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Cancer Rehabilitation or Physical Exercise Effect on Immune Function

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Handbook of Cancer and Immunology

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Abstract

Physical exercise is frequently performed by cancer patients during or after multiple chemotherapy and radiation cycle and has been reported to improve not only physical function, but also health-related quality of life such as fatigue, sleep disturbance, and loss of appetite in such patients. In recent years, there have been increasing reports that regular exercise prolongs overall survival and reduces the risk of recurrence in cancer patients. The biological mechanisms of these improvements are thought to involve immune function to a large extent. In particular, physical exercise activates immune cells such as natural killer cells and suppresses tumor necrosis factor by secreting anti-inflammatory cytokines. Long-term moderate exercise may be most effective in terms of cell activation and suppression of tumor necrosis factor. This chapter explains the effects of physical exercise on immune function in cancer patients using recently published papers and discusses the importance of physical exercise.

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Authors and Affiliations

  1. Department of Physical Therapy, School of Health Sciences, Fukushima Medical University, Fukushima, Japan

    Shinichiro Morishita

  2. Department of Palliative, Rehabilitation & Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jack B. Fu

  3. Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan

    Atsuhiro Tsubaki

Authors
  1. Shinichiro Morishita
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  2. Jack B. Fu
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  3. Atsuhiro Tsubaki
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Correspondence to Shinichiro Morishita .

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Editors and Affiliations

  1. Division of Clinical Immunology, Karolinska University Hospital, Huddinge, Sweden

    Nima Rezaei

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Morishita, S., Fu, J.B., Tsubaki, A. (2023). Cancer Rehabilitation or Physical Exercise Effect on Immune Function. In: Rezaei, N. (eds) Handbook of Cancer and Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-80962-1_354-1

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  • DOI: https://doi.org/10.1007/978-3-030-80962-1_354-1

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