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Risk Factors for Breast Cancer

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Modern Breast Cancer Imaging

Abstract

Breast cancer is the second most common malignancy globally after lung cancer, and it is the most frequent cancer among women. Its incidence has been increasing in recent decades, and due to this relevant social, medical, and epidemiological impact, it is important to understand what are the risk factors involved in its development and what can be done to reduce the risk of having this neoplasm.

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References

  1. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53.

    Article  CAS  PubMed  Google Scholar 

  2. Sung H, Ferlay J, Siegel RL, Laversanne M, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;0:1–41.

    Google Scholar 

  3. INCA INdC-. Câncer de mama 2020. Available at: https://www.inca.gov.br/tipos-de-cancer/cancer-de-mama.

  4. Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer (Dove Med Press). 2019;11:151–64.

    Google Scholar 

  5. Tamimi RM, Spiegelman D, Smith-Warner SA, Wang M, Pazaris M, Willett WC, et al. Population attributable risk of modifiable and nonmodifiable breast cancer risk factors in postmenopausal breast cancer. Am J Epidemiol. 2016;184(12):884–93.

    Article  PubMed  PubMed Central  Google Scholar 

  6. DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin. 2014;64(1):52–62.

    Article  PubMed  Google Scholar 

  7. UK CR. Breast cancer risk Internet 2020. Available at: https://www.cancerresearchuk.org/health-professional/cancerstatistics/statistics-by-cancer-type/breast-cancer/incidence-invasive#heading-One.

  8. Smart CR, Hendrick RE, Rutledge JH, Smith RA. Benefit of mammography screening in women ages 40 to 49 years. Current evidence from randomized controlled trials. Cancer. 1995;75(7):1619–26.

    Article  CAS  PubMed  Google Scholar 

  9. Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomark Prev. 2004;13(10):1558–68.

    Article  CAS  Google Scholar 

  10. Thakur P, Seam RK, Gupta MK, Gupta M, Sharma M, Fotedar V. Breast cancer risk factor evaluation in a Western Himalayan state: a case-control study and comparison with the Western World. South Asian J Cancer. 2017;6(3):106–9.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Huo D, Adebamowo CA, Ogundiran TO, Akang EE, Campbell O, Adenipekun A, et al. Parity and breastfeeding are protective against breast cancer in Nigerian women. Br J Cancer. 2008;98(5):992–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ma H, Bernstein L, Pike MC, Ursin G. Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies. Breast Cancer Res. 2006;8(4):R43.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Aleitamento Materno MdO. 2006. Available at: https://www.febrasgo.org.br/images/arquivos/manuais/Manuais_Novos/aleitamento_.pdf.

  14. Cancer CGoHFiB. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet. 2002;360(9328):187–95.

    Article  Google Scholar 

  15. Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67(3):253–6.

    Article  PubMed  Google Scholar 

  16. Marchbanks PA, Curtis KM, Mandel MG, Wilson HG, Jeng G, Folger SG, et al. Oral contraceptive formulation and risk of breast cancer. Contraception. 2012;85(4):342–50.

    Article  CAS  PubMed  Google Scholar 

  17. Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø. Contemporary hormonal contraception and the risk of breast cancer. N Engl J Med. 2017;377(23):2228–39.

    Article  PubMed  Google Scholar 

  18. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.

    Article  CAS  PubMed  Google Scholar 

  19. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291(14):1701–12.

    Article  CAS  PubMed  Google Scholar 

  20. Manson JE, Chlebowski RT, Stefanick ML, Aragaki AK, Rossouw JE, Prentice RL, et al. Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials. JAMA. 2013;310(13):1353–68.

    Article  CAS  PubMed  Google Scholar 

  21. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet. 1997;350(9084):1047–59.

    Google Scholar 

  22. Kabat GC, Kim MY, Lee JS, Ho GY, Going SB, Beebe-Dimmer J, et al. Metabolic obesity phenotypes and risk of breast cancer in postmenopausal women. Cancer Epidemiol Biomark Prev. 2017;26(12):1730–5.

    Article  Google Scholar 

  23. Park SY, Kolonel LN, Lim U, White KK, Henderson BE, Wilkens LR. Alcohol consumption and breast cancer risk among women from five ethnic groups with light to moderate intakes: the Multiethnic Cohort Study. Int J Cancer. 2014;134(6):1504–10.

    Article  CAS  PubMed  Google Scholar 

  24. Bjerkaas E, Parajuli R, Weiderpass E, Engeland A, Maskarinec G, Selmer R, et al. Smoking duration before first childbirth: an emerging risk factor for breast cancer? Results from 302,865 Norwegian women. Cancer Causes Control. 2013;24(7):1347–56.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Bloom JR, Stewart SL, Hancock SL. Breast cancer screening in women surviving Hodgkin disease. Am J Clin Oncol. 2006;29(3):258–66.

    Article  PubMed  Google Scholar 

  26. Wolden SL, Hancock SL, Carlson RW, Goffinet DR, Jeffrey SS, Hoppe RT. Management of breast cancer after Hodgkin's disease. J Clin Oncol. 2000;18(4):765–72.

    Article  CAS  PubMed  Google Scholar 

  27. Cutuli B, Borel C, Dhermain F, Magrini SM, Wasserman TH, Bogart JA, et al. Breast cancer occurred after treatment for Hodgkin's disease: analysis of 133 cases. Radiother Oncol. 2001;59(3):247–55.

    Article  CAS  PubMed  Google Scholar 

  28. Board WCoTE. Breast Tumours. Lyon: International Agency for Research on Cancer; 2019.

    Google Scholar 

  29. Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K. Atypical hyperplasia of the breast--risk assessment and management options. N Engl J Med. 2015;372(1):78–89.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Said SM, Visscher DW, Nassar A, Frank RD, Vierkant RA, Frost MH, et al. Flat epithelial atypia and risk of breast cancer: a Mayo cohort study. Cancer. 2015;121(10):1548–55.

    Article  PubMed  Google Scholar 

  31. To T, Wall C, Baines CJ, Miller AB. Is carcinoma in situ a precursor lesion of invasive breast cancer? Int J Cancer. 2014;135(7):1646–52.

    Article  PubMed  Google Scholar 

  32. Ford D, Easton DF, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet. 1998;62:676–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Female breast cancer — cancer stat facts. Available at: https://seer.cancer.gov/statfacts/html/breast.html. Accessed on 30/09/2020.

  34. Genetics of Breast and Gynecologic Cancers (PDQ®)–Health professional version https://www.cancer.gov/types/breast/hp/breast-ovarian-genetics-pdq.

  35. Lynch HT, Watson P, Lynch JF. Epidemiology and risk factors. Clin Obstet Gynecol. 1989;32(4):750–60.

    Article  CAS  PubMed  Google Scholar 

  36. Giardiello FM, Brensinger JD, Tersmette AC, Goodman SN, et al. Very high risk of cancer in familial Peutz–Jeghers syndrome. Gastroenterology. 2000;119(6):1447–53.

    Article  CAS  PubMed  Google Scholar 

  37. Tan MH, Mester JL, Ngeow J, Rybicki LA, et al. Lifetime cancer risks in individuals with Germline PTEN mutations. Clin Cancer Res. 2012;18(2):400–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. De GrèveJ, Sermijn E, Brakeleer SD, et al. Hereditary breast cancer from bench to bedside. Curr Opin Oncol. 2008;20:605–13.

    Article  Google Scholar 

  39. Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers. JAMA. 2017;317(23):2402–16.

    Article  CAS  PubMed  Google Scholar 

  40. BRCA mutations: cancer risk and genetic testing fact sheet. Available at: https://www.cancer.gov/about-cancer/causesprevention/genetics/brca-fact-sheet. Accessed on 30/09/2020.

  41. Scalia-Wilbur J, Colins BL, Penson RT, Dizon DS. Breast cancer risk assessment: moving beyond BRCA 1 and 2. Semin Radiat Oncol. 2016;26(1):3–8.

    Article  PubMed  Google Scholar 

  42. NCCN Guidelines. Available at: https://www.nccn.org/professionals/physician_gls/pdf/genetics_bop.pdf. Accessed on 30/09/2020.

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Authors and Affiliations

  1. Departamento de Mastologia, Instituto do Cancer do Estado de Sao Paulo ICESP, São Paulo, SP, Brazil

    Sergio Masili-Oku, Angela Trinconi, Gabriela Boufelli & Jose Roberto Filassi

Authors
  1. Sergio Masili-Oku
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  2. Angela Trinconi
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  3. Gabriela Boufelli
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  4. Jose Roberto Filassi
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Corresponding author

Correspondence to Sergio Masili-Oku .

Editor information

Editors and Affiliations

  1. Breast Imaging Department, Hospital Sírio-Libanês and Instituto de Radiologia (INRAD), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, São Paulo, Brazil

    Su Jin Kim Hsieh

  2. Department of Radiology, University of California Davis, Sacramento, CA, USA

    Elizabeth Anne Morris

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Masili-Oku, S., Trinconi, A., Boufelli, G., Filassi, J.R. (2022). Risk Factors for Breast Cancer. In: Kim Hsieh, S.J., Morris, E.A. (eds) Modern Breast Cancer Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-84546-9_2

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  • DOI: https://doi.org/10.1007/978-3-030-84546-9_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-84545-2

  • Online ISBN: 978-3-030-84546-9

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