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Depression in Pregnancy: Biological, Clinical, and Psychosocial Effects

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Key Topics in Perinatal Mental Health

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Abstract

Depression during pregnancy (antenatal depression) affects up to 20% of expectant mothers, yet is not as widely studied as postnatal depression. Research has begun to identify that antenatal depression can carry long-lasting biological, clinical, and psychosocial implications for not only mothers, but for their babies as well. Furthermore, these outcomes can alter infant development through to adulthood. Women depressed in pregnancy (and their babies) are more likely to have alterations in their biological systems, including their hypothalamic–pituitary–adrenal (HPA) axes and immune systems; they are more likely to continue to be unwell beyond the antenatal period and are at heightened risk for poor clinical outcomes; their offspring are more likely to develop psychopathology themselves which can last through adulthood; they are less likely to feel emotionally and physically supported; and, finally, are more likely to experience difficulties interacting with their babies. It is thus of the utmost importance that women with depressive symptoms in pregnancy be identified and treated, to not only support mothers but to optimise their babies’ development as well.

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Authors and Affiliations

  1. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Rebecca H. Bind, Kristi Sawyer & Carmine Pariante

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  1. Rebecca H. Bind
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  2. Kristi Sawyer
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  3. Carmine Pariante
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Correspondence to Carmine Pariante .

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Editors and Affiliations

  1. Department of Mental Health and Addiction Services, Niguarda Hospital, Milan, Italy

    Mauro Percudani

  2. Policentro Donna Ambulatory, Italian Marcé Society, Milan, Italy

    Alessandra Bramante

  3. Department of Mental Health and Addiction Services, Niguarda Hospital, Italian Marcé Society, Milan, Italy

    Valeria Brenna

  4. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Carmine Pariante

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Bind, R.H., Sawyer, K., Pariante, C. (2022). Depression in Pregnancy: Biological, Clinical, and Psychosocial Effects. In: Percudani, M., Bramante, A., Brenna, V., Pariante, C. (eds) Key Topics in Perinatal Mental Health. Springer, Cham. https://doi.org/10.1007/978-3-030-91832-3_1

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  • DOI: https://doi.org/10.1007/978-3-030-91832-3_1

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