Skip to main content

In Patients with Traumatic Extremity Wounds Is Negative Pressure Wound Therapy Superior as Compared to Standard Dressing Changes?

  • Chapter
  • First Online:
Difficult Decisions in Trauma Surgery

Abstract

Over the past 25 years, negative pressure wound therapy (NPWT) has gained acceptance as an effective treatment modality for traumatic extremity soft tissue defects and wounds. Its rapid adoption into the armamentarium of a majority of trauma surgeons and wound care specialists could imply that it is superior to more traditional methods of wound care. Specifically, NPWT is alleged to accelerate healing at the cellular level through a variety of physiologic mechanisms, which should translate into significant improvements in patient outcomes. While proponents claim that NPWT is associated with enhanced wound healing, shorter hospital length of stays, lower rates of infection, and a better quality of life, an in-depth review of the literature may suggest otherwise. Therefore, the aim of this chapter is to determine if patients with traumatic extremity wounds benefit from NPWT when compared to standard dressings (wet-to-moist gauze) regarding healing, timing, infections, and life quality.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Negative pressure wound therapy market to reach USD 2.74 billion by 2026; Rising prevalence of surgical site infections to boost growth: fortune business insights [Internet]. Globe Newswire. New York, NY; 2020 [cited 2020 Apr 13]. Available from https://www.globenewswire.com/news-release/2020/01/21/1972728/0/en/Negative-Pressure-Wound-Therapy-Market-to-Reach-USD-2-74-Billion-by-2026-Rising-Prevalence-of-Surgical-Site-Infections-to-Boost-Growth-Fortune-Business-Insights.html

  2. Kanakaris NK, Thanasas C, Keramaris N, Kontakis G, Granick MS, Giannoudis PV. The efficacy of negative pressure wound therapy in the management of lower extremity trauma: review of clinical evidence. Injury. 2007;38:S8–17.

    Article  Google Scholar 

  3. Kim J-H, Lee D-H. Negative pressure wound therapy vs. conventional management in open tibia fractures: systematic review and meta-analysis. Injury. 2019;50:1764–72.

    Article  Google Scholar 

  4. Mouës CM, Heule F, Hovius SER. A review of topical negative pressure therapy in wound healing: sufficient evidence? Am J Surg. 2011;201:544–56.

    Article  Google Scholar 

  5. Huang C, Leavitt T, Bayer LR, Orgill DP. Effect of negative pressure wound therapy on wound healing. Curr Probl Surg. 2014;51:301–31.

    Article  Google Scholar 

  6. Gregor S. Negative pressure wound therapy. Arch Surg. 2008;143:189.

    Article  Google Scholar 

  7. Müllner T, Mrkonjic L, Kwasny O, Vecsei V. The use of negative pressure to promote the healing of tissue defects: a clinical trial using the vacuum sealing technique. Br J Plast Surg. 1997;50:194–9.

    Article  Google Scholar 

  8. Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment. Ann Plast Surg. 1997;38:563–77.

    Article  CAS  Google Scholar 

  9. DeFranzo AJ, Argenta LC, Marks MW, Molnar JA, David LR, Webb LX, et al. The use of vacuum-assisted closure therapy for the treatment of lower-extremity wounds with exposed bone. Plast Reconstr Surg. 2001;108:1184–91.

    Article  CAS  Google Scholar 

  10. Herscovici D, Sanders RW, Scaduto JM, Infante A, DiPasquale T. Vacuum-assisted wound closure (VAC therapy) for the management of patients with high-energy soft tissue injuries. J Orthop Trauma. 2003;17:683–8.

    Article  Google Scholar 

  11. Hinck D, Franke A, Gatzka F. Use of vacuum-assisted closure negative pressure wound therapy in combat-related injuries—literature review. Mil Med. 2010;175:173–81.

    Article  Google Scholar 

  12. Burris DG, Dougherty PJ, Elliot DC, Fitz Harris JB, Holcomb JB, Hetz SP, et al. Soft tissue injuries. In: Cubano MA, Butler FK, editors. Emergency war surgery. 3rd ed. Washington, DC: Borden Institute; Water Reed Army Medical Center; 2004. p. 478.

    Google Scholar 

  13. Fang R, Dorlac WC, Flaherty SF, Tuman C, Cain SM, Popey TLC, et al. Feasibility of negative pressure wound therapy during intercontinental aeromedical evacuation of combat casualties. J Trauma Inj Infect Crit Care. 2010;69:S140–5.

    Article  Google Scholar 

  14. Parrett BM, Matros E, Pribaz JJ, Orgill DP. Lower extremity trauma: trends in the management of soft-tissue reconstruction of open tibia-fibula fractures. Plast Reconstr Surg. 2006;117:1315–22.

    Article  CAS  Google Scholar 

  15. Liu X, Zhang H, Cen S, Huang F. Negative pressure wound therapy versus conventional wound dressings in treatment of open fractures: a systematic review and meta-analysis. Int J Surg. 2018;53:72–9.

    Article  Google Scholar 

  16. Wilson CB. Adoption of new surgical technology. BMJ. 2006;332:112–4.

    Article  Google Scholar 

  17. Levinson DR. Comparison of prices for negative pressure wound therapy pumps [Internet]. New York. 2009. Available from https://oig.hhs.gov/oei/reports/oei-02-07-00660.pdf

  18. Schlatterer DR, Hirschfeld AG, Webb LX. Negative pressure wound therapy in grade IIIB tibial fractures: fewer infections and fewer flap procedures? Clin Orthop Relat Res. 2015;473:1802–11.

    Article  Google Scholar 

  19. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, et al. The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures. J Orthop Trauma. 2007;21:11–7.

    Article  Google Scholar 

  20. Dedmond BT, Kortesis B, Punger K, Simpson J, Argenta J, Kulp B, et al. Subatmospheric pressure dressings in the temporary treatment of soft tissue injuries associated with type III open tibial shaft fractures in children. J Pediatr Orthop. 2006;26:728–32.

    Article  Google Scholar 

  21. Liu DSH, Sofiadellis F, Ashton M, Mac Gill K, Webb A. Early soft tissue coverage and negative pressure wound therapy optimises patient outcomes in lower limb trauma. Injury. 2012;43:772–8.

    Article  Google Scholar 

  22. Stannard JP, Robinson JT, Anderson ER, McGwin G, Volgas DA, Alonso JE. Negative pressure wound therapy to treat hematomas and surgical incisions following high-energy trauma. J Trauma Inj Infect Crit Care. 2006;60:1301–6.

    Article  Google Scholar 

  23. Pollak AN. Use of negative pressure wound therapy with reticulated open cell foam for lower extremity trauma. J Orthop Trauma. 2008;22:S142–5.

    Article  Google Scholar 

  24. Älgå A, Wong S, Haweizy R, Conneryd Lundgren K, von Schreeb J, Malmstedt J. Negative-pressure wound therapy versus standard treatment of adult patients with conflict-related extremity wounds: protocol for a randomized controlled trial. JMIR Res Protoc. 2018;7:e12334.

    Article  Google Scholar 

  25. Costa ML, Achten J, Bruce J, Tutton E, Petrou S, Lamb SE, et al. Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb. JAMA. 2018;319:2280.

    Article  Google Scholar 

  26. Costa ML, Achten J, Knight R, Bruce J, Dutton SJ, Madan J, et al. Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma. JAMA. 2020;323:519.

    Article  Google Scholar 

  27. Shilt JS, Yoder JS, Manuck TA, Jacks L, Rushing J, Smith BP. Role of vacuum-assisted closure in the treatment of pediatric lawnmower injuries. J Pediatr Orthop. 2004;24:482–7.

    Article  Google Scholar 

  28. Arti H, Khorami M, Ebrahimi-Nejad VE-N. Comparison of negative pressure wound therapy (NPWT) and conventional wound dressings in the open fracture wounds. Pakistan J Med Sci. 1969;32(1):65–9.

    Google Scholar 

  29. Kaplan M, Daly D, Stemkowski S. Early intervention of negative pressure wound therapy using vacuum-assisted closure in trauma patients. Adv Skin Wound Care. 2009;22:128–32.

    Article  Google Scholar 

  30. Rezzadeh KS, Nojan M, Buck A, Li A, Vardanian A, Crisera C, et al. The use of negative pressure wound therapy in severe open lower extremity fractures: identifying the association between length of therapy and surgical outcomes. J Surg Res. 2015;199:726–31.

    Article  Google Scholar 

  31. Stannard JP, Volgas DA, Stewart R, McGwin G, Alonso JE. Negative pressure wound therapy after severe open fractures: a prospective randomized study. J Orthop Trauma. 2009;23:552–7.

    Article  Google Scholar 

  32. Virani SR, Dahapute AA, Bava SS, Muni SR. Impact of negative pressure wound therapy on open diaphyseal tibial fractures: a prospective randomized trial. J Clin Orthop Trauma. 2016;7:256–9.

    Article  Google Scholar 

  33. Hahn HM, Lee IJ, Woo K, Park BY. Silver-impregnated negative-pressure wound therapy for the treatment of lower-extremity open wounds. Adv Skin Wound Care. 2019;32:370–7.

    Article  Google Scholar 

  34. Stinner DJ, Waterman SM, Masini BD, Wenke JC. Silver dressings augment the ability of negative pressure wound therapy to reduce bacteria in a contaminated open fracture model. J Trauma Inj Infect Crit Care. 2011;71:S147–50.

    Article  Google Scholar 

  35. Ondieki JG, Khainga SO, Owilla F, Nangole FW. Outcome of foam versus gauze dressings in negative pressure wound therapy for the management of acute traumatic wounds with soft tissue loss at Kenyatta National Hospital. East Afr Med J. 2012;89:230–40.

    CAS  PubMed  Google Scholar 

  36. Iheozor-Ejiofor Z, Newton K, Dumville JC, Costa ML, Norman G, Bruce J. Negative pressure wound therapy for open traumatic wounds. Cochrane Database Syst Rev. 2018;7(7):CD012522.

    PubMed  Google Scholar 

  37. Fries CA, Jeffery SLA, Kay AR. Topical negative pressure and military wounds—a review of the evidence. Injury. 2011;42:436–40.

    Article  CAS  Google Scholar 

  38. Leininger BE, Rasmussen TE, Smith DL, Jenkins DH, Coppola C. Experience with wound VAC and delayed primary closure of contaminated soft tissue injuries in Iraq. J Trauma Inj Infect Crit Care. 2006;61:1207–11.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher J. Dente .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tracy, B.M., Koganti, D., Dente, C.J. (2022). In Patients with Traumatic Extremity Wounds Is Negative Pressure Wound Therapy Superior as Compared to Standard Dressing Changes?. In: Wilson, K., Rogers, S.O. (eds) Difficult Decisions in Trauma Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-81667-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-81667-4_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81666-7

  • Online ISBN: 978-3-030-81667-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics