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Cancer Antigens: Sources, Generation, and Presentation

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  • First Online:
Handbook of Cancer and Immunology

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Abstract

Immune surveillance by T cells requires antigen presentation by molecules encoded by MHC (major histocompatibility complex) class I and class II genes in a process termed MHC restriction. MHC restriction is defined as a process in which protein antigens are proteolytically processed to short peptides, which are assembled with MHC molecules, and then displayed as peptide-bound MHC molecules at the surface of cells. Therefore, knowledge of peptide antigens presented by MHC molecules can yield information on the sources of tumor antigens, ways to track T cell responses to tumors, and targets for cancer vaccines and cell therapies. This chapter provides an overview of cancer antigens, their sources, and the mechanisms by which cells generate and present such antigens.

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Acknowledgments

Supported by a Research Career Scientist (IK6 BX004595) & Merit (I01 BX001444 & BX001610) Awards from the VA and by NIH grants (R01 AI137082 & DE027749).

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  1. US Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA

    Sebastian Joyce

  2. Division of Molecular Pathogenesis, Department of Pathology, Microbiology, & Immunology; Vanderbilt Center for Immunobiology; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA

    Sebastian Joyce

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  1. Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Sweden

    Nima Rezaei

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Joyce, S. (2023). Cancer Antigens: Sources, Generation, and Presentation. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_38-1

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