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Perioperative Care in Older Adults with Cancer and Frailty

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Frailty in Older Adults with Cancer
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Abstract

Current projections indicate that by 2030, one-fifth of people in England aged above the age of 75 years and older will undergo surgery each year. Many will undergo cancer surgery and a significant proportion will have frailty. Studies consistently show that pre-existing frailty is associated with higher complication and all-cause mortality rates in surgical patients. This has led to the development of the POPS (perioperative care of older people undergoing surgery) model of care which underpins a paradigm shift in the way surgery in the elderly is managed. POPS encompasses care from preoperative assessment, through surgery to discharge and beyond. The main pillar of POPS is the delivery of perioperative care based on comprehensive geriatric assessment. Elective surgery assessment generally takes place in multidisciplinary pre-assessment clinics with the involvement of anaesthetists, surgeons, geriatricians, nurses and allied healthcare professionals. Preoperative assessment provides the basis for preoperative optimisation of physiological reserve, comorbidities, geriatric syndromes, as well as the planning of postoperative optimisation. Ward-based components of the proactive care of POPS encompass all aspects of the postoperative assessment and optimisation of an older person with frailty who has undergone emergency or elective surgery, including discharge planning. This chapter will discuss the implications of frailty, risk stratification, relevant investigations, as well as the multidisciplinary perioperative care required to manage the older adult with frailty undergoing cancer surgery.

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References

  1. ONU. World population prospects 2019 [Internet]. Department of Economic and Social Affairs. World Population Prospects 2019. Available from http://www.ncbi.nlm.nih.gov/pubmed/12283219

  2. Fowler AJ, Abbott TE, Prowle RPR. Age of patients undergoing surgery. Br J Surg. 2019;106(8):1012–8.

    Article  CAS  PubMed  Google Scholar 

  3. Clegg A, Young J, Iliffe S, Olde Rikkert MGM, Rockwood K. Frailty in older people summary. Lancet. 2013;381(9868):752–62.

    Article  PubMed  Google Scholar 

  4. Hewitt J, Long S, Carter B, Bach S, McCarthy K, Clegg A. The prevalence of frailty and its association with clinical outcomes in general surgery: a systematic review and meta-analysis. Age Ageing. 2018;47(6):793–800.

    Article  PubMed  Google Scholar 

  5. Hale M, Shah S, Clegg A. Frailty, inequality and resilience. Clin Med (Lond). 2019;19(3):219–23.

    Article  Google Scholar 

  6. Rockwood K, Minitski A. Limits to deficint accumulation in elderly people. Mech Ageing Dev. 2006;127(5):494–6.

    Article  PubMed  Google Scholar 

  7. Hollinghurst J, Fry R, Akbari A, Clegg A, Lyons RA, Watkins A, et al. External validation of the electronic frailty index using the population of Wales within the secure anonymised information linkage databank. Age Ageing. 2019;48(6):922–6.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Panayi AC, Orkaby AR, Sakthivel D, Endo Y, Varon D, Roh D, et al. Impact of frailty on outcomes in surgical patients: a systematic review and meta-analysis. Am J Surg. 2019;218(2):393–400.

    Article  CAS  PubMed  Google Scholar 

  9. Shahrokni A, Tin A, Korc-Grodzicki B. Development and evaluation of a new frailty index for older surgical patients with cancer. JAMA Netw Open. 2019;2(5):e193545.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kow AW. Prehabilitation and its role in geriatric surgery. Ann Acad Med Singap. 2019;48(11):386–92.

    Article  PubMed  Google Scholar 

  11. Ethun CG, Bilen MA, Jani AB, Maithel SK, Ogan K, Master VA. Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology. CA Cancer J Clin. 2017;67(5):362–77.

    Article  PubMed  Google Scholar 

  12. Strøm C, Rasmussen LSSJ. Practical management of anaesthesia in the elderly. Drugs Aging. 2016;33(11):765–77.

    Article  PubMed  Google Scholar 

  13. Pilka R, Marek R, Adam T, Kudela M, Ondrová D, Neubert D, et al. Systemic inflammatory response after open, laparoscopic and robotic surgery in endometrial cancer patients. Anticancer Res. 2016;36(6):2909–22.

    CAS  PubMed  Google Scholar 

  14. Gould TH, Grace K, Thorne GTM. Effect of thoracic epidural anaesthesia on colonic blood flow. Br J Anaesth. 2002;89(3):446–51.

    Article  CAS  PubMed  Google Scholar 

  15. McEvoy M, Gupta R, Koepke E, Feldheiser A, Michard F, et al. Perioperative Quality Initiative (POQI)-3 consensus statement on postoperative blood pressure: risk and outcomes for elective surgery. Br J Anaesth. 2019;122(5):563–74.

    Article  Google Scholar 

  16. Sessler DI, Pei L, Huang Y, Fleischmann E, Marhofer P, Kurz A, et al. Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet. 2019;394(10211):1807–15.

    Article  PubMed  Google Scholar 

  17. Hughes SG. Prescribing for the elderly patient: why do we need to exercise caution? Br J Clin Pharmacol. 1998;46(6):531–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Mangoni AA, Jackson SHD. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Strøm C, Rasmussen LS, Steinmetz J. Practical management of anaesthesia in the elderly. Drugs Aging. 2016;33(11):765–77.

    Article  PubMed  Google Scholar 

  20. May SM, Abbott TEF, Del Arroyo AG, Reyes A, Martir G, Stephens RCM, et al. MicroRNA signatures of perioperative myocardial injury after elective noncardiac surgery: prospective observational mechanistic cohort study. Br J Anaesth. 2020;125(5):661–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Alam A, Hana Z, Jin Z, Suen KCMD. Surgery, neuroinflammation and cognitive impairment. EBioMedicine. 2018;37:547–56.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Buggy DJWT. Can anaesthetic-analgesic technique during cancer surgery of curative intent influence recurrence or metastasis? An update. Br J Anaesth. 2019;126(6):e525–6.

    Article  Google Scholar 

  23. Lane-Fall M. Outcomes measures and risk adjustment. Int Anesthesiol Clin. 2013;51(4):10. https://doi.org/10.1097/AIA.0b013e3182a70a52.

    Article  PubMed  PubMed Central  Google Scholar 

  24. NHS. New care models risk stratification: learning and impact study, 2017.

    Google Scholar 

  25. Dera D. Risk stratification: a two-step process for identifying your sickest patients. Am Acad Fam Phys. 2019.

    Google Scholar 

  26. Protopapa KL, Simpson JC, Smith NCE, Moonesinghe SR. Development and validation of the surgical outcome risk tool (SORT). Br J Surg. 2014;101(13):1774–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Hornor MA, Ma M, Zhou L, Cohen ME, Rosenthal RA, Russell MM, et al. Enhancing the American College of Surgeons NSQIP surgical risk calculator to predict geriatric outcomes. J Am Coll Surg. 2020;230(1):88–100.e1. https://doi.org/10.1016/j.jamcollsurg.2019.09.017.

    Article  PubMed  Google Scholar 

  28. Eamer G, Al-Amoodi MJH, Holroyd-Leduc J, Rolfson DB, Warkentin LM, Khadaroo RG. Review of risk assessment tools to predict morbidity and mortality in elderly surgical patients. Am J Surg. 2018;216(3):585–94. https://doi.org/10.1016/j.amjsurg.2018.04.006.

    Article  PubMed  Google Scholar 

  29. Kim S, Brooks AK, LG. Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Clin Interv Aging. 2015;10:13–27.

    PubMed  Google Scholar 

  30. Kumar A, Srinivastava U. Role of routine laboratory investigations in preoperative evaluation. J Anaesthesiol Clin Pharmacol. 2011;27(2):174–9.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Croal BL, et al. Measurement of exercise tolerance before surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery. BMJ Open. 2016;6(3):e010359.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Wijeysundera DN, Pearse RM, Shulman MA, Abbott TEF, Torres E, Ambosta A, et al. Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. Lancet. 2018;391(10140):2631–40.

    Article  PubMed  Google Scholar 

  33. Carli F, Baldini GFL. Redesigning the preoperative clinic. JAMA Surg. 2021;156(2):191–2.

    Article  PubMed  Google Scholar 

  34. Partridge JSL, Harari D, Martin FC, Peacock JL, Bell R, Mohammed A, et al. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery. Br J Surg. 2017;104(6):679–87.

    Article  CAS  PubMed  Google Scholar 

  35. Deshpande R, Asch WS, Malinis M. Frailty and perioperative outcomes. Curr Anesthesiol Rep. 2018;8(2):225–31.

    Article  Google Scholar 

  36. Rocha V, Marmelo F, Leite-Moreira A, Moreira-Gonçalves D. Clinical utility of frailty scales for the prediction of postoperative complications: systematic review and meta-analysis. Rev Port Cir Cardiotorac Vasc. 2017;24(3–4):132.

    PubMed  Google Scholar 

  37. Rolfson DB, Majumdar SR, Tsuyuki RT, Adeel Tahir KR. Validity and reliability of the Edmonton frail scale. Age Ageing. 2006;35(5):526–9.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Clegg A, Young J, Iliffe S. Marcel Olde Rikkert and KR. Frailty in elderly people. Lancet. 2013;381(9868):752–62.

    Article  PubMed  Google Scholar 

  39. Mcisaac DI, Harris EP, Hladkowicz E, Moloo H, Lalu MM, Bryson GL, et al. Prospective comparison of preoperative predictive performance between 3 leading frailty instruments. Anesth Analg. 2020;131(1):263–72.

    Article  PubMed  Google Scholar 

  40. The British Geriatrics Society. Fit for frailty: consensus best practice guidance for the care of older people living with frailty in community and outpatient settings. 2014;26 p.

    Google Scholar 

  41. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.

    Article  PubMed  PubMed Central  Google Scholar 

  42. McIsaac DI, Macdonald DB, Aucoin SD. Frailty for perioperative clinicians: a narrative review. Anesth Analg. 2020;130(6):1450–60.

    Article  PubMed  Google Scholar 

  43. Faller JW, do Nascimento Pereira D, de Souza S, Nampo FK, de Souza Orlandi F, Matumoto S. Instruments for the detection of frailty syndrome in older adults: a systematic review. PLoS One. 2019;14(4):1–23.

    Article  Google Scholar 

  44. Levy N, Grocott MPW, Carli F. Patient optimisation before surgery: a clear and present challenge in peri-operative care. Anaesthesia. 2019;74:3–6.

    Article  PubMed  Google Scholar 

  45. Gordon AL, Evans BJ, Dhesi J. The physician’s role in perioperative management of older patients undergoing surgery. Clin Med (Lond). 2017;17(4):357–9.

    Article  Google Scholar 

  46. Milder DA, Pillinger NL, Kam PCA. The role of prehabilitation in frail surgical patients: a systematic review. Acta Anaesthesiol Scand. 2018;62(10):1356–66.

    Article  PubMed  Google Scholar 

  47. Chan SP, Ip KY, Irwin MG. Peri-operative optimisation of elderly and frail patients: a narrative review. Anaesthesia. 2019;74(1):80–9.

    Article  PubMed  Google Scholar 

  48. Cheung JTK, Yu R, Wu Z, Wong SYS, Woo J. Geriatric syndromes, multimorbidity, and disability overlap and increase healthcare use among older Chinese. BMC Geriatr. 2018;18(1):1–8.

    Article  Google Scholar 

  49. Welch C, Hassan-Smith ZK, Greig CA, Lord JM, Jackson TA. Acute sarcopenia secondary to hospitalisation - an emerging condition affecting older adults. Aging Dis. 2018;9(1):151–64.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Mohd Nawi SN, Khow KS, Lim WS, Yu SC. Screening tools for sarcopenia in community-dwellers: a scoping review. Ann Acad Med Singap. 2019;48(7):201–16.

    Article  PubMed  Google Scholar 

  51. Dolan DR, Knight KA, Maguire S, Moug SJ. The relationship between sarcopenia and survival at 1 year in patients having elective colorectal cancer surgery. Tech Coloproctol. 2019;23(9):877–85. https://doi.org/10.1007/s10151-019-02072-0.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Kuwada K, Kuroda S, Kikuchi S, Yoshida R, Nishizaki M, Kagawa S, et al. Sarcopenia and comorbidity in gastric cancer surgery as a useful combined factor to predict eventual death from other causes. Ann Surg Oncol. 2018;25(5):1160–6. https://doi.org/10.1245/s10434-018-6354-4.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31.

    Article  PubMed  Google Scholar 

  54. Martone AM, Marzetti E, Calvani R, Picca A, Tosato M, Bernabei R, et al. Assessment of sarcopenia: from clinical practice to research. J Gerontol Geriatr. 2019;67(1):39–45.

    Google Scholar 

  55. Han A, Bokshan S, Marcaccio S, DePasse J, Daniels A. Diagnostic criteria and clinical outcomes in sarcopenia research: a literature review. J Clin Med. 2018;7(4):70.

    Article  PubMed Central  Google Scholar 

  56. Robinson SM, Reginster JY, Rizzoli R, Shaw SC, Kanis JA, Bautmans I, et al. Does nutrition play a role in the prevention and management of sarcopenia? Clin Nutr. 2018;37(4):1121–32.

    Article  CAS  PubMed  Google Scholar 

  57. Malafarina V, Reginster JY, Cabrerizo S, Bruyère O, Kanis JA, Alfredo Martinez J, et al. Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture. Nutrients. 2018;10(5):1–26.

    Article  Google Scholar 

  58. Ohkura Y, Haruta S, Tanaka T, Ueno M, Udagawa H. Effectiveness of postoperative elemental diet (Elental®) in elderly patients after gastrectomy. World J Surg Oncol [Internet]. 2016;14(1):1–6. https://doi.org/10.1186/s12957-016-1013-3.

    Article  Google Scholar 

  59. Benton K, Thomson I, Isenring E, Mark Smithers B, Agarwal E. An investigation into the nutritional status of patients receiving an enhanced recovery after surgery (ERAS) protocol versus standard care following oesophagectomy. Support Care Cancer. 2018;26(6):2057–62.

    Article  PubMed  Google Scholar 

  60. Roberts HC, Lim SER, Cox NJ, Ibrahim K. The challenge of managing undernutrition in older people with frailty. Nutrients. 2019;11(4):1–17.

    Article  Google Scholar 

  61. Volkert D, Beck AM, Cederholm T, Cruz-Jentoft A, Goisser S, Hooper L, et al. ESPEN guideline on clinical nutrition and hydration in geriatrics. Clin Nutr. 2019;38(1):10–47. https://doi.org/10.1016/j.clnu.2018.05.024.

    Article  PubMed  Google Scholar 

  62. Vlisides P, Avidan M. Recent advances in preventing and managing postoperative delirium. F1000Res. 2019;8:1–10.

    Article  Google Scholar 

  63. Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium. Eur J Anaesthesiol. 2017;34(4):192–214.

    Article  PubMed  Google Scholar 

  64. Mosk CA, van Vugt JLA, de Jonge H, Witjes CDM, Buettner S, Ijzermans JNM, et al. Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. Clin Interv Aging. 2018;13:2097–106.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Hempenius L, Slaets JPJ, van Asselt DZB, Schukking J, de Bock GH, T., van Wiggers BL. Interventions to prevent postoperative delirium in elderly cancer patients should be targeted at those undergoing nonsuperficial surgery with special attention to the cognitive impaired patients. Eur J Surg Oncol. 2015;41(1):28–33.

    Article  CAS  PubMed  Google Scholar 

  66. Evered LA, Silbert BS. Postoperative cognitive dysfunction and noncardiac surgery. Anesth Analg. 2018;127(2):496–505.

    Article  PubMed  Google Scholar 

  67. Mrkobrada M, Chan MTV, Cowan D, Campbell D, Wang CY, Torres D, et al. Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet. 2019;394(10203):1022–9.

    Article  Google Scholar 

  68. Nair S, Oliver D, Cracknell A. Meeting the needs of older patients. [Internet]. In J North (Author), M McKee, S Merkur, N Edwards, E Nolte (Eds), The changing role of the hospital in European Health Systems (European Observatory on Health Systems and PoliciesACN Bold Voices. Cambridge: Cambridge University Press; 2020. 85–119 p. Available from: http://search.ebscohost.com/login.aspx?direct=true&db=c8h&AN=119171688&lang=pt-br&site=ehost-live

  69. England N. Hospital discharge service: Policy Operating Model. 2020.

    Google Scholar 

  70. Harari D, Hopper A, Dhesi J, Babic-Illman G, Lockwood L, Martin F. Proactive care of older people undergoing surgery (‘POPS’): designing, embedding, evaluating and funding a comprehensive geriatric assessment service for older elective surgical patients. Age Ageing. 2007;36(2):190–6.

    Article  PubMed  Google Scholar 

  71. Partridge J, Sbai M, Dhesi J. Proactive care of older people undergoing surgery. Aging Clin Exp Res. 2018;30(3):253–7. https://doi.org/10.1007/s40520-017-0879-4.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Braude P, Goodman A, Elias T, Babic-Illman G, Challacombe B, Harari D, et al. Evaluation and establishment of a ward-based geriatric liaison service for older urological surgical patients: proactive care of older people undergoing surgery (POPS)-urology. BJU Int. 2017;120(1):123–9.

    Article  PubMed  Google Scholar 

  73. Partridge JSL, Collingridge G, Gordon AL, Martin FC, Harari D, Dhesi JK. Where are we in perioperative medicine for older surgical patients? A UK survey of geriatric medicine delivered services in surgery. Age Ageing. 2014;43(5):721–4.

    Article  PubMed  Google Scholar 

  74. Dhesi JK, Swart M. Specialist pre-operative assessment clinics. Anaesthesia. 2016;71:3–8.

    Article  PubMed  Google Scholar 

  75. Durrand J, Singh SJ, Danjoux G. CMJv19n6-Durrand.indd. Clin Med (Northfield, IL). 2017;17(6):458–64.

    Article  Google Scholar 

  76. Dhesi J. Setting up a proactive service to make surgery safer for older people. 2013;1–6.

    Google Scholar 

  77. Rogerson A, Partridge JS, Dhesi JK. Perioperative medicine for older people. Ann Acad Med Singap. 2019;48(11):376–81.

    Article  PubMed  Google Scholar 

  78. Partridge JSL, Harari D, Martin FC, Dhesi JK. The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia. 2014;69(suppl 1):8–16.

    Article  PubMed  Google Scholar 

  79. Pędziwiatr M, Mavrikis J, Witowski J, Adamos A, Major P, Nowakowski M, et al. Current status of enhanced recovery after surgery (ERAS) protocol in gastrointestinal surgery. Med Oncol. 2018;35(6):1–8. https://doi.org/10.1007/s12032-018-1153-0.

    Article  Google Scholar 

  80. Melnyk M, Casey RG, Black P, Koupparis AJ. Enhanced recovery after surgery (eras) protocols: time to change practice? J Can Urol Assoc. 2011;5(5):342–8.

    Article  Google Scholar 

  81. Paton F, Chambers D, Wilson P, Eastwood A, Craig D, Fox D, et al. Effectiveness and implementation of enhanced recovery after surgery programmes: a rapid evidence synthesis. BMJ Open. 2014;4(7):e005015.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Jones C, Kelliher L. Enhanced recovery after surgery: past, present and future. Dig Med Res. 2019;2:19.

    Article  Google Scholar 

  83. Bettelli G, Maggi S. Decision-making about surgery in the elderly. Aging Clin Exp Res. 2018;30(3):225–7. https://doi.org/10.1007/s40520-018-0915-z.

    Article  PubMed  Google Scholar 

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Nair, S., Howell, S.J. (2022). Perioperative Care in Older Adults with Cancer and Frailty. In: Gomes, F. (eds) Frailty in Older Adults with Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-89162-6_13

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