Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease that costs a growing burden on patients, family members, healthcare systems, and society worldwide. Currently, none of the approaches can slow down or stop the damage and destruction of neurons or the progression of the disease. Acupuncture is a unique non-pharmacologic therapy. In recent years, there has been increasing evidence that acupuncture may be an effective and safe way to treat AD. In this chapter, we summarize the acupuncture treatment for AD from the aspects of clinical research and mechanism. In the future, we need more high-quality evidence to confirm the effectiveness and to further explore its mechanism.
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Abbreviations
- AD:
-
Alzheimer’s disease
- Aβ:
-
amyloid β
- ADAS-cog:
-
Alzheimer’s Disease Assessment Scale-cognitive section
- ADL:
-
activities of daily living
- BDNF:
-
brain-derived neurotrophic factor
- fMRI:
-
functional magnetic resonance imaging
- GFAP:
-
glial fibrillary acidic protein
- GRADE:
-
Grading of Recommendation, Assessment, Development, and Evaluation
- HPO:
-
hypothalamus-pituitary-ovary
- MMSE:
-
Mini-Mental State Examination
- NDRG2:
-
N-myc downstream-regulated gene 2
- RCTs:
-
randomized controlled trials
- SAMP8:
-
senescence accelerated mouse P8
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Acknowledgments
This study was supported by the Key Scientific Research Program of the Shanghai Municipal Science and Technology Committee in China (16401970300 and 18401970500), the financing scheme of Arising Interdisciplinary Subjects of TCM in Shanghai (Shxxjcxk201709), and the TCM Genre Program of Shanghai Health Bureau (ZY (2018-2020)-CCCX-1006).
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Pei, J. (2022). Acupuncture Treatment for Alzheimer’s Disease. In: Xia, Y. (eds) Advanced Acupuncture Research: From Bench to Bedside. Springer, Cham. https://doi.org/10.1007/978-3-030-96221-0_24
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