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Cell Therapy and Transplantation

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Textbook of Liver Transplantation

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Abstract

Cell therapy is the most effective therapeutic alternative to liver transplantation for advanced liver diseases. Primary hepatocyte transplantation was the first procedure of cell therapy investigated. Although promising preclinical and clinical results have been achieved with this technique, it shown some of the limitations described for liver transplantation such as the shortage of liver tissues for hepatocytes isolation, and the risk of rejection against allogeneic cell.

Consequently, other cell types have been considered, mainly focusing on the promising therapeutic potential of stem cells, including embryonic stem cells, bone marrow-derived hematopoietic stem cells, mesenchymal stem cells and, most recently, induced pluripotent stem cells. Here we summarize the state of the art of cell therapy strategies for the treatment of liver disease, highlighting their advantages and disadvantages.

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Authors and Affiliations

  1. Department of Surgery, Oncology and Gastroenterology, Gastroenterology/Multivisceral Transplant Section, University/Hospital Padua, Padua, Italy

    Francesco Paolo Russo & Debora Bizzaro

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  1. Francesco Paolo Russo
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Correspondence to Francesco Paolo Russo .

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  1. Department of Surgery, Oncology, and Gastroenterology Mutltivisceral Transplant Unit, University of Padua, Padua, Italy

    Patrizia Burra

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Russo, F.P., Bizzaro, D. (2022). Cell Therapy and Transplantation. In: Burra, P. (eds) Textbook of Liver Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-82930-8_43

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