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Exploiting Hyaluronan-CD44 Network in Tumor Therapy

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The Extracellular Matrix and the Tumor Microenvironment

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 11))

Abstract

Cancer is one of the leading causes of death worldwide. During tumor development and progression, extracellular matrix is being intensively re-organized. One of the most abundant molecules in the extracellular matrix is the polysaccharide hyaluronan. Hyaluronan accumulation and high CD44 expression—the major hyaluronan cellular receptor—correlate with higher malignant states of cancer cells, increased incidence of metastases and poor prognosis of the patients in a wide array of tumor types. Thus, hyaluronan interaction with CD44 emerges as an important target for cancer treatment. In this chapter, recent efforts to exploit hyaluronan/CD44 network for tumor therapy are being discussed. Overall, there is a wide variety of tools available to target this system like anti-CD44 antibodies and peptides, gene therapies against CD44, nanotechnology and modified-hyaluronan. Initial in vivo evidence shows promising results, nominating hyaluronan/CD44 network targeting as a potent candidate to be introduced into clinical settings for tumor therapy.

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Authors and Affiliations

  1. Biochemistry, Biochemical Analysis & Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece

    Theodoros T. Karalis & Spyros S. Skandalis

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  1. Theodoros T. Karalis
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  2. Spyros S. Skandalis
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Correspondence to Spyros S. Skandalis .

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  1. Department of Pathology & Experimental Cancer Research, Semmelweis University, Budapest, Hungary

    Ilona Kovalszky

  2. Department for Life Quality Study, University of Bologna, Rimini, Italy

    Marco Franchi

  3. Laboratorio de Microambiente Tumoral, National University of Northwestern Buen, Junin, Argentina

    Laura D. Alaniz

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Karalis, T.T., Skandalis, S.S. (2022). Exploiting Hyaluronan-CD44 Network in Tumor Therapy. In: Kovalszky, I., Franchi, M., Alaniz, L.D. (eds) The Extracellular Matrix and the Tumor Microenvironment. Biology of Extracellular Matrix, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-99708-3_18

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