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Treatment of Blepharospasm with Botulinum Toxin

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Foundational Papers in Oculoplastics
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Abstract

Botulinum toxin therapy has been a life-changing treatment for patients with facial dystonias. The following articles describe an initial experience with as well as a long-term follow-up of botulinum toxin treatment for these conditions with excellent early and long-term results.

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References

  1. Schantz EJ, Johnson EA (1997) Botulinum toxin: the story of its development for the treatment of human disease. Perspect Biol Med 40:317–327

    Article  CAS  Google Scholar 

  2. Scott AB (1980) Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology 87:1044–1049

    Article  CAS  Google Scholar 

  3. Frueh BR, Felt DP, Wojno THMD (1984) Treatment of blepharospasm with botulinum toxin. Arch Ophthalmol 102:1464

    Article  CAS  Google Scholar 

  4. Scott AB, Kennedy RA, Stubbs HA (1985) Botulinum A toxin injection as a treatment for blepharospasm. Arch Ophthalmol 103:347–350

    Article  CAS  Google Scholar 

  5. Czyz CN, Burns JA, Petrie TP, Watkins JR, Cahill KV, Foster JA (2013) Long-term botulinum toxin treatment of benign essential blepharospasm, hemifacial spasm, and Meige syndrome. Am J Ophthalmol 156:173–177.e2

    Article  CAS  Google Scholar 

  6. Marsden CD (1976) Blepharospasm-oromandibular dystonia syndrome (Brueghel’s syndrome). A variant of adult-onset torsion dystonia? J Neurol Neurosurg Psychiatry 39:1204–1209

    Article  CAS  Google Scholar 

  7. Anderson RL, Patel BCK, Holds JB, Jordan DR (1998) Blepharospasm: past, present, and future. Ophthal Plast Reconstr Surg 14:305–317

    Article  CAS  Google Scholar 

  8. Carruthers JDA, Carruthers JA (1992) Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol 18:17–21

    Article  CAS  Google Scholar 

  9. Maasumi K, Thompson NR, Kriegler JS, Tepper SJ (2015) Effect of onabotulinumtoxinA injection on depression in chronic migraine. Headache 55:1218–1224

    Article  Google Scholar 

  10. Stearns TP, Shad MU, Guzman GC (2018) Glabellar botulinum toxin injections in major depressive disorder. Prim Care Companion CNS Disord 20:1–8

    Article  Google Scholar 

  11. Zamanian A, Ghanbari Jolfaei A, Mehran G, Azizian Z (2017) Efficacy of botox versus placebo for treatment of patients with major depression. Iran J Public Health 46:982–984

    PubMed  PubMed Central  Google Scholar 

  12. Dressler D, Karapantzou C, Rohrbach S, Schneider S, Laskawi R (2017) Frontalis suspension surgery to treat patients with blepharospasm and eyelid opening apraxia: long-term results. J Neural Transm 124:253–257

    Article  Google Scholar 

  13. Brandt F, Swanson N, Baumann L, Huber B (2009) Randomized, placebo-controlled study of a new botulinum toxin type a for treatment of glabellar lines: efficacy and safety. Dermatologic Surg 35:1893–1901

    Article  CAS  Google Scholar 

  14. Steinsapir KD, Rootman D, Wulc A, Hwang C (2015) Cosmetic microdroplet botulinum toxin A forehead lift. Ophthal Plast Reconstr Surg 31:263–268

    Article  Google Scholar 

  15. Evinger C (2015) Benign essential blepharospasm is a disorder of neuroplasticity: lessons from animal models. J Neuroophthalmol 35:374–379

    Article  Google Scholar 

  16. Namiguchi K, Mizoue S, Ohta K, Shiraishi A (2018) Effect of botulinum toxin A treatment on eyelid pressure in eyes with blepharospasm. Curr Eye Res 43:896–901

    Article  CAS  Google Scholar 

  17. Gil Polo C, Rodríguez Sanz MF, Berrocal Izquierdo N, Castrillo Sanz A, Gutiérrez Ríos R, Zamora García MI, Mendoza Rodríguez A, Duarte García-Luis J (2013) Blefarospasmo y espasmo hemifacial: tratamiento a largo plazo con toxina botulínica. Neurologia 28:131–136

    Article  CAS  Google Scholar 

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Ramesh, S. (2022). Treatment of Blepharospasm with Botulinum Toxin. In: Foundational Papers in Oculoplastics . Springer, Cham. https://doi.org/10.1007/978-3-030-92794-3_16

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  • DOI: https://doi.org/10.1007/978-3-030-92794-3_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-92793-6

  • Online ISBN: 978-3-030-92794-3

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