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Cervicofacial Nocardiosis in Children

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Pediatric ENT Infections

Abstract

Nocardiosis is a suppurative and granulomatous infectious disease in animals and humans caused by Nocardia spp. [1, 2]. Nocardia species are found extensively in soil, organic matter, and aquatic habitats throughout the world. Considered an opportunistic infection, Nocardia spp. can cause both local and disseminated disease in children and adults, primarily occurring in immunosuppressed patients or after trauma [1, 3, 4].

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References

  1. Chen SCA, Watts MR, Maddocks S, Sorrell TC. Nocardia species. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. 9th ed. Philadelphia: Elsevier; 2020. p. 3059–70.

    Google Scholar 

  2. Spelman D. Clinical manifestations and diagnosis of nocardiosis. In: Sexton DJ, Mitty J (eds). Uptodate; 2020. https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-nocardiosis. Accessed 15 Dec 2020.

  3. Fisher BT. Nocardia. In: Kliegman RM, St Geme III JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson textbook of pediatrics. 21st ed. Philadelphia: Elsevier; 2020. p. 1467–9.

    Google Scholar 

  4. Bennett NJ. Pediatric nocardiosis. In: Steele RW (ed). Medscape; 2018. https://emedicine.medscape.com/article/966919-overview. Accessed 15 Dec 2020.

  5. Harik N, Jacobs RF. Nocardia. In: Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ, editors. Feigin and Cherry’s textbook of pediatric infectious diseases. 8th ed. Philadelphia: Elsevier; 2019. p. 1013–6.

    Google Scholar 

  6. Hall GS, Woods GL. Medical bacteriology. In: McPherson RA RA, Pincus MR, editors. Henry’s clinical diagnosis and management by laboratory methods. 23rd ed; 2017. p. 1114–52.

    Google Scholar 

  7. Lebeaux D, Bergeron E, Berthet J, et al. Antibiotic susceptibility testing and species identification of Nocardia isolates: a retrospective analysis of data from a French expert laboratory, 2010-2015. Clin Microbiol Infect. 2019;25:489–95.

    Article  CAS  Google Scholar 

  8. Cloud JL, Conville PS, Croft A, Harmsen D, Witebsky FG, Carroll KC. Evaluation of partial 16S ribosomal DNA sequencing for identification of Nocardia species by using the MicroSeq 500 system with an expanded database. J Clin Microbiol. 2004;42:578–84.

    Article  CAS  Google Scholar 

  9. Farfour E, Leto J, Barritault M, et al. Evaluation of the Andromas matrix-assisted laser desorption ionization-time of flight mass spectrometry system for identification of aerobically growing Gram-positive bacilli. J Clin Microbiol. 2012;50:2702–7.

    Article  CAS  Google Scholar 

  10. American Academy of Pediatrics. Nocardiosis. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, editors. Red book: 2018 report of the committee on infectious diseases. 31st ed. Itasca: American Academy of Pediatrics; 2018. p. 575–7.

    Google Scholar 

  11. Outhred AC, Watts MR, Chen SC, Sorrell TC. Nocardia infections of the face and neck. Curr Infect Dis Rep. 2011;13:132–40.

    Article  Google Scholar 

  12. Beaman BL, Beaman L. Nocardia species: host-parasite relationships. Clin Microbiol Rev. 1994;7:213–64.

    Article  CAS  Google Scholar 

  13. Lederman ER, Crum NF. A case series and focused review of nocardiosis: clinical and microbiologic aspects. Medicine (Baltimore). 2004;83:300–13.

    Article  Google Scholar 

  14. Baek JO, Kim JS, Lee SK, Ji H, Jeong JH, Lee MJ, Seo IH. Two cases of primary cutaneous nocardiosis caused by intralesional injection. Dermatol Ther. 2019;32:e12775.

    Article  Google Scholar 

  15. Srour ML, Wong V, Wyllie S. Noma, actinomycosis and nocardia. In: Farrar J, Hotez PJ, Junghanss T, Kang G, Lalloo D, White NJ, editors. Manson’s tropical diseases. 23rd ed; 2014. p. 379–84.

    Chapter  Google Scholar 

  16. Lampe RM, Baker CJ, Septimus EJ, Wallace RJ Jr. Cervicofacial nocardiosis in children. J PediatrJ Pediatr. 1981;99:593–5.

    Article  CAS  Google Scholar 

  17. Fergie JE, Purcell K. Nocardiosis in South Texas children. Pediatr Infect Dis J. 2001;20:711–4.

    Article  CAS  Google Scholar 

  18. Beckmeyer WJ. Nocardiosis; report of a successfully treated case of cutaneous granuloma. Pediatrics. 1959;23(1 Pt 1):33–9.

    CAS  PubMed  Google Scholar 

  19. Law BJ, Marks MI. Pediatric nocardiosis. Pediatrics. 1982;70:560–5.

    CAS  PubMed  Google Scholar 

  20. Kumar TS, Scott JX, Viswanathan S, Agarwal I, Raj PM, Lalitha MK. Cervicofacial nocardiosis in an immunocompetent child. Acta Paediatr. 2005;94:1342–3.

    Article  Google Scholar 

  21. Bates RR, Rifkind D. Nocardia brasiliensis lymphocutaneous syndrome. Am J Dis Child. 1971;121:246–7.

    CAS  PubMed  Google Scholar 

  22. Shanbhag NU, Karandikar S, Deshmukkh PA. Disseminated orbital actinomycetoma: a case report. Indian J Ophthalmol. 2010;58:60–3.

    Article  Google Scholar 

  23. Arenas R, Ameen M. Giant grains of Nocardia actinomycetoma. Lancet Infect Dis. 2010;10(1):66.

    Article  Google Scholar 

  24. Boiron P, Stynen D. Immunodiagnosis of nocardiosis. GeneGene. 1992;115:219–22.

    Article  CAS  Google Scholar 

  25. Clinical and Laboratory Standards Institute. Susceptibility testing of aerobic actinomycetes. In: Woods GL, Brown-Elliott BA, Conville PS, et al., editors. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes. 2nd ed. Wayne: CLSI; 2011. p. 29–33.

    Google Scholar 

  26. American Academy of Pediatrics. Antimicrobial therapy according to clinical syndromes: miscellaneous systemic infections. In: John S, Bradley JS, Nelson JD, Barnett ED, et al., editors. Nelson’s pediatric antimicrobial therapy. 26th ed. Itasca: American Academy of Pediatrics; 2020. p. 123–9.

    Google Scholar 

  27. Ameen M, Arenas R, Vasquez del Mercado E, et al. Eff icacy of imipenem therapy for Nocardia actinomycetomas refractory to sulfonamides. J Am Acad Dermatol. 2010;62:239–46.

    Article  CAS  Google Scholar 

  28. Spelman D. Treatment of nocardiosis. In: Sexton DJ, Mitty J (eds). Uptodate; 2020. https://www.uptodate.com/contents/treatment-of-nocardiosis. Accessed: 15 Dec 2020.

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Büyükçam, A., Arısoy, E.S., Correa, A.G. (2022). Cervicofacial Nocardiosis in Children. In: Cingi, C., Arısoy, E.S., Bayar Muluk, N. (eds) Pediatric ENT Infections. Springer, Cham. https://doi.org/10.1007/978-3-030-80691-0_66

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  • DOI: https://doi.org/10.1007/978-3-030-80691-0_66

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