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Vascular Lesions of the Breast

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A Comprehensive Guide to Core Needle Biopsies of the Breast

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Abstract

Vascular tumors commonly arise in the breast or overlying skin. Although classification as benign or malignant is usually straightforward in resection specimens, rendering a definitive diagnosis on core biopsy samples is often difficult because of limited sampling. Whereas benign vascular lesions are well circumscribed and lack endothelial hyperplasia, severe cytologic atypia, and anastomosing vasculature, malignant vascular tumors are characterized by complex, anastomosing vascular channels that infiltrate the dermis and/or breast parenchyma. Included within this morphological spectrum are atypical vascular lesions associated with prior radiation therapy. As with other differential diagnoses in the setting of breast core biopsies, correlation with clinical and radiologic findings is critical. It is also important to remember that complete diagnostic characterization of some vascular lesions may be possible only after surgical excision. This chapter covers a multitude of benign and malignant vascular lesions of the breast and discusses their diagnostic features and differential diagnoses.

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Authors and Affiliations

  1. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA

    Melinda E. Sanders & Justin M. Cates

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  1. Melinda E. Sanders
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  2. Justin M. Cates
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Correspondence to Melinda E. Sanders .

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  1. Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA

    Sandra J. Shin

  2. Department of Pathology, University of California San Francisco, San Francisco, CA, USA

    Yunn-Yi Chen

  3. Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA

    Paula S. Ginter

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Sanders, M.E., Cates, J.M. (2022). Vascular Lesions of the Breast. In: Shin, S.J., Chen, YY., Ginter, P.S. (eds) A Comprehensive Guide to Core Needle Biopsies of the Breast . Springer, Cham. https://doi.org/10.1007/978-3-031-05532-4_17

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