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Cost Estimates Associated with Diagnosis and Treatment of Endometriosis

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Endometriosis and Adenomyosis

Abstract

Endometriosis is a benign gynaecologic condition that is prevalent in the general population. Due to its high prevalence and significant impact on quality of life, endometriosis can be associated with substantial healthcare resource utilization. This problem is compounded by the propensity of patients to undergo multiple unnecessary tests and interventions across a variety of settings before obtaining an appropriate diagnosis or treatment. This is of particular concern in resource-constrained healthcare systems. Many studies have attempted to elucidate the direct and indirect costs associated with this disease to understand the societal burden of endometrosis. Study methodology and limitations in quantifying costs have made it particularly difficult to capture the entire spectrum of costs associated with endometriosis and healthcare expenditures. The economic burden of endometriosis has been previously compared to that of other chronic diseases such as diabetes and rheumatoid arthritis, demonstrating that there is growing concern around how this disease is diagnosed and managed in a manner that is cost-effective. This chapter highlights the different cost drivers and the many hidden factors that play a role in raising the global economic burden of endometriosis.

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References

  1. American College of Obstetricians and Gynecologists. Management of endometriosis. ACOG Practice bulletin no. 114. Obstetr Gynecol. 2010;116(1):225–36.

    Google Scholar 

  2. Johnson NP, Hummelshoj L, Adamson GD, Keckstein J, Taylor HS, Abrao MS, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017;32(2):315–24.

    Article  PubMed  Google Scholar 

  3. Zondervan KT, Becker CM, Koga K, Missmer SA, Taylor RN, Viganò P. Endometriosis (Primer). Nature Reviews: Disease Primers; 2018.

    Google Scholar 

  4. Santulli P, Marcellin L, Tosti C, Chouzenoux S, Cerles O, Borghese B, et al. MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis? Expert Opin Ther Targets. 2015;19(11):1465–83.

    Article  CAS  PubMed  Google Scholar 

  5. Reis FM, Santulli P, Marcellin L, Borghese B, Lafay-Pillet MC, Chapron C. Superficial peritoneal endometriosis: clinical characteristics of 203 confirmed cases and 1292 endometriosis-free controls. Reprod Sci. 2020;27(1):309–15.

    Article  CAS  PubMed  Google Scholar 

  6. Abbas S, Ihle P, Koster I, Schubert I. Prevalence and incidence of diagnosed endometriosis and risk of endometriosis in patients with endometriosis-related symptoms: findings from a statutory health insurance- based cohort in Germany. Eur J Obstet Gynecol Reprod Biol. 2012;160:79–83.

    Article  PubMed  Google Scholar 

  7. Zondervan KT, Cardon LR, Kennedy SH. The genetic basis of endometriosis. Curr Opin Obstet Gynecol. 2001;13(3):309–14.

    Article  CAS  PubMed  Google Scholar 

  8. Mihalyi A, Mutinda KC, Simsa P, Debrock S, Mwenda JM, D'Hooghe TM. Role of immunologic and inflammatory factors in the development of endometriosis: indications for treatment strategies. Clin Pract. 2005;2(4):623.

    CAS  Google Scholar 

  9. Adamson GD, Kennedy S, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation; 2010. p. 3–6.

    Google Scholar 

  10. Nnoaham KE, Hummelshoj L, Webster P, d’Hooghe T, de Cicco Nardone F, de Cicco Nardone C, et al. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011;96(2):366–73.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin N Am. 1997;24(2):235–58.

    Article  CAS  Google Scholar 

  12. Louis GM, Hediger ML, Peterson CM, Croughan M, Sundaram R, Stanford J, et al. Incidence of endometriosis by study population and diagnostic method: the ENDO study. Fertil Steril. 2011;96(2):360–5.

    Article  Google Scholar 

  13. Barbieri RL. Etiology and epidemiology of endometriosis. Am J Obstet Gynecol. 1990;162(2):565–7.

    Article  CAS  PubMed  Google Scholar 

  14. Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009;92(1):68–74.

    Article  PubMed  Google Scholar 

  15. Whitaker LH, Reid J, Choa A, McFee S, Seretny M, Wilson J, et al. An exploratory study into objective and reported characteristics of neuropathic pain in women with chronic pelvic pain. PLoS One. 2016;11(4):e0151950.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Mowers EL, Lim CS, Skinner B, Mahnert N, Kamdar N, Morgan DM, et al. Prevalence of endometriosis during abdominal or laparoscopic hysterectomy for chronic pelvic pain. Obstet Gynecol. 2016;127(6):1045–53.

    Article  PubMed  Google Scholar 

  17. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364:1789–99.

    Article  PubMed  Google Scholar 

  18. Gao X, Outley J, Botteman M, Spalding J, Simon JA, Pashos CL. Economic burden of endometriosis. Fertil Steril. 2006;86(6):1561–72.

    Article  PubMed  Google Scholar 

  19. Gao X, Yeh YC, Outley J, Simon J, Botteman M, Spalding J. Health-related quality of life burden of women with endometriosis: a literature review. Curr Med Res Opin. 2006;22(9):1787–97.

    Article  PubMed  Google Scholar 

  20. Surtees PG, Wainwright NW, Khaw KT, Day NE. Functional health status, chronic medical conditions and disorders of mood. Br J Psychiatry. 2003;183(4):299–303.

    Article  PubMed  Google Scholar 

  21. Fourquet J, Báez L, Figueroa M, Iriarte RI, Flores I. Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity. Fertil Steril. 2011;96(1):107–12.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Zhao SZ, Wong JM, Davis MB, Gersh GE, Johnson KE. The cost of inpatient endometriosis treatment: an analysis based on the Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Am J Manag Care. 1998;4(8):1127–34.

    CAS  PubMed  Google Scholar 

  23. Senapati S, Sammel MD, Morse C, Barnhart KT. Impact of endometriosis on in vitro fertilization outcomes: an evaluation of the Society for Assisted Reproductive Technologies Database. Fertil Steril. 2016;106(1):164–71.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Laganà AS, La Rosa VL, Rapisarda AM, Valenti G, Sapia F, Chiofalo B, et al. Anxiety and depression in patients with endometriosis: impact and management challenges. Int J Women's Health. 2017;9:323.

    Article  Google Scholar 

  25. Facchin F, Barbara G, Dridi D, Alberico D, Buggio L, Somigliana E, et al. Mental health in women with endometriosis: searching for predictors of psychological distress. Hum Reprod. 2017;32(9):1855–61.

    Article  CAS  PubMed  Google Scholar 

  26. Aerts L, Grangier L, Streuli I, Dällenbach P, Marci R, Wenger JM, et al. Psychosocial impact of endometriosis: From co-morbidity to intervention. Best Pract Res Clin Obstet Gynaecol. 2018;50:2–10.

    Article  PubMed  Google Scholar 

  27. Culley L, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, et al. The social and psychological impact of endometriosis on women's lives: a critical narrative review. Hum Reprod Update. 2013;19(6):625–39.

    Article  PubMed  Google Scholar 

  28. Moradi M, Parker M, Sneddon A, Lopez V, Ellwood D. Impact of endometriosis on women’s lives: a qualitative study. BMC Womens Health. 2014;14(1):123.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Zannoni L, Giorgi M, Spagnolo E, Montanari G, Villa G, Seracchioli R. Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents. J Pediatr Adolesc Gynecol. 2014;27(5):258–65.

    Article  PubMed  Google Scholar 

  30. Soliman AM, Coyne KS, Gries KS, Castelli-Haley J, Snabes MC, Surrey ES. The effect of endometriosis symptoms on absenteeism and presenteeism in the workplace and at home. J Manag Care Spec Pharm. 2017;23(7):745–54.

    PubMed  Google Scholar 

  31. Simoens S, Hummelshoj L, D'Hooghe T. Endometriosis: cost estimates and methodological perspective. Hum Reprod Update. 2007;13(4):395–404.

    Article  CAS  PubMed  Google Scholar 

  32. Simoens S, Dunselman G, Dirksen C, Hummelshoj L, Bokor A, Brandes I, et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres. Hum Reprod. 2012;27(5):1292–9.

    Article  PubMed  Google Scholar 

  33. Soliman AM, Yang H, Du EX, Kelley C, Winkel C. The direct and indirect costs associated with endometriosis: a systematic literature review. Hum Reprod. 2016;31(4):712–22.

    Article  PubMed  Google Scholar 

  34. Yeung PP Jr, Shwayder J, Pasic RP. Laparoscopic management of endometriosis: comprehensive review of best evidence. J Minim Invasive Gynecol. 2009;16(3):269–81.

    Article  PubMed  Google Scholar 

  35. Luciano AA, Lowney J, Jacobs SL. Endoscopic treatment of endometriosis-associated infertility. Therapeutic, economic and social benefits. J Reprod Med. 1992;37(7):573–6.

    CAS  PubMed  Google Scholar 

  36. Medeiros LR, Rosa DD, Bozzetti MC, Fachel JM, Furness S, Garry R, Rosa MI, Stein AT. Laparoscopy versus laparotomy for benign ovarian tumour. Cochrane Database Syst Rev. 2009;2:CD004751.

    Google Scholar 

  37. Chapron C, Cravello L, Chopin N, Kreiker G, Blanc B, Dubuisson JB. Complications during set-up procedures for laparoscopy in gynecology: open laparoscopy does not reduce the risk of major complications. Acta Obstet Gynecol Scand. 2003;82(12):1125–9.

    Article  CAS  PubMed  Google Scholar 

  38. Ling FW. Randomized controlled trial of depot leuprolide in patients with chronic pelvic pain and clinically suspected endometriosis. Obstet Gynecol. 1999;93(1):51–8.

    CAS  PubMed  Google Scholar 

  39. Kennedy S, Bergqvist A, Chapron C, D'Hooghe T, Dunselman G, Greb R, et al. On behalf of the ESHRE Special Interest Group for Endometriosis and Endometrium Guideline Development Group. Hum Reprod. 2005;20(10):2698–704.

    Article  PubMed  Google Scholar 

  40. Heim LJ. Evaluation and differential diagnosis of dyspareunia. Am Fam Physician. 2001;63(8):1535.

    CAS  PubMed  Google Scholar 

  41. Brenner PF. Differential diagnosis of abnormal uterine bleeding. Am J Obstet Gynecol. 1996;175(3):766–9.

    Article  CAS  PubMed  Google Scholar 

  42. Mounsey A, Wilgus A, Slawson DC. Diagnosis and management of endometriosis. Am Fam Physician. 2006;74(4):594–600.

    PubMed  Google Scholar 

  43. Ay W. The significance of diagnostic delay in endometriosis. MOJ Womens Health. 2016;2:10–1.

    Google Scholar 

  44. Taylor HS, Adamson GD, Diamond MP, Goldstein SR, Horne AW, Missmer SA, et al. An evidence-based approach to assessing surgical versus clinical diagnosis of symptomatic endometriosis. Int J Gynecol Obstet. 2018;142(2):131–42.

    Article  Google Scholar 

  45. Nisenblat V, Bossuyt PM, Farquhar C, Johnson N, Hull ML. Imaging modalities for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;2:CD009591.

    PubMed  Google Scholar 

  46. Eskenazi B, Warner M, Bonsignore L, Olive D, Samuels S, Vercellini P. Validation study of nonsurgical diagnosis of endometriosis. Fertil Steril. 2001;76(5):929–35.

    Article  CAS  PubMed  Google Scholar 

  47. Leyland N, Casper R, Laberge P, Singh SS, Allen L, Arendas K, et al. Endometriosis: diagnosis and management. J Endometr. 2010;2(3):107–34.

    Article  Google Scholar 

  48. Practice Committee of the American Society for Reproductive Medicine. Treatment of pelvic pain associated with endometriosis: a committee opinion. Fertil Steril. 2014;101(4):927–35.

    Article  Google Scholar 

  49. Vercellini P, Buggio L, Frattaruolo MP, Borghi A, Dridi D, Somigliana E. Medical treatment of endometriosis-related pain. Best Pract Res Clin Obstet Gynaecol. 2018;51:68–91.

    Article  PubMed  Google Scholar 

  50. Frishman GN, Salak JR. Conservative surgical management of endometriosis in women with pelvic pain. J Minim Invasive Gynecol. 2006;13(6):546–58.

    Article  PubMed  Google Scholar 

  51. Chiaffarino F, Cipriani S, Ricci E, Mauri PA, Esposito G, Barretta M, et al. Endometriosis and irritable bowel syndrome: a systematic review and meta-analysis. Arch Gynecol Obstet. 2020;303(1):17–25.

    Article  PubMed  Google Scholar 

  52. Ballard K, Lowton K, Wright J. What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis. Fertil Steril. 2006;86(5):1296–301.

    Article  PubMed  Google Scholar 

  53. Prast J, Oppelt P, Shamiyeh A, Shebl O, Brandes I, Haas D. Costs of endometriosis in Austria: a survey of direct and indirect costs. Arch Gynecol Obstet. 2013;288(3):569–76.

    Article  PubMed  Google Scholar 

  54. Matsuzaki S, Canis M, Pouly JL, Rabischong B, Botchorishvili R, Mage G. Relationship between delay of surgical diagnosis and severity of disease in patients with symptomatic deep infiltrating endometriosis. Fertil Steril. 2006;86(5):1314–6.

    Article  PubMed  Google Scholar 

  55. Arruda MS, Petta CA, Abrão MS, Benetti-Pinto CL. Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women. Hum Reprod. 2003;18(4):756–9.

    Article  CAS  PubMed  Google Scholar 

  56. Husby GK, Haugen RS, Moen MH. Diagnostic delay in women with pain and endometriosis. Acta Obstet Gynecol Scand. 2003;82(7):649–53.

    Article  PubMed  Google Scholar 

  57. Soliman AM, Fuldeore M, Snabes MC. Factors associated with time to endometriosis diagnosis in the United States. J Women's Health. 2017;26(7):788–97.

    Article  Google Scholar 

  58. Surrey E, Soliman AM, Trenz H, Blauer-Peterson C, Sluis A. Impact of endometriosis diagnostic delays on healthcare resource utilization and costs. Adv Ther. 2020;37(3):1087–99.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Soliman AM, Surrey ES, Bonafede M, Nelson JK, Vora JB, Agarwal SK. Health care utilization and costs associated with endometriosis among women with medicaid insurance. J Manag Care Spec Pharm. 2019;25(5):566–72.

    PubMed  Google Scholar 

  60. Fuldeore M, Yang H, Du EX, Soliman AM, Wu EQ, Winkel C. Healthcare utilization and costs in women diagnosed with endometriosis before and after diagnosis: a longitudinal analysis of claims databases. Fertil Steril. 2015;103(1):163–71.

    Article  PubMed  Google Scholar 

  61. Soliman AM, Surrey E, Bonafede M, Nelson JK, Castelli-Haley J. Real-world evaluation of direct and indirect economic burden among endometriosis patients in the United States. Adv Ther. 2018;35(3):408–23.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Mirkin D, Murphy-Barron C, Iwasaki K. Actuarial analysis of private payer administrative claims data for women with endometriosis. J Manag Care Pharm. 2007;13:262–72.

    Article  PubMed  Google Scholar 

  63. Fuldeore M, Chwalisz K, Marx S, Wu N, Boulanger L, Ma L, et al. Surgical procedures and their cost estimates among women with newly diagnosed endometriosis: a US database study. J Med Econ. 2011;14(1):115–23.

    Article  CAS  PubMed  Google Scholar 

  64. Nisenblat V, Bossuyt PM, Shaikh R, Farquhar C, Jordan V, Scheffers CS, et al. Blood biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;5:CD012179.

    Google Scholar 

  65. Moore J, Copley S, Morris J, Lindsell D, Golding S, Kennedy S. A systematic review of the accuracy of ultrasound in the diagnosis of endometriosis. Ultrasound Obstetr Gynecol. 2002;20(6):630–4.

    Article  CAS  Google Scholar 

  66. Exacoustos C, Manganaro L, Zupi E. Imaging for the evaluation of endometriosis and adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2014;28(5):655–81.

    Article  PubMed  Google Scholar 

  67. Testa AC, Timmerman D, Van Holsbeke C, Zannoni GF, Fransis S, Moerman P, et al. Ovarian cancer arising in endometrioid cysts: ultrasound findings. Ultrasound Obstet Gynecol. 2011;38(1):99–106.

    Article  CAS  PubMed  Google Scholar 

  68. Hudelist G, English J, Thomas AE, Tinelli A, Singer CF, Keckstein J. Diagnostic accuracy of transvaginal ultrasound for non-invasive diagnosis of bowel endometriosis: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2011;37(3):257–63.

    Article  CAS  PubMed  Google Scholar 

  69. Kinkel K, Frei KA, Balleyguier C, Chapron C. Diagnosis of endometriosis with imaging: a review. Eur Radiol. 2006;16(2):285–98.

    Article  PubMed  Google Scholar 

  70. Leonardi M, Robledo KP, Espada M, Vanza K, Condous G. SonoPODography: a new diagnostic technique for visualizing superficial endometriosis. Eur J Obstet Gynecol Reprod Biol. 2020;254:124–31.

    Article  CAS  PubMed  Google Scholar 

  71. Dmowski WP, Lesniewicz R, Rana N, Pepping P, Noursalehi M. Changing trends in the diagnosis of endometriosis: a comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility. Fertil Steril. 1997;67(2):238–43.

    Article  CAS  PubMed  Google Scholar 

  72. Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10(5):261.

    Article  CAS  PubMed  Google Scholar 

  73. Johnson NP, Hummelshoj L, World Endometriosis Society Montpellier Consortium, Abrao MS, Adamson GD, Allaire C, Amelung V, Andersson E, Becker C, Birna Árdal KB, Bush D. Consensus on current management of endometriosis. Hum Reprod. 2013;28(6):1552–68.

    Article  Google Scholar 

  74. Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, et al. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400–12.

    Article  CAS  PubMed  Google Scholar 

  75. Clayton RD, Hawe JA, Love JC, Wilkinson N, Garry R. Recurrent pain after hysterectomy and bilateral salpingo-oophorectomy for endometriosis: evaluation of laparoscopic excision of residual endometriosis. BJOG Int J Obstet Gynaecol. 1999;106(7):740–4.

    Article  CAS  Google Scholar 

  76. Vercellini P, Buggio L, Berlanda N, Barbara G, Somigliana E, Bosari S. Estrogen-progestins and progestins for the management of endometriosis. Fertil Steril. 2016;106(7):1552–71.

    Article  CAS  PubMed  Google Scholar 

  77. Olive DL, Schwartz LB. Endomeuiosis. N Engl J Med. 1993;328(24):1.

    Google Scholar 

  78. Allaire C, Long AJ, Bedaiwy MA, Yong PJ. Interdisciplinary teams in endometriosis care. In Seminars in reproductive medicine 2020. Thieme Medical Publishers.

    Google Scholar 

  79. Bodner C, Vale L, Ratcliffe J, Farrar S. Using economics alongside medical audit. A case study of the management of endometriosis. Health Bull. 1996;54(3):204–11.

    CAS  Google Scholar 

  80. Grand TS, Basarir H, Jackson LJ. The cost-effectiveness of oral contraceptives compared to ‘no hormonal treatment for endometriosis-related pain: An economic evaluation. PLoS One. 2019;14(1):e0210089.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Pearson S, Pickersgill A. The costs of endometriosis. InGynaecol. Forum. 2004;9:23–7.

    Google Scholar 

  82. Guzick DS, Huang LS, Broadman BA, Nealon M, Hornstein MD. Randomized trial of leuprolide versus continuous oral contraceptives in the treatment of endometriosis-associated pelvic pain. Fertil Steril. 2011;95(5):1568–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Surrey E. An economically rational method of managing early-stage endometriosis. Med Interface. 1997;10(3):119.

    CAS  PubMed  Google Scholar 

  84. Lindheim SR. Chronic pelvic pain: presumptive diagnosis and therapy using GnRH agonists. Int J Fertil Womens Med. 1999;44(3):131–8.

    CAS  PubMed  Google Scholar 

  85. Kephart W. Evaluation of Lovelace Health Systems chronic pelvic pain protocol. Am J Manag Care. 1999;5(5 Suppl):S309.

    CAS  PubMed  Google Scholar 

  86. Armstrong C. ACOG updates guideline on diagnosis and treatment of endometriosis. Am Fam Physician. 2011;83(1):84.

    Google Scholar 

  87. Chen I, Thavorn K, Yong PJ, Choudhry AJ, Allaire C. Hospital-associated cost of endometriosis in Canada: a population-based study. J Minim Invasive Gynecol. 2020;27(5):1178–87.

    Article  PubMed  Google Scholar 

  88. Winkel CA. Modeling of medical and surgical treatment costs of chronic pelvic pain: new paradigms for making clinical decisions. Am J Manag Care. 1999;5(5 Suppl):S276–90.

    CAS  PubMed  Google Scholar 

  89. Bedaiwy MA, Barker NM. Evidence based surgical management of endometriosis. Middle East Fertil Soc J. 2012;17(1):57–60.

    Article  Google Scholar 

  90. Cohen MM, Young W. Costs of hysterectomy: does surgical approach make a difference? J Women's Health. 1998;7(7):885–92.

    Article  CAS  Google Scholar 

  91. Chapron C, Fernandez B, Dubuisson JB. Total hysterectomy for benign pathologies: direct costs comparison between laparoscopic and abdominal hysterectomy. Europ J Obstetr Gynecol Reprod Biol. 2000;89(2):141–7.

    Article  CAS  Google Scholar 

  92. Liu H, Lu D, Wang L, et al. Robotic surgery for benign gynaecological disease. Cochrane Database Syst Rev. 2012;2:CD008978.

    Google Scholar 

  93. Kristensen SE, Mosgaard BJ, Rosendahl M, Dalsgaard T, Bjørn SF, Frøding LP, et al. Robot-assisted surgery in gynecological oncology: current status and controversies on patient benefits, cost and surgeon conditions–a systematic review. Acta Obstet Gynecol Scand. 2017;96(3):274–85.

    Article  PubMed  Google Scholar 

  94. Soto E, Luu TH, Liu X, Magrina JF, Wasson MN, Einarsson JI, et al. Laparoscopy vs. Robotic Surgery for Endometriosis (LAROSE): a multicenter, randomized, controlled trial. Fertil Steril. 2017;107(4):996–1002.

    Article  PubMed  Google Scholar 

  95. Pache B, Joliat GR, Hübner M, Grass F, Demartines N, Mathevet P, et al. Cost-analysis of Enhanced Recovery After Surgery (ERAS) program in gynecologic surgery. Gynecol Oncol. 2019;154(2):388–93.

    Article  PubMed  Google Scholar 

  96. Soliman AM, Taylor H, Bonafede M, Nelson JK, Castelli-Haley J. Incremental direct and indirect cost burden attributed to endometriosis surgeries in the United States. Fertil Steril. 2017;107(5):1181–90.

    Article  PubMed  Google Scholar 

  97. Missmer SA, Cramer DW. Epidemiology of endometriosis. In Endometriosis in clinical practice 2004. CRC Press. p. 79–94.

    Google Scholar 

  98. Guo SW. Recurrence of endometriosis and its control. Hum Reprod Update. 2009;15(4):441–61.

    Article  PubMed  Google Scholar 

  99. Vercellini P, Crosignani PG, Abbiati A, Somigliana E, Vigano P, Fedele L. The effect of surgery for symptomatic endometriosis: the other side of the story. Hum Reprod Update. 2009;15(2):177–88.

    Article  CAS  PubMed  Google Scholar 

  100. Sutton CJ, Ewen SP, Whitelaw N, Haines P. Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. Fertil Steril. 1994;62(4):696–700.

    Article  CAS  PubMed  Google Scholar 

  101. Hornstein MD, Hemmings R, Yuzpe AA, Heinrichs WL. Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. Fertil Steril. 1997;68(5):860–4.

    Article  CAS  PubMed  Google Scholar 

  102. Winkel CA. Evaluation and management of women with endometriosis. Obstet Gynecol. 2003;102(2):397–408.

    PubMed  Google Scholar 

  103. Wellbery C. Diagnosis and treatment of endometriosis. Am Fam Physician. 1999;60(6):1753.

    CAS  PubMed  Google Scholar 

  104. Song JH, Lu H, Zhang J, Li B. Clinical study on the effectiveness and safety of combined laparoscopy and gonadotropin-releasing hormone agonist in the treatment of endometriosis. Zhonghua Fu Chan Ke Za Zhi. 2013;48(8):584–8. Chinese

    CAS  PubMed  Google Scholar 

  105. Alborzi S, Hamedi B, Omidvar A, Dehbashi S, Alborzi S, Alborzi M. A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis. Arch Gynecol Obstet. 2011;284(1):105–10.

    Article  CAS  PubMed  Google Scholar 

  106. Hornstein MD, Yuzpe AA, Burry KA, Heinrichs LR, Buttram VL Jr, Orwoll ES. Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain. Fertil Steril. 1995;63(5):955–62.

    Article  CAS  PubMed  Google Scholar 

  107. Tanmahasamut P, Rattanachaiyanont M, Angsuwathana S, Techatraisak K, Indhavivadhana S, Leerasiri P. Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial. Obstet Gynecol. 2012;119(3):519–26.

    Article  PubMed  Google Scholar 

  108. Chen YJ, Hsu TF, Huang BS, Tsai HW, Chang YH, Wang PH. Postoperative maintenance levonorgestrel-releasing intrauterine system and endometrioma recurrence: a randomized controlled study. Am J Obstet Gynecol. 2017;216(6):582–e1.

    Article  PubMed  Google Scholar 

  109. Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long-term health consequences. Maturitas. 2010;65(2):161–6.

    Article  PubMed  Google Scholar 

  110. Gierach GL, Pfeiffer RM, Patel DA, Black A, Schairer C, Gill A, et al. Long-term overall and disease-specific mortality associated with benign gynecologic surgery performed at different ages. Menopause (New York, NY). 2014;21(6):592.

    Article  Google Scholar 

  111. Faubion SS, Kuhle CL, Shuster LT, Rocca WA. Long-term health consequences of premature or early menopause and considerations for management. Climacteric. 2015;18(4):483–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Duffy JM, Arambage K, Correa FJ, Olive D, Farquhar C, Garry R, et al. Laparoscopic surgery for endometriosis. Cochrane Database Syst Rev. 2014;4:CD011031.

    Google Scholar 

  113. Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012;98(3):591–8.

    Google Scholar 

  114. Parazzini F, Di Cintio E, Chatenoud L, Moroni S, Ardovino I, Struzziero E, et al. Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Hum Reprod. 1999;14(5):1332–4.

    Article  CAS  PubMed  Google Scholar 

  115. Osuga Y, Koga K, Tsutsumi O, Yano T, Maruyama M, Kugu K, et al. Role of laparoscopy in the treatment of endometriosis-associated infertility. Gynecol Obstet Investig. 2002;53(Suppl. 1):33–9.

    Article  Google Scholar 

  116. De Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet. 2010;376(9742):730–8.

    Article  PubMed  Google Scholar 

  117. Steures P, Van Der Steeg JW, Mol BW, Eijkemans MJ, Van Der Veen F, Habbema JD, et al. Prediction of an ongoing pregnancy after intrauterine insemination. Fertil Steril. 2004;82(1):45–51.

    Article  PubMed  Google Scholar 

  118. Eijkemans MJ, Kersten FA, Lintsen AM, Hunault CC, Bouwmans CA, Roijen L, et al. Cost-effectiveness of ‘immediate IVF’versus ‘delayed IVF’: a prospective study. Hum Reprod. 2017;32(5):999–1008.

    Article  CAS  PubMed  Google Scholar 

  119. Benschop L, Farquhar C, van der Poel N, Heineman MJ. Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev. 2010;11:CD008571.

    Google Scholar 

  120. de Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94(7):2796–9.

    Article  PubMed  Google Scholar 

  121. Somigliana E, Vigano P, Benaglia L, Busnelli A, Berlanda N, Vercellini P. Management of endometriosis in the infertile patient. In Seminars in reproductive medicine 2017 (Vol. 35, No. 01, pp. 031-037). Thieme Medical Publishers.

    Google Scholar 

  122. Ferrier C, Boujenah J, Poncelet C, Chabbert-Buffet N, D’Argent EM, Carbillon L, et al. Use of the EFI score in endometriosis-associated infertility: a cost-effectiveness study. Eur J Obstetr Gynecol Reprod Biol. 2020;253:296–303.

    Article  Google Scholar 

  123. Winsor SP, Ala-Leppilampi K, Spitzer K, Edney DR, Petropanagos A, Cadesky KI, et al. The affordability and accessibility of Ontario’s publicly funded IVF program: a survey of patients. J Obstet Gynaecol Can. 2020;42(5):568–75.

    Article  PubMed  Google Scholar 

  124. Collins JA. An international survey of the health economics of IVF and ICSI. Hum Reprod Update. 2002;8(3):265–77.

    Article  PubMed  Google Scholar 

  125. Segel JE. Cost-of-illness studies—a primer. RTI-UNC Center of Excellence in Health Promotion Economics. 2006;1:39.

    Google Scholar 

  126. Kunz K, Kuppermann M, Moynihan C, Williamson A, Mazonson P. The cost of treatment of endometriosis in the California Medicaid population. Am J Managed Care. 1995;1(1):25–9.

    Google Scholar 

  127. Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996;87(3):321–7.

    Article  CAS  PubMed  Google Scholar 

  128. Levy AR, Osenenko KM, Lozano-Ortega G, Sambrook R, Jeddi M, Bélisle S, et al. Economic burden of surgically confirmed endometriosis in Canada. J Obstet Gynaecol Can. 2011;33(8):830–7.

    Article  PubMed  Google Scholar 

  129. Denny E. Women's experience of endometriosis. J Adv Nurs. 2004;46(6):641–8.

    Article  PubMed  Google Scholar 

  130. Sperschneider ML, Hengartner MP, Kohl-Schwartz A, Geraedts K, Rauchfuss M, Woelfler MM, et al. Does endometriosis affect professional life? A matched case-control study in Switzerland, Germany and Austria. BMJ Open. 2019;9(1):e019570.

    Article  PubMed  PubMed Central  Google Scholar 

  131. Estes SJ, Soliman AM, Yang H, Wang J, Freimark J. A longitudinal assessment of the impact of endometriosis on patients’ salary growth and risk of leaving the workforce. Adv Ther. 2020;37(5):2144–58.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Simoens S, Meuleman C, D’Hooghe T. Non-health-care costs associated with endometriosis. Hum Reprod. 2011;26(9):2363–7.

    Article  PubMed  Google Scholar 

  133. Oppelt P, Chavtal R, Haas D, Reichert B, Wagner S, Müller A, et al. Costs of in-patient treatment for endometriosis in Germany 2006: an analysis based on the G-DRG-Coding. Gynecol Endocrinol. 2012;28(11):903–5.

    Article  PubMed  Google Scholar 

  134. Taipale K, Leminen A, Räsänen P, Heikkilä A, Tapper AM, Sintonen H, et al. Costs and health-related quality of life effects of hysterectomy in patients with benign uterine disorders. Acta Obstet Gynecol Scand. 2009;88(12):1402–10.

    Article  PubMed  Google Scholar 

  135. Klein S, D’Hooghe T, Meuleman C, Dirksen C, Dunselman G, Simoens S. What is the societal burden of endometriosis-associated symptoms? A prospective Belgian study. Reprod Biomed Online. 2014;28(1):116–24.

    Article  PubMed  Google Scholar 

  136. Vercellini P, Giudice LC, Evers JL, Abrao MS. Reducing low-value care in endometriosis between limited evidence and unresolved issues: a proposal. Hum Reprod. 2015;30(9):1996–2004.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Schulich School of Medicine & Dentistry, Western University, London, ON, Canada

    Brintha Sivajohan

  2. Department of Obstetrics and Gynecology, The University of British Columbia, Vancouver, BC, Canada

    Tinya Lin

  3. Department of Obstetrics and Gynaecology, BC Women’s Hospital and Health Center, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada

    Mohamed A. Bedaiwy

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  1. Brintha Sivajohan
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  3. Mohamed A. Bedaiwy
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Correspondence to Mohamed A. Bedaiwy .

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  1. Department of Obstetrics and Gynecology, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey

    Engin Oral

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Sivajohan, B., Lin, T., Bedaiwy, M.A. (2022). Cost Estimates Associated with Diagnosis and Treatment of Endometriosis. In: Oral, E. (eds) Endometriosis and Adenomyosis. Springer, Cham. https://doi.org/10.1007/978-3-030-97236-3_28

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