic cigarette users: National Youth Tobacco Survey, 2011–2013. Nicotine Tob Res 17(2):228–235. https://doi.org/10.1093/ntr/ntu166

    Article  Google Scholar 

  • Cao Y, Zhu L, Liu J (2021) Effects of aerobic exercise on obese children with metabolic syndrome: a systematic review and meta-analysis. J Pediatr Endocrinol Metab. https://doi.org/10.1515/jpem-2021-0295. Epub ahead of print. PMID: 34293838

  • Carrico RJ, Sun SS, Sima AP, Rosner B (2013) The predictive value of childhood BP values for adult elevated BP. Open J Pediatr 3(2):116–126. https://doi.org/10.4236/ojped.2013.32022. PMID: 23991354; PMCID: PMC3752649. https://doi.org/10.1161/CIRCULATIONAHA.107.730366

    Article  Google Scholar 

  • Cheung EL, Bell CS, Samuel JP, Poffenbarger T, Redwine KM, Samuels JA (2017) Race and obesity in adolescent hypertension. Pediatrics 139(5):e20161433. https://doi.org/10.1542/peds.2016-1433

    Article  Google Scholar 

  • Chon H, Gaillard CA, van der Meijden BB, Dijstelbloem HM, Kraaijenhagen RJ, van Leenen D, Holstege FC, Joles JA, Bluyssen HA, Koomans HA, Braam B (2004) Broadly altered gene expression in blood leukocytes in essential hypertension is absent during treatment. Hypertension 43(5):947–951. https://doi.org/10.1161/01.HYP.0000123071.35142.72

    Article  CAS  Google Scholar 

  • Cogswell ME, Yuan K, Gunn JP, Gillespie C et al (2014) Vital signs: sodium intake among U.S. school-aged children – 2009–2010. MMWR Morb Mortal Wkly Rep 63:789–797

    Google Scholar 

  • Coke LA, Hayman LL (2021) The impact of structural racism on cardiovascular health. J Cardiovasc Nurs 36(3):196–197. PMID: 33830719

    Article  Google Scholar 

  • Coppo M, Bandinelli M, Berni A, Galastri S, Abbate R, Poggesi L, Marra F, Gensini GF, Boddi M (2011) Ang II upregulation of the T-lymphocyte renin-angiotensin system is amplified by low-grade inflammation in human hypertension. Am J Hypertens 24(6):716–723. https://doi.org/10.1038/ajh.2011.32

    Article  CAS  Google Scholar 

  • Cuffee YL, Hargraves JL, Allison J (2012) Exploring the association between reported discrimination and hypertension among African Americans: a systematic review. Ethn Dis 22(4):422–431. PMID: 23140072

    Google Scholar 

  • Dasgupta K, O’Loughlin J, Chen S, Karp I, Paradis G, Tremblay J, Hamet P, Pilote L (2006) Emergence of sex differences in prevalence of high systolic BP: analysis of a longitudinal adolescent cohort. Circulation 114(24):2663–2670. https://doi.org/10.1161/CIRCULATIONAHA.106.624536

    Article  Google Scholar 

  • de Jong F, Monuteaux MC, van Elburg RM et al (2012) Systematic review and meta-analysis of preterm birth and later systolic blood pressure. Hypertension 59:226

    Article  Google Scholar 

  • Din-Dzietham R, Liu Y, Bielo MV, Shamsa F (2007) High BP trends in children and adolescents in national surveys, 1963 to 2002. Circulation 116(13):1488–1496. https://doi.org/10.1161/CIRCULATIONAHA.106.683243

    Article  Google Scholar 

  • Dolezsar CM, McGrath JJ, Herzig AJM, Miller SB (2014) Perceived racial discrimination and hypertension: a comprehensive systematic review. Health Psychol 33(1):20–34. https://doi.org/10.1037/a0033718. PMID: 24417692; PMCID: PMC5756074

    Article  Google Scholar 

  • Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, Litwin M, Niemirska A, Oguz B, Schmidt BM, Sözeri B, Querfeld U, Melk A, Schaefer F, Wühl E, 4C Study Consortium (2013) Carotid artery intima-media thickness and distensibility in children and adolescents: reference values and role of body dimensions. Hypertension 62(3):550–556. https://doi.org/10.1161/HYPERTENSIONAHA.113.01297. Epub 2013 Jul 1. PMID: 23817494

    Article  CAS  Google Scholar 

  • Ekelund U, Luan J, Sherar LB, Esliger DW, Griew P, Cooper A, International Children’s Accelerometry Database C (2012) Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents. JAMA 307(7):704–712. https://doi.org/10.1001/jama.2012.156

    Article  CAS  Google Scholar 

  • Falkner B, Lurbe E (2021) Primary hypertension beginning in childhood and risk for future cardiovascular disease. J Pediatr. https://doi.org/10.1016/j.jpeds.2021.08.008

  • Farsalinos K, Cibella F, Caponnetto P, Campagna D, Morjaria JB, Battaglia E, Caruso M, Russo C, Polosa R (2016) Effect of continuous smoking reduction and abstinence on BP and heart rate in smokers switching to electronic cigarettes. Intern Emerg Med 11(1):85–94. https://doi.org/10.1007/s11739-015-1361-y

    Article  Google Scholar 

  • Flynn JT (2011) Ambulatory BP monitoring in children: imperfect yet essential. Pediatr Nephrol 26(12):2089–2094. https://doi.org/10.1007/s00467-011-1984-9

    Article  Google Scholar 

  • Flynn JT (2013) The changing face of pediatric hypertension in the era of the childhood obesity epidemic. Pediatr Nephrol 28(7):1059–1066. https://doi.org/10.1007/s00467-012-2344-0

    Article  Google Scholar 

  • Flynn JT, Daniels SR, Hayman LL, Maahs DM, BW MC, Mitsnefes M, Zachariah JP, Urbina EM, American Heart Association Atherosclerosis H, Obesity in Youth Committee of the Council on Cardiovascular Disease in the Y (2014) Update: ambulatory BP monitoring in children and adolescents: a scientific statement from the American Heart Association. Hypertension 63(5):1116–1135. https://doi.org/10.1161/HYP.0000000000000007

    Article  CAS  Google Scholar 

  • Flynn JT, Kaelber DC, Baker-Smith CM et al (2017) Clinical practice guideline for screening and management of High BP in children and adolescents. Pediatrics 140(3):e20171904

    Article  Google Scholar 

  • Friedemann C, Heneghan C, Mahtani K, Thompson M, Perera R, Ward AM (2012) Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis. BMJ 345:e4759. https://doi.org/10.1136/bmj.E4759

    Article  Google Scholar 

  • Gopinath B, Baur LA, Hardy LL, Kifley A, Rose KA, Wong TY, Mitchell P (2012) Relationship between a range of sedentary behaviours and BP during early adolescence. J Hum Hypertens 26(6):350–356. https://doi.org/10.1038/jhh.2011.40

    Article  CAS  Google Scholar 

  • Gupta-Malhotra M, Banker A, Shete S, Hashmi SS, Tyson JE, Barratt MS, Hecht JT, Milewicz DM, Boerwinkle E (2015) Essential hypertension vs. secondary hypertension among children. Am J Hypertens 28(1):73–80. https://doi.org/10.1093/ajh/hpu083. Epub 2014 May 18. PMID: 24842390; PMCID: PMC4318949

    Article  Google Scholar 

  • Halbach SM, Hamman R, Yonekawa K, Hanevold C (2016) Utility of ambulatory BP monitoring in the evaluation of elevated clinic BPs in children. J Am Soc Hypertens 10(5):406–412. https://doi.org/10.1016/j.jash.2016.02.013

    Article  Google Scholar 

  • Halldorsson TI, Gunnarsdottir I, Birgisdottir BE, Gudnason V, Aspelund T, Thorsdottir I (2011) Childhood growth and adult hypertension in a population of high birth weight. Hypertension 58(1):8–15. https://doi.org/10.1161/HYPERTENSIONAHA.111.170985

    Article  CAS  Google Scholar 

  • Hanevold CD (2021) Salt sensitivity of BP in childhood and adolescence. Pediatr Nephrol. https://doi.org/10.1007/s00467-021-05178-6. Epub ahead of print. PMID: 34327584

  • Hanevold CD, Pollock JS, Harshfield GA (2019) Racial differences in microalbumin excretion in healthy adolescents. Hypertension 51(2):334–338. https://doi.org/10.1161/HYPERTENSIONAHA.107.098095

    Article  CAS  Google Scholar 

  • Hanevold CD, Faino AV, Flynn JT (2020) Use of automated office BP measurement in the evaluation of elevated BPs in children and adolescents. J Pediatr 227:204

    Article  Google Scholar 

  • Hardy ST, Sakhuja S, Jaeger BC, Urbina EM, Suglia SF, Feig DI, Muntner P (2021) Trends in BP and hypertension among US children and adolescents, 1999–2018. JAMA Netw Open 4(4):e213917. https://doi.org/10.1001/jamanetworkopen.2021.3917. PMID: 33792732; PMCID: PMC8017470

    Article  Google Scholar 

  • Hovi P, Vohr B, Ment LR, Doyle LW, McGarvey L, Morrison KM, Evensen KA, van der Pal S, Grunau RE, APIC Adults Born Preterm International Collaboration, Brubakk AM, Andersson S, Saigal S, Kajantie E (2016) Blood pressure in young adults born at very low birth weight: adults born preterm international collaboration. Hypertension 68(4):880–887

    Article  CAS  Google Scholar 

  • Jackson SL, Zhang Z, Wiltz JL, Loustalot F, Ritchey MD, Goodman AB, Quanhe Y (2018) Hypertension among youths – United States, 2001–2016. MMWR Morb Mortal Wkly Rep 67:758

    Article  Google Scholar 

  • Jacques-Tiura AJ, Ellis DA, Idalski Carcone A, Naar S, Brogan Hartlieb K, Towner EK, Templin T, Jen KC (2019) African American adolescents’ weight loss skills utilization: effects on weight change in a sequential multiple assignment randomized trial. J Adolesc Health 64(3):355–361. https://doi.org/10.1016/j.jadohealth.2018.09.003. Epub 2018 Nov 2. PMID: 30392864; PMCID: PMC6996585

    Article  Google Scholar 

  • Javaheri S, Storfer-Isser A, Rosen CL, Redline S (2008) Sleep quality and elevated blood pressure in adolescents. Circulation 118(10):1034–1040

    Article  Google Scholar 

  • Jung FF, Ingelfinger JR (1993) Hypertension in childhood and adolescence. Pediatr Rev 14(5):169–179

    Google Scholar 

  • Kapur G (2010) What do I need to know to start ambulatory BP monitoring for children with hypertension? Available http://www2.aap.org/sections/nephrology/NephrologyNewsletterSpring2013.pdf

  • Kapur G, Baracco R (2013) Evaluation of hypertension in children. Curr Hypertens Rep 15(5):433–443. https://doi.org/10.1007/s11906-013-0371-2

    Article  CAS  Google Scholar 

  • Kapur G, Ahmed M, Pan C, Mitsnefes M, Chiang M, Mattoo TK (2010) Secondary hypertension in overweight and stage 1 hypertensive children: a Midwest Pediatric Nephrology Consortium report. J Clin Hypertens (Greenwich) 12(1):34–39. https://doi.org/10.1111/j.1751-7176.2009.00195.x

    Article  Google Scholar 

  • Kelishadi R, Mirmoghtadaee P, Najafi H, Keikha M (2015) Systematic review on the association of abdominal obesity in children and adolescents with cardio-metabolic risk factors. J Res Med Sci 20(3):294–307. PMID: 26109978; PMCID: PMC4468236

    Google Scholar 

  • Khoury M, Khoury P, Bazzano L, Burns TL, Daniels S, Dwyer T, Ikonen J, Jacobs DR Jr, Juonala M, Kähönen M, Prineas R, Raitakari OT, Steinberger J, Venn A, Viikari J, Woo JG, Sinaiko A, Urbina EM (2021) Prevalence implications of the 2017 American Academy of Pediatrics hypertension guideline and associations with adult hypertension. J Pediatr:S0022-3476(21)00959-8

    Google Scholar 

  • Kivimaki M, Lawlor DA, Smith GD, Elovainio M, Jokela M, Keltikangas-Jarvinen L, Vahtera J, Taittonen L, Juonala M, Viikari JS, Raitakari OT (2008) Association of age at menarche with cardiovascular risk factors, vascular structure, and function in adulthood: the Cardiovascular Risk in Young Finns study. Am J Clin Nutr 87(6):1876–1882

    Article  CAS  Google Scholar 

  • Kulaga Z, Litwin M, Tkaczyk M, Palczewska I, Zajaczkowska M, Zwolinska D, Krynicki T, Wasilewska A, Moczulska A, Morawiec-Knysak A, Barwicka K, Grajda A, Gurzkowska B, Napieralska E, Pan H (2011) Polish 2010 growth references for school-aged children and adolescents. Eur J Pediatr 170(5):599–609. https://doi.org/10.1007/s00431-010-1329-x

    Article  Google Scholar 

  • Kuo YL, Kang KT, Chiu SN, Weng WC, Lee PL, Hsu WC (2015) Blood pressure after surgery among obese and nonobese children with obstructive sleep apnea. Otolaryngol Head Neck Surg 152(5):931–940

    Article  Google Scholar 

  • Levy RV, Brathwaite KE, Sarathy H, Reidy K, Kaskel FJ, Melamed ML (2021) Analysis of active and passive tobacco exposures and BP in US children and adolescents. JAMA Netw Open 4(2):e2037936

    Article  Google Scholar 

  • Li AM, Au CT, Ng C, Lam HS, Ho CKW, Wing YK (2014) A 4-year prospective follow-up study of childhood OSA and its association with BP. Chest 145(6):1255–1263

    Article  Google Scholar 

  • Limratchapong C, Nuntnarumit P, Paksi W et al (2021) Current obesity was associated with hypertension in children born very low birth weight. BMC Res Notes 14:196. https://doi.org/10.1186/s13104-021-05611-x

    Article  Google Scholar 

  • Litwin M, Sladowska J, Antoniewicz J, Niemirska A, Wierzbicka A, Daszkowska J, Wawer ZT, Janas R, Grenda R (2007) Metabolic abnormalities, insulin resistance, and metabolic syndrome in children with primary hypertension. Am J Hypertens 20(8):875–882. https://doi.org/10.1016/j.amjhyper.2007.03.005

    Article  CAS  Google Scholar 

  • Litwin M, Michalkiewicz J, Niemirska A, Gackowska L, Kubiszewska I, Wierzbicka A, Wawer ZT, Janas R (2010) Inflammatory activation in children with primary hypertension. Pediatr Nephrol 25(9):1711–1718. https://doi.org/10.1007/s00467-010-1548-4

    Article  Google Scholar 

  • Litwin M, Michalkiewicz J, Gackowska L (2013a) Primary hypertension in children and adolescents is an immuno-metabolic disease with hemodynamic consequences. Curr Hypertens Rep 15(4):331–339. https://doi.org/10.1007/s11906-013-0360-5

    Article  CAS  Google Scholar 

  • Litwin M, Michalkiewicz J, Trojanek J, Niemirska A, Wierzbicka A, Szalecki M (2013b) Altered genes profile of renin-angiotensin system, immune system, and adipokines receptors in leukocytes of children with primary hypertension. Hypertension 61(2):431–436. https://doi.org/10.1161/HYPERTENSIONAHA.111.00181

    Article  CAS  Google Scholar 

  • Lurbe E, Torro I, Alvarez V, Nawrot T, Paya R, Redon J, Staessen JA (2005) Prevalence, persistence, and clinical significance of masked hypertension in youth. Hypertension 45(4):493–498. https://doi.org/10.1161/01.HYP.0000160320.39303.ab

    Article  CAS  Google Scholar 

  • Lurbe E, Torro I, Garcia-Vicent C, Alvarez J, Fernandez-Fornoso JA, Redon J (2012) BP and obesity exert independent influences on pulse wave velocity in youth. Hypertension 60(2):550–555. https://doi.org/10.1161/HYPERTENSIONAHA.112.194746

    Article  CAS  Google Scholar 

  • Lurbe E, Agabiti-Rosei E, Cruickshank JK, Dominiczak A, Erdine S, Hirth A, Invitti C, Litwin M, Mancia G, Pall D, Rascher W, Redon J, Schaefer F, Seeman T, Sinha M, Stabouli S, Webb NJ, Wuhl E, Zanchetti A (2016) 2016 European Society of Hypertension guidelines for the management of high BP in children and adolescents. J Hypertens 34(10):1887–1920. https://doi.org/10.1097/HJH.0000000000001039

    Article  CAS  Google Scholar 

  • Lurbe E, Torró I, Álvarez J, Aguilar F, Mancia G, Redon J, Redon P (2019) Impact of ESH and AAP hypertension guidelines for children and adolescents on office and ambulatory BP-based classifications. J Hypertens 37(12):2414–2421

    Article  CAS  Google Scholar 

  • Macumber IR, Weiss NS, Halbach SM, Hanevold CD, Flynn JT (2016) The association of pediatric obesity with nocturnal non-dipping on 24-hour ambulatory BP monitoring. Am J Hypertens 29(5):647–652

    Article  Google Scholar 

  • Marks SD, Tullus K (2012) Update on imaging for suspected renovascular hypertension in children and adolescents. Curr Hypertens Rep 14(6):591–595. https://doi.org/10.1007/s11906-012-0308-1

    Article  CAS  Google Scholar 

  • Matteucci MC, Wuhl E, Picca S, Mastrostefano A, Rinelli G, Romano C, Rizzoni G, Mehls O, de Simone G, Schaefer F, Group ET (2006) Left ventricular geometry in children with mild to moderate chronic renal insufficiency. J Am Soc Nephrol 17(1):218–226. https://doi.org/10.1681/ASN.2005030276

    Article  Google Scholar 

  • Mattson DL (2003) Importance of the renal medullary circulation in the control of sodium excretion and BP. Am J Physiol Regul Integr Comp Physiol 284(1):R13–R27. https://doi.org/10.1152/ajpregu.00321.2002

    Article  CAS  Google Scholar 

  • Melton E, Qiu H (2021) Interleukin-1β in multifactorial hypertension: inflammation, vascular smooth muscle cell and extracellular matrix remodeling, and non-coding RNA regulation. Int J Mol Sci 22(16):8639. https://doi.org/10.3390/ijms22168639

    Article  CAS  Google Scholar 

  • Merrick MT, Ford DC, Ports KA, Guinn AS, Chen J, Klevens J, Metzler M, Jones CM, Simon TR, Daniel VM, Ottley P, Mercy JA (2019) Vital signs: estimated proportion of adult health problems attributable to adverse childhood experiences and implications for prevention – 25 states, 2015–2017. MMWR Morb Mortal Wkly Rep 68(44):999–1005

    Article  Google Scholar 

  • Mhanna MJ, Iqbal AM, Kaelber DC (2015) Weight gain and hypertension at three years of age and older in extremely low birth weight infants. J Neonatal Perinatal Med 8(4):363–369. https://doi.org/10.3233/NPM-15814080. PMID: 26836822

    Article  CAS  Google Scholar 

  • Mongeau JG, Biron P, Sing CF (1986) The influence of genetics and household environment upon the variability of normal BP: the Montreal Adoption Survey. Clin Exp Hypertens A 8(4–5):653–660

    CAS  Google Scholar 

  • Murphy MO, Huang H, Bauer JA, Schadler A, Makhoul M, Clasey JL, Chishti AS, Kiessling SG (2021) Impact of pediatric obesity on diurnal BP assessment and cardiovascular risk markers. Front Pediatr 9:596142. https://doi.org/10.3389/fped.2021.596142. PMID: 33748038; PMCID: PMC7969716

    Article  Google Scholar 

  • National High BP Education Program Working Group on High BP in C, Adolescents (2004) The fourth report on the diagnosis, evaluation, and treatment of high BP in children and adolescents. Pediatrics 114 (2 Suppl 4th Report):555–576

    Google Scholar 

  • Niiranen TJ, McCabe EL, Larson MG, Henglin M, Lakdawala NK, Vasan RS, Cheng S (2017) Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study. BMJ 12(357):j1949. https://doi.org/10.1136/bmj.j1949. PMID: 28500036; PMCID: PMC5430541

    Article  Google Scholar 

  • Ostchega Y, Carroll M, Prineas RJ, McDowell MA, Louis T, Tilert T (2009) Trends of elevated BP among children and adolescents: data from the National Health and Nutrition Examination Survey1988–2006. Am J Hypertens 22(1):59–67. https://doi.org/10.1038/ajh.2008.312

    Article  Google Scholar 

  • Pludowski P, Litwin M, Niemirska A, Jaworski M, Sladowska J, Kryskiewicz E, Karczmarewicz E, Neuhoff-Murawska J, Wierzbicka A, Lorenc RS (2009) Accelerated skeletal maturation in children with primary hypertension. Hypertension 54(6):1234–1239. https://doi.org/10.1161/HYPERTENSIONAHA.109.139949

    Article  CAS  Google Scholar 

  • Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS (2020) Hypertension Canada’s 2020 comprehensive guidelines for the prevention, diagnosis, risk assessment, and treatment of hypertension in adults and children. Can J Cardiol 36(5):596–624. https://doi.org/10.1016/j.cjca.2020.02.086. PMID: 32389335

    Article  Google Scholar 

  • Ramaswamy P, Chikkabyrappa S, Donda K, Osmolovsky M, Rojas M, Rafii D (2016) Relationship of ambulatory BP and body mass index to left ventricular mass index in pediatric patients with casual hypertension. J Am Soc Hypertens 10(2):108–114. https://doi.org/10.1016/j.jash.2015.11.009

    Article  Google Scholar 

  • Redwine KM, Acosta AA, Poffenbarger T, Portman RJ, Samuels J (2012) Development of hypertension in adolescents with pre-hypertension. J Pediatr 160(1):98–103. https://doi.org/10.1016/j.jpeds.2011.07.010

    Article  Google Scholar 

  • Rios-Leyvraz M, Bloetzer C, Chatelan A, Bochud M, Burnier M, Santschi V, Paradis G, Tabin R, Bovet P, Chiolero A (2019) Sodium intake and BP in children with clinical conditions: a systematic review with meta-analysis. J Clin Hypertens (Greenwich) 21:118–126. https://doi.org/10.1111/jch.13436

    Article  CAS  Google Scholar 

  • Rosner B, Cook NR, Daniels S, Falkner B (2013) Childhood BP trends and risk factors for high BP: the NHANES experience 1988–2008. Hypertension 62(2):247–254. https://doi.org/10.1161/HYPERTENSIONAHA.111.00831

    Article  CAS  Google Scholar 

  • Rudnicki M, Mayer G (2009) Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. Pharmacogenomics 10(3):463–476. https://doi.org/10.2217/14622416.10.3.463

    Article  CAS  Google Scholar 

  • Seeman T, Hradský O, Gilík J (2016) Nocturnal BP non-dipping is not associated with increased left ventricular mass index in hypertensive children without end-stage renal failure. Eur J Pediatr 175(8):1091–1097. https://doi.org/10.1007/s00431-016-2749-z. Epub 2016 Jun 25. PMID: 27344339

    Article  Google Scholar 

  • Sheppard R (2010) Vascular tone and the genomics of hypertension. Heart Fail Clin 6(1):45–53. https://doi.org/10.1016/j.hfc.2009.08.009

    Article  Google Scholar 

  • Simonetti GD, von Vigier RO, Wuhl E, Mohaupt MG (2008) Ambulatory arterial stiffness index is increased in hypertensive childhood disease. Pediatr Res 64(3):303–307. https://doi.org/10.1203/PDR.0b013e31817d9bc5

    Article  Google Scholar 

  • Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wuhl E (2011) Determinants of BP in preschool children: the role of parental smoking. Circulation 123(3):292–298. https://doi.org/10.1161/CIRCULATIONAHA.110.958769

    Article  Google Scholar 

  • Slagman MC, Waanders F, Hemmelder MH et al (2011) Moderate dietary sodium restriction added to angiotensin converting enzyme inhibition compared with dual blockade in lowering proteinuria and blood pressure: randomised controlled trial. BMJ 343:d4366

    Article  Google Scholar 

  • Song P PhD, Zhang Y MSc, Yu J MD, Zha M MD, Zhu Y PhD, Rahimi K DM, Rudan I PhD (2019) Global prevalence of hypertension in children a systematic review and meta-analysis. JAMA Pediatr 173(12):1154–1163

    Google Scholar 

  • Steinberger J, Daniels SR, Hagberg N, Isasi CR, Kelly AS, Lloyd-Jones D, Pate RR, Pratt C, Shay CM, Towbin JA, Urbina E, Van Horn LV, Zachariah JP, American Heart Association Atherosclerosis H, Obesity in the Young Committee of the Council on Cardiovascular Disease in the Y, Council on C, Stroke N, Council on E, Prevention, Council on Functional G, Translational B, Stroke C (2016) Cardiovascular health promotion in children: challenges and opportunities for 2020 and beyond: a scientific statement from the American Heart Association. Circulation. https://doi.org/10.1161/CIR.0000000000000441

  • Steinthorsdottir SD, Eliasdottir SB, Indridason OS, Agustsdottir IM, Palsson R, Edvardsson VO (2011) Prevalence of hypertension in 9- to 10-year-old Icelandic school children. J Clin Hypertens (Greenwich) 13(10):774–779

    Article  Google Scholar 

  • Su S, Wang X, Pollock JS, Pollock JS, Treiber FA, Xu X, Snieder H, McCall WV, Stefanek M, Harshfield GA (2015) Adverse childhood experiences and BP trajectories from childhood to young adulthood: the Georgia stress and Heart study. Circulation 131(19):1674–1681

    Article  Google Scholar 

  • Suglia SF, Sapra KJ, Koenen KC (2015) Violence and cardiovascular health: a systematic review. Am J Prev Med 48(2):205–212

    Article  Google Scholar 

  • Sulakova T, Janda J, Cerna J, Janstova V, Sulakova A, Slany J, Feber J (2009) Arterial HTN in children with T1DM – frequent and not easy to diagnose. Pediatr Diabetes 10(7):441–448. https://doi.org/10.1111/j.1399-5448.2009.00514.x

    Article  Google Scholar 

  • Sun SS, Grave GD, Siervogel RM, Pickoff AA, Arslanian SS, Daniels SR (2007) Systolic BP in childhood predicts hypertension and metabolic syndrome later in life. Pediatrics 119(2):237–246. https://doi.org/10.1542/peds.2006-2543

    Article  Google Scholar 

  • Teng H, Hu J, Ge W, Dai Q, Liu J, Xiao C, Yin J, Zhu X (2021) Body mass index trajectories during 6–18 years old and the risk of hypertension in young adult: a longitudinal study in Chinese population. Int J Hypertens 15:6646868. https://doi.org/10.1155/2021/6646868. PMID: 34327015; PMCID: PMC8302370

    Article  Google Scholar 

  • Timofeeva AV, Goryunova LE, Khaspekov GL, Kovalevskii DA, Scamrov AV, Bulkina OS, Karpov YA, Talitskii KA, Buza VV, Britareva VV, Beabealashvilli R (2006) Altered gene expression pattern in peripheral blood leukocytes from patients with arterial hypertension. Ann N Y Acad Sci 1091:319–335. https://doi.org/10.1196/annals.1378.077

    Article  CAS  Google Scholar 

  • Toemen L, de Jonge LL, Gishti O, van Osch-Gevers L, Taal HR, Steegers EA, Hofman A, Helbing WA, Jaddoe VW (2016) Longitudinal growth during fetal life and infancy and cardiovascular outcomes at school-age. J Hypertens 34(7):1396–1406. https://doi.org/10.1097/HJH.0000000000000947. PMID: 27115338.doi:10.1161/HYPERTENSIONAHA.110.155721

  • Torrance B, McGuire KA, Lewanczuk R, McGavock J (2007) Overweight, physical activity and high BP in children: a review of the literature. Vasc Health Risk Manag 3(1):139–149

    Google Scholar 

  • Towner EK, Kapur G, Carcone AI, Janisse J, Ellis DA, Catherine Jen KL, Naar S (2019) Physical activity as a predictor of changes in systolic BP for African American adolescents seeking treatment for obesity. J Adolesc Health 65(3):430–432. https://doi.org/10.1016/j.jadohealth.2019.04.001. Epub 2019 Jun 18. PMID: 31227385

    Article  Google Scholar 

  • Tu W, Eckert GJ, Saha C, Pratt JH (2009) Synchronization of adolescent BP and pubertal somatic growth. J Clin Endocrinol Metab 94(12):5019–5022. https://doi.org/10.1210/jc.2009-0997

    Article  CAS  Google Scholar 

  • Urbina EM, Kimball TR, McCoy CE, Khoury PR, Daniels SR, Dolan LM (2009) Youth with obesity and obesity-related type 2 diabetes mellitus demonstrate abnormalities in carotid structure and function. Circulation 119(22):2913–2919. https://doi.org/10.1161/CIRCULATIONAHA.108.830380

    Article  CAS  Google Scholar 

  • Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM (2011) Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens (Greenwich) 13(5):332–342. https://doi.org/10.1111/j.1751-7176.2011.00471.x

    Article  Google Scholar 

  • US Department of Agriculture and US Department of Health and Human Services (2020) Dietary guidelines for Americans, 2020–2025, 9th edn. Appendix 1: Nutritional Goals for Age-Sex Groups, pp 131–133. https://www.dietaryguidelines.gov/sites/default/files/2020/12/Dietary_Guidelines_for_Americans_2020-2025.pdf

  • Vlahandonis A, Yiallourou SR, Sands SA et al (2014) Long-term changes in blood pressure control in elementary school-aged children with sleep-disordered breathing. Sleep Med 15:83

    Article  Google Scholar 

  • Wang Y, Wang JG (2019) Genome-wide association studies of hypertension and several other cardiovascular diseases. Pulse (Basel) 6(3–4):169–186. https://doi.org/10.1159/000496150. Epub 2019 Feb 5. PMID: 31049317; PMCID: PMC6489084

    Article  Google Scholar 

  • Westerståhl M, Hedvall Kallerman P, Hagman E, Ek AE, Rössner SM, Marcus C (2014) Nocturnal BP non-dipping is prevalent in severely obese, prepubertal and early pubertal children. Acta Paediatr 103(2):225–230

    Article  Google Scholar 

  • Whincup PH, Gilg JA, Donald AE, Katterhorn M, Oliver C, Cook DG, Deanfield JE (2005) Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors. Circulation 112(12):1789–1797. https://doi.org/10.1161/CIRCULATIONAHA.104.532663

    Article  CAS  Google Scholar 

  • World Health Organization (2013) A global brief on hypertension 2013, document number: WHO/DCO/WHD/2013.2. WHO Press, Geneva

    Google Scholar 

  • Yamaguchi I, Flynn JT (2009) Pathophysiology of hypertension. In: Avner E, Harmon W, Niaudet P, Yoshikawa N (eds) Pediatric nephrology, 6th edn. Lippincott Williams and Wilkins, Philadelphia, pp 1485–1518

    Chapter  Google Scholar 

  • Yang L, Kelishadi R, Hong YM, Khadilkar A, Nawarycz T, Krzywińska-Wiewiorowska M, Aounallah-Skhiri H, Motlagh ME, Kim HS, Khadilkar V, Krzyżaniak A, Ben Romdhane H, Heshmat R, Chiplonkar S, Stawińska-Witoszyńska B, El Ati J, Qorbani M, Kajale N, Traissac P, Ostrowska-Nawarycz L, Ardalan G, Ekbote V, Zhao M, Heiland EG, Liang Y, Xi B (2019) Impact of the 2017 American Academy of Pediatrics guideline on hypertension prevalence compared with the fourth report in an international cohort. Hypertension 74(6):1343–1348

    Article  CAS  Google Scholar 

  • Yang L, Magnussen CG, Yang L, Bovet P, Xi B (2020) Elevated blood pressure in childhood or adolescence and cardiovascular outcomes in adulthood a systematic review. Hypertension 75:948–955

    Article  CAS  Google Scholar 

  • Zilioli S, Gómez JM, Jiang Y, Rodriguez-Stanley J (2021) Childhood socioeconomic status and cardiometabolic health: a test of the John Henryism hypothesis in African American elders. J Gerontol A Biol Sci Med Sci:glab280. https://doi.org/10.1093/gerona/glab280. Epub ahead of print. PMID: 34569595

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Grewal, M.K., Mattoo, T.K., Kapur, G. (2023). Primary Hypertension in Children. In: Flynn, J.T., Ingelfinger, J.R., Brady, T.M. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-031-06231-5_20

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