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Fetal Origin of Adult Disease: The Case of GDM

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Comprehensive Clinical Approach to Diabetes During Pregnancy

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Abstract

Gestational diabetes mellitus (GDM) is a common condition affecting many women worldwide. In addition to the well-known complications during pregnancy and at birth, recent studies have linked GDM to risk for long-term disease in offspring, including impaired glucose tolerance and obesity. Investigations of the mechanisms by which GDM may “program” the exposed offspring to a higher risk of cardiometabolic disease later in life have suggested epigenetic mechanisms affecting gene methylation, hormonal alterations, and hypothalamic changes. Identifying such mechanisms will allow targeted intervention in pregnancy and childhood to prevent the development of long-term adult disease.

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  1. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Maria I. Stamou & Marie-France Hivert

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  1. Maria I. Stamou
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  1. Unit of Reproductive Endocrinology, 1st Department of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Dimitrios G. Goulis

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Stamou, M.I., Hivert, MF. (2022). Fetal Origin of Adult Disease: The Case of GDM. In: Goulis, D.G. (eds) Comprehensive Clinical Approach to Diabetes During Pregnancy. Springer, Cham. https://doi.org/10.1007/978-3-030-89243-2_6

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