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Systemic Antibiotic Therapy

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Infection in Knee Replacement

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Abstract

Application of systemic antibiotics plays an important role in the perioperative management of knee revision arthroplasty. Concepts may vary, depending on the corresponding surgical approach and the underlying pathogen. Biofilm prevention or disruption for example requires an appropriate and well-timed application of antibiotics. The management of PJI is an interdisciplinary approach including orthopedic surgeons, microbiologists, and infection specialists. Sometimes plastic surgeons or wound specialist need to be consulted as well.

The present chapter provides an overview of systemic antibiotic treatment in context of surgical management, concepts for empirical and focused therapy, as well as pathogen-specific considerations. The summary of the recommended management is given in the table to help clinicians to choose the right treatment regimen depending on the individual requirements in their particular cases.

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Author information

Authors and Affiliations

  1. Gelenkzentrum Mittelrhein, Koblenz, Germany

    Philip P. Roessler

  2. Medical Faculty, University of Bonn, Bonn, Germany

    Philip P. Roessler

  3. Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany

    Gunnar T. R. Hischebeth

  4. Center for Orthopaedics and Trauma Surgery, University Hospital Mannheim, Mannheim, Germany

    Sascha Gravius

Authors
  1. Philip P. Roessler
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  2. Gunnar T. R. Hischebeth
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  3. Sascha Gravius
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Corresponding author

Correspondence to Philip P. Roessler .

Editor information

Editors and Affiliations

  1. Università Campus Bio-Medico di Roma, Rome, Italy

    Umile Giuseppe Longo

  2. Arthroplasty & Sports Medicine, Nicolaas Institute of Constructive Orthopedic Research, Jakarta, Indonesia

    Nicolaas C. Budhiparama

  3. Département de Chirurgie Orthopédiq, Hôpital de la Croix-Rousse, Lyon Cedex 04, France

    Sébastien Lustig

  4. Department of Orthopaedics and Traumatology, Center of Joint Replacement, Medical Director of the University Hospital, University of Brandenburg an der Havel, Brandenburg, Germany

    Roland Becker

  5. Clínica do Dragao - Espregueira-Mendes, Braga, Portugal

    João Espregueira-Mendes

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Roessler, P.P., Hischebeth, G.T.R., Gravius, S. (2022). Systemic Antibiotic Therapy. In: Longo, U.G., Budhiparama, N.C., Lustig, S., Becker, R., Espregueira-Mendes, J. (eds) Infection in Knee Replacement. Springer, Cham. https://doi.org/10.1007/978-3-030-81553-0_12

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  • DOI: https://doi.org/10.1007/978-3-030-81553-0_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-81552-3

  • Online ISBN: 978-3-030-81553-0

  • eBook Packages: MedicineMedicine (R0)

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