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Allogeneic Immunity Following Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes

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Advanced Technologies in Cardiovascular Bioengineering

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Abstract

Accumulating evidence suggests that transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) can regenerate the injured heart, which has triggered a wave of clinical trials. Since most preclinical studies were performed in xenogeneic transplantation models, little is known on post-transplant immunity in allogeneic models, as is the case in clinics. The current immunosuppressant protocols following hPSC-CM transplantation in clinical trials are equivalent to those following heart transplantation; however, the optimal protocol for cell transplantation may differ. In this chapter, I will describe the recent efforts to optimize immunosuppressant protocols via allogeneic transplantation models in non-human primates as well as novel approaches to reduce the amount of immunosuppressants.

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Authors and Affiliations

  1. Department of Regenerative Science and Medicine, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan

    Yuji Shiba

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  1. Yuji Shiba
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Correspondence to Yuji Shiba .

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  1. Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA

    Jianyi Zhang

  2. Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Vahid Serpooshan

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Shiba, Y. (2022). Allogeneic Immunity Following Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes. In: Zhang, J., Serpooshan, V. (eds) Advanced Technologies in Cardiovascular Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-030-86140-7_5

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  • DOI: https://doi.org/10.1007/978-3-030-86140-7_5

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