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How Safe is Plasma Treatment in Clinical Applications?

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Textbook of Good Clinical Practice in Cold Plasma Therapy

Abstract

The principal aim of this chapter is to provide a comprehensive overview of safety aspects and potential health risks in humans related to the exposure to cold physical plasma. Numerous studies were concerned with these critical aspects, as it is pivotal for the general acceptance of cold physical plasma among biologists, physicists, physicians, and patients. The chapter consists of five sections. It starts with an introduction to risk management, describing fundamentals in the risk assessment process and standardization. The next section summarizes the basics of cold physical plasma use and a description of sources, components, and biological effectors. The critical parameters of the multi-component plasma system are discussed, which are likely to be effective, but also potentially hazardous in their application to biological tissue. The next part covers risk estimations of plasma applications, a comprehensive analysis of studies assessing the preclinical and clinical relevance, and an analysis of the reliability of utilizing plasma treatment in clinical trials. A majority of studies pointed to a lack of mutagenic- and genotoxic-related effects along with beneficial effects in chronic wound healing, decontamination, and the killing of microorganisms and tumor cells. The last paragraph addresses the perspectives and limitations of plasma use in clinical plasma medicine.

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    1. ZIK Plasmatis, Leibniz-Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany

      Anke Schmidt & Sander Bekeschus

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      Hans-Robert Metelmann

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      Thomas von Woedtke

    3. Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany

      Klaus-Dieter Weltmann

    4. University Medical Center Rostock, Rostock, Germany

      Steffen Emmert

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    Schmidt, A., Bekeschus, S. (2022). How Safe is Plasma Treatment in Clinical Applications?. In: Metelmann, HR., von Woedtke, T., Weltmann, KD., Emmert, S. (eds) Textbook of Good Clinical Practice in Cold Plasma Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-87857-3_5

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