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Chronic Kidney Disease in Non-renal Solid Organ Transplantation

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Approaches to Chronic Kidney Disease

Abstract

Acute and chronic kidney diseases (AKI and CKD) are frequently seen in non-renal solid organ transplant (NR-SOT) recipients. Assessing kidney function in this population remains a challenge as estimates of GFR are based on serum creatinine, which can be falsely low in these patients due to sarcopenia. Using CKD-EPI cystatin-C based equation to assess eGFR can mitigate this problem, but it is not always used due to lack of availability and costs. In addition to calcineurin inhibitor use, numerous peri-transplant factors also contribute to the development of AKI and CKD among NR-SOT recipients. Renoprotective strategies and management of CKD and its complications among NR-SOT recipients should follow general expert guidelines. Among liver transplant candidates, guidelines exist for simultaneaous liver-kidney transplant and rescue kidney transplant for those who undergo liver transplant alone. At the time of writing, no guidelines exist for combined heart-kidney transplant. A multidisciplinary approach with open communication between transplant teams and a nephrologist is imperative to the care of NR-SOT recipients with kidney dysfunction.

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Authors and Affiliations

  1. Medicine-Nephrology, Johns Hopkins University, Baltimore, MD, USA

    Christina Mejia

  2. Division of Nephrology, Hypertension and Transplantation, Thomas Jefferson University Hospital, Philadelphia, PA, USA

    Anju Yadav

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  1. Christina Mejia
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Correspondence to Anju Yadav .

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Editors and Affiliations

  1. Thomas Jefferson University, Philadelphia, PA, USA

    Jerry McCauley

  2. Department of Medicine, Division of Nephrology, Sidney Kimmel School of Medicine, Thomas Jefferson University, Philadelphia, PA, USA

    Seyed Mehrdad Hamrahian

  3. Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA

    Omar H. Maarouf

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Mejia, C., Yadav, A. (2022). Chronic Kidney Disease in Non-renal Solid Organ Transplantation. In: McCauley, J., Hamrahian, S.M., Maarouf, O.H. (eds) Approaches to Chronic Kidney Disease . Springer, Cham. https://doi.org/10.1007/978-3-030-83082-3_17

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  • DOI: https://doi.org/10.1007/978-3-030-83082-3_17

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-83082-3

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