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Normal Pressure Hydrocephalus

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Hybrid PET/MR Neuroimaging

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Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is one of the few reversible causes of cognitive impairment, and many patients can be effectively treated with surgical placement of a ventricular shunt. The clinical diagnosis is based on the classic triad of cognitive decline, gait impairment, and urinary incontinence, combined with MRI evidence of ventricular enlargement. However, the underlying pathophysiological processes that lead to the development of iNPH remain unknown. In addition to MRI, 18F-FDG PET can be used to exclude neurodegenerative diseases that mimic iNPH, including Alzheimer’s disease (AD). Improving outcomes will rest upon developing more specific methods of differentiating iNPH from disease mimics and identifying patients that will best respond to shunt surgery.

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Authors and Affiliations

  1. NewYork Presbyterian-Weill Cornell, Department of Radiology, New York, NY, USA

    Ilhami Kovanlikaya & Gloria C. Chiang

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  1. Ilhami Kovanlikaya
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  2. Gloria C. Chiang
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Correspondence to Gloria C. Chiang .

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Editors and Affiliations

  1. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, The Feinstein Institutes for Medical Research, Manhasset, NY, USA

    Ana M. Franceschi

  2. Stony Brook University Hospital, Stony Brook, NY, USA

    Dinko Franceschi

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Kovanlikaya, I., Chiang, G.C. (2022). Normal Pressure Hydrocephalus. In: Franceschi, A.M., Franceschi, D. (eds) Hybrid PET/MR Neuroimaging. Springer, Cham. https://doi.org/10.1007/978-3-030-82367-2_38

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  • DOI: https://doi.org/10.1007/978-3-030-82367-2_38

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