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Exercise-Regulated Skeletal Muscle Glucose Uptake

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Exercise Metabolism

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Abstract

Muscle glucose uptake during exercise is regulated by a coordinated increase in glucose delivery (via increased blood flow and glucose moving out of the capillaries into the interstitial space), by facilitated glucose transport into the myocytes and by intramyocellular metabolism. The facilitative glucose transporter GLUT4 is translocated to the sarcolemma and the t-tubules, and GLUT4 translocation is essential for glucose transport into the myocytes during exercise. Several molecular mechanisms have been proposed to regulate insulin-independent GLUT4 translocation during in vivo conditions, but the regulation of both exercise-stimulated GLUT4 translocation and the integrative glucose uptake process by exercise remains incompletely understood. GLUT4 intrinsic transporter activity may also be regulated during exercise although there is no firm evidence for this. The multitude of mechanisms involved in muscle glucose uptake stimulation during exercise ensure the delivery of easily combustible fuel to the working muscles.

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Funding

This work was supported by grants from the Novo Nordisk foundation, the Independent Research Fund Denmark, and/or the Lundbeck foundation to LSH, TEJ, GKM, and EAR and the Danish Diabetes Academy funded by the Novo Nordisk Foundation to COL, JRK, and GKM.

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  1. “Thomas E. Jensen” and “Erik A. Richter” are co-corresponding authors.

Authors and Affiliations

  1. August Krogh Section for Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark

    Thomas E. Jensen, Jonas R. Knudsen, Carlos Henriquez-Olguin, Lykke Sylow & Erik A. Richter

  2. Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia

    Glenn McConell

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  1. Thomas E. Jensen
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  2. Jonas R. Knudsen
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  3. Carlos Henriquez-Olguin
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  4. Lykke Sylow
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  6. Erik A. Richter
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Correspondence to Thomas E. Jensen or Erik A. Richter .

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  1. Victoria University, Melbourne, VIC, Australia

    Glenn McConell

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Jensen, T.E., Knudsen, J.R., Henriquez-Olguin, C., Sylow, L., McConell, G., Richter, E.A. (2022). Exercise-Regulated Skeletal Muscle Glucose Uptake. In: McConell, G. (eds) Exercise Metabolism. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-94305-9_6

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