Abstract
The nervous system is an ensemble of organs that transmit and process external information and are responsible for the adaption to the external environment and homeostasis control of the internal environment. The nervous system of vertebrates is divided into the central nervous system (CNS) and peripheral nervous system (PNS) due to its structural features. The CNS, which includes the brain and the spinal cord, processes information from external stimuli and assembles orders suitable for these stimuli. The CNS then sends signals to control other organs/tissues. On the other hand, the PNS connects the CNS to other organs/tissues and functions as a signal pathway. Therefore, the decline and loss of various functions due to injuries of the nervous system cause an impaired quality of life (QOL) and eventually the termination of life activities. Here, we report mainly on decellularized neural tissue and its application as a substrate for the regeneration of the nervous system.
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References
Archibald SJ, Krarup C, Shefner J, Li ST, Madison RD (1991) A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. J Comp Neurol 306(4):685–696
Berry M, Hall S, Follows R, Rees L, Gregson N, Sievers J (1988) Response of axons and glia at the site of anastomosis between the optic nerve and cellular or acellular sciatic nerve grafts. J Neurocytol 17(6):727–744
Berry M, Rees L, Hall S, Yiu P, Sievers J (1988) Optic axons regenerate into sciatic nerve isografts only in the presence of Schwann cells. Brain Res Bull 20(2):223–231
Cai M, Huang T, Hou B, Guo Y (2017) Role of demyelination efficiency within acellular nerve scaffolds during nerve regeneration across peripheral defects. Biomed Res Int 2017:1–10
Chen CJ, Ou YC, Liao SL, Chen WY, Chen SY, Wu CW, Wang CC, Wang WY, Huang YS, Hsu SH (2007) Transplantation of bone marrow stromal cells for peripheral nerve repair. Exp Neurol 204(1):443–453
Crapo PM, Gilbert TW, Badylak SF (2011) An overview of tissue and whole organ decellularization processes. Biomaterials 32(12):3233–3243
Crapo PM, Tottey S, Slivka PF, Badylak SF (2014) Effects of biologic scaffolds on human stem cells and implications for CNS tissue engineering. Tissue Eng Part A 20(1–2):313–323
David S, Aguayo AJ (1981) Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats. Science 214(4523):931–933
De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH (2003) Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 174(3):101–109
De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK (2003) Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett 89(2–3):267–270
DeQuach JA, Yuan SH, Goldstein LS, Christman KL (2011) Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds. Tissue Eng Part A 17(21–22):2583–2592
Gulati AK (1988) Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve. J Neurosurg 68(1):117–123
Guo SZ, Ren XJ, Wu B, Jiang T (2010) Preparation of the acellular scaffold of the spinal cord and the study of biocompatibility. Spinal Cord 48(7):576–581
Hadlock T, Elisseeff J, Langer R, Vacanti J, Cheney M (1998) A tissue-engineered conduit for peripheral nerve repair. Arch Otolaryngol Head Neck Surg 124(10):1081–1086
Hoben G, Yan Y, Iyer N, Newton P, Hunter DA, Moore AM, Sakiyama-Elbert SE, Wood MD, Mackinnon SE (2015) Comparison of acellular nerve allograft modification with Schwann cells or VEGF. Hand (n y) 10(3):396–402
Huang H, Xiao H, Liu H, Niu Y, Yan R, Hu M (2015) A comparative study of acellular nerve xenografts and allografts in repairing rat facial nerve defects. Mol Med Rep 12(4):6330–6336
Hudson TW, Zawko S, Deister C, Lundy S, Hu CY, Lee K, Schmidt CE (2004) Optimized acellular nerve graft is immunologically tolerated and supports regeneration. Tissue Eng 10(11–12):1641–1651
Hudson TW, Liu SY, Schmidt CE (2004) Engineering an improved acellular nerve graft via optimized chemical processing. Tissue Eng 10(10–12):1346–1358
Kingham PJ, Kalbermatten DF, Mahay D, Armstrong SJ, Wiberg M, Terenghi G (2007) Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro. Exp Neurol 207(2):267–274
Li C, Zhang X, Cao R, Yu B, Liang H, Zhou M, Li D, Wang Y, Liu E (2012) Allografts of the acellular sciatic nerve and brain-derived neurotrophic factor repair spinal cord injury in adult rats. PLoS One 7(8):e42813
Liu G, Cheng Y, Guo S, Feng Y, Li Q, Jia H, Wang Y, Tong L, Tong X (2011) Transplantation of adipose-derived stem cells for peripheral nerve repair. Int J Mol Med 28(4):565–572
Liu J, Chen J, Liu B, Yang C, Xie D, Zheng X, Xu S, Chen T, Wang L, Zhang Z, Bai X, Jin D (2013) Acellular spinal cord scaffold seeded with mesenchymal stem cells promotes long-distance axon regeneration and functional recovery in spinal cord injured rats. J Neurol Sci 325(1–2):127–136
Marquardt LM, Ee X, Iyer N, Hunter D, Mackinnon SE, Wood MD, Sakiyama-Elbert SE (2015) Finely tuned temporal and spatial delivery of GDNF promotes enhanced nerve regeneration in a long nerve defect model. Tissue Eng Part A 21(23–24):2852–2864
Matsumoto K, Ohnishi K, Kiyotani T, Sekine T, Ueda H, Nakamura T, Endo K, Shimizu Y (2000) Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res 868(2):315–328
McDonald JW, Sadowsky C (2002) Spinal-cord injury. Lancet 359(9304):417–425
Medberry CJ, Crapo PM, Siu BF, Carruthers CA, Wolf MT, Nagarkar SP, Agrawal V, Jones KE, Kelly J, Johnson SA, Velankar SS, Watkins SC, Modo M, Badylak SF (2013) Hydrogels derived from central nervous system extracellular matrix. Biomaterials 34(4):1033–1040
Nagao RJ, Lundy S, Khaing ZZ, Schmidt CE (2011) Functional characterization of optimized acellular peripheral nerve graft in a rat sciatic nerve injury model. Neurol Res 33(6):600–608
Nakamura T, Inada Y, Fukuda S, Yoshitani M, Nakada A, Itoi S, Kanemaru S, Endo K, Shimizu Y (2004) Experimental study on the regeneration of peripheral nerve gaps through a polyglycolic acid-collagen (PGA-collagen) tube. Brain Res 1027(1–2):18–29
Neubauer D, Graham JB, Muir D (2007) Chondroitinase treatment increases the effective length of acellular nerve grafts. Exp Neurol 207(1):163–170
Nicoli Aldini N, Perego G, Cella GD, Maltarello MC, Fini M, Rocca M, Giardino R (1996) Effectiveness of a bioabsorbable conduit in the repair of peripheral nerves. Biomaterials 17(10):959–962
Philips C, Campos F, Roosens A, Sánchez-Quevedo MDC, Declercq H, Carriel V (2018) Qualitative and quantitative evaluation of a novel detergent-based method for decellularization of peripheral nerves. Ann Biomed Eng 46(11):1921–1937
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143–147
Saheb-Al-Zamani M, Yan Y, Farber SJ, Hunter DA, Newton P, Wood MD, Stewart SA, Johnson PJ, Mackinnon SE (2013) Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence. Exp Neurol 247:165–177
Sondell M, Lundborg G, Kanje M (1998) Regeneration of the rat sciatic nerve into allografts made acellular through chemical extraction. Brain Res 795(1–2):44–54
Szynkaruk M, Kemp SW, Wood MD, Gordon T, Borschel GH (2013) Experimental and clinical evidence for use of decellularized nerve allografts in peripheral nerve gap reconstruction. Tissue Eng Part B Rev 19(1):83–96
Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JE (1999) Traumatic brain injury in the United States: a public health perspective. J Head Trauma Rehabil 14(6):602–615
Volpato FZ, Führmann T, Migliaresi C, Hutmacher DW, Dalton PD (2013) Using extracellular matrix for regenerative medicine in the spinal cord. Biomaterials 34(21):4945–4955
Wang JY, Liou A, Ren ZH, Zhang L, Brown BN, Cui XT, Badylak SF, Cai YN, Guan YQ, Leak RK, Chen J, Ji X, Chen L (2013) Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats. CNS Neurol Disord Drug Targets 12(3):413–425
Whitlock EL, Tuffaha SH, Luciano JP, Yan Y, Hunter DA, Magill CK, Moore AM, Tong AY, Mackinnon SE, Borschel GH (2009) Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve 39(6):787–799
Whitworth IH, Brown RA, Doré C, Green CJ, Terenghi G (1995) Orientated mats of fibronectin as a conduit material for use in peripheral nerve repair. J Hand Surg Br 20(4):429–436
Wood MD, Kemp SW, Liu EH, Szynkaruk M, Gordon T, Borschel GH (2014) Rat-derived processed nerve allografts support more axon regeneration in rat than human-derived processed nerve xenografts. J Biomed Mater Res A 102(4):1085–1091
Wu Y, Wang J, Shi Y, Pu H, Leak RK, Liou AKF, Badylak SF, Liu Z, Zhang J, Chen J, Chen L (2017) Implantation of brain-derived extracellular matrix enhances neurological recovery after traumatic brain injury. Cell TransplAnt 26(7):1224–1234
Xue H, Zhang XY, Liu JM, Song Y, Li YF, Chen D (2013) Development of a chemically extracted acellular muscle scaffold seeded with amniotic epithelial cells to promote spinal cord repair. J Biomed Mater Res A 101(1):145–156
Yamaguchi Y (2000) Lecticans: organizers of the brain extracellular matrix. Cell Mol Life Sci 57(2):276–289
Yan Y, Wood MD, Hunter DA, Ee X, Mackinnon SE, Moore AM (2016) The effect of short nerve grafts in series on axonal regeneration across isografts or acellular nerve allografts. J Hand Surg Am 41(6):e113–e121
Yin H, Jiang T, Deng X, Yu M, Xing H, Ren X (2018) A cellular spinal cord scaffold seeded with rat adipose-derived stem cells facilitates functional recovery via enhancing axon regeneration in spinal cord injured rats. Mol Med Rep 17(2):2998–3004
Zhang XY, Xue H, Liu JM, Chen D (2012) Chemically extracted acellular muscle: a new potential scaffold for spinal cord injury repair. J Biomed Mater Res A 100(3):578–587
Zhang L, Zhang F, Weng Z, Brown BN, Yan H, Ma XM, Vosler PS, Badylak SF, Dixon CE, Cui XT, Chen J (2013) Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury. Tissue Eng Part A 19(17–18):1909–1918
Zhang Y, Zhang H, Katiella K, Huang W (2014) Chemically extracted acellular allogeneic nerve graft combined with ciliary neurotrophic factor promotes sciatic nerve repair. Neural Regen Res 9(14):1358–1364
Zheng C, Zhu Q, Liu X, Huang X, He C, Jiang L, Quan D (2014) Improved peripheral nerve regeneration using acellular nerve allografts loaded with platelet-rich plasma. Tissue Eng Part A 20(23–24):3228–3240
Zhou X, He B, Zhu Z, He X, Zheng C, Xu J, Jiang L, Gu L, Zhu J, Zhu Q, Liu X (2014) Etifoxine provides benefits in nerve repair with acellular nerve grafts. Muscle Nerve 50(2):235–243
Zhu G, Lou W (2014) Regeneration of facial nerve defects with xenogeneic acellular nerve grafts in a rat model. Head Neck 36(4):481–486
Zhu J, Lu Y, Yu F, Zhou L, Shi J, Chen Q, Ding W, Wen X, Ding YQ, Mei J, Wang J (2018) Effect of decellularized spinal scaffolds on spinal axon regeneration in rats. J Biomed Mater Res A 106(3):698–705
Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7(2):211–228
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Ikegami, Y., Ijima, H. (2021). Decellularization of Nervous Tissues and Clinical Application. In: Kajbafzadeh, AM. (eds) Decellularization Methods of Tissue and Whole Organ in Tissue Engineering. Advances in Experimental Medicine and Biology, vol 1345. Springer, Cham. https://doi.org/10.1007/978-3-030-82735-9_19
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DOI: https://doi.org/10.1007/978-3-030-82735-9_19
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