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The Meanings of Prognosis: When and How to Discuss It?

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Palliative Care in Cardiac Intensive Care Units
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Abstract

Prognosis, together with therapy, is one of the physician’s aims when formulating a diagnosis.

These three medical cornerstones have improved thanks to developments in technology and knowledge, albeit privileging the diagnostic and therapeutic aspects, and the prognosis has become a series of outcomes rather than predicting the clinical course of the individual patient’s disease.

The current care model is prevalently based on diagnosis and includes technological and treatment imperatives. This model gives insufficient consideration to the proportionality of treatment, appropriateness and limits of reasonableness, clinical efficacy, ethics, and potential futility of treatment.

These aspects are particularly significant in cardiac intensive care units (CICUs).

Uncertainty is a conditioning aspect in formulating a prognosis. The level of uncertainty is directly proportional to the level of complexity of the patient’s condition, linked to specific characteristics of the primary disease, number of comorbidities, and interaction with non-biological factors (social and family status, financial and environmental factors, and so on).

Prognosis is a difficult and challenging issue to discuss for the physician, patient, and family members. It is a complex process involving the timing of communication (during the acute or stable stages of the illness), the uncertainty and unpredictability of the disease, the extent to which patient and family members want to know how long the patient has to live, and the quality of that time.

Prognosis communication should clarify what can actually be done by the physician, together with the patient’s expectations, “in a context of uncertainty”, while overcoming the inevitable obstacles, not least the psychological and cultural ones of the clinician.

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References

  1. Kleinman A. Catastrophe and caregiving: the failure of medicine as an art. Lancet. 2008;371:22–3.

    Article  PubMed  Google Scholar 

  2. Thomas JM, Cooney LM Jr, Fried TR. Prognosis reconsidered in light of ancient insights-from Hippocrates to modern medicine. JAMA Intern Med. 2019;179:820–3.

    Article  PubMed  Google Scholar 

  3. Hippocrates. Prognostic. Translated by W. H. S. Jones. Loeb Classical Library 148. Cambridge, MA: Harvard University Press; 1923.

    Google Scholar 

  4. Croft P, Altman DG, Deeks JJ. The science of clinical practice: disease diagnosis or patient prognosis? Evidence about “what is likely to happen” should shape clinical practice. BMC Med. 2015;13:20.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bohula EA, Katz JN, van Diepen S, Alviar CL, Baird-Zars VM, et al. Demographics, care patterns, and outcomes of patients admitted to cardiac intensive care units: the critical care cardiology trials network prospective North American Multicenter Registry of cardiac critical illness. JAMA Cardiol. 2019;4:928–35.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Feldman AM. Precision medicine for heart failure: back to the future. J Am Coll Cardiol. 2019;73:1185–8.

    Article  PubMed  Google Scholar 

  7. Lee D. Are guidelines mantra? Musings about uncertainty in medicine. J Card Fail. 2016;22:483–4.

    Article  PubMed  Google Scholar 

  8. Ahn AC, Tewari M, Poon CS, Phillips RS. The clinical applications of a systems approach. PLoS Med. 2006;3:e209.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Fanaroff AC, Califf RM, Windecker S, Smith SC Jr, Lopes RD. Levels of evidence supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018. JAMA. 2019;321:1069–80.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mueller P, Hook CC. Technological and treatment imperatives, life-sustaining technologies, and associated ethical and social challenges. Mayo Clin Proc. 2013;88:641–4.

    Article  PubMed  Google Scholar 

  11. Romanò M. The role of palliative care in the cardiac intensive care unit. Healthcare (Basel). 2019;7:30. https://doi.org/10.3390/healthcare7010030.

  12. Schneiderman LJ, Jecker NS, Jonsen AR. The abuse of futility. Perspect Biol Med. 2018;60:295–313.

    Article  PubMed  Google Scholar 

  13. Wildes KW. The moral paradox of critical care medicine. In: Wildes KW, editor. Critical choises and critical care. Catholic perspective on allocating resources in intensive care medicine. Dordrecht/Boston/London: Academic Publisher; Kluwer; 1995. p. 1–4.

    Google Scholar 

  14. Ridley S, Fisher M. Uncertainty in the end of life care. Curr Opin Crit Care. 2013;19:642–7.

    Article  PubMed  Google Scholar 

  15. Kimbell B, Murray SA, Macpherson S, Boyd K. Embracing inherent uncertainty in advanced illness. BMJ. 2016;354:i3802. https://doi.org/10.1136/bmj.i3802.

    Article  CAS  PubMed  Google Scholar 

  16. Bean RB, Bean WB. Sir William Osler: aphorisms from his bedside teachings and writings. New York: H. Schuman; 1950.

    Google Scholar 

  17. Kurtz F, Snowden DJ. The new dynamics of strategy: sense-making in a complex and complicated world. IBM Syst J. 2003;3:462–83.

    Article  Google Scholar 

  18. Hilton AK, Jones D, Bellomo R. Clinical review: the role of the intensivist and the rapid response team in nosocomial end-of-life care. Crit Care. 2013;17:224.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Callahan D. Remembering the goals of medicine. J Eval Clin Pract. 1999;5:103–6.

    Article  CAS  PubMed  Google Scholar 

  20. Wilkinson D. The self-fulfilling prophecy in intensive care. Theor Med Bioeth. 2009;30:401–10.

    Article  PubMed  Google Scholar 

  21. Sulmasy DP. Do patients die because they have DNR orders or do they have DNR orders because they are going to die? Med Care. 1999;37:719–21.

    Article  CAS  PubMed  Google Scholar 

  22. Romanò M. Facilitating supportive care in cardiac intensive care units. Curr Opin Support Palliat Care. 2020;14:19–24.

    Article  PubMed  Google Scholar 

  23. Paladino J, Lakin JR, Sanders JJ. Communication strategies for sharing prognostic information with patients: beyond survival statistics. JAMA. 2019;322:1345–6.

    Article  PubMed  Google Scholar 

  24. van Diepen S, Katz JN, Morrow DA. Will cardiac intensive care unit admissions warrant appropriate use criteria in the future? Circulation. 2019;140:267–9.

    Article  PubMed  Google Scholar 

  25. Ricou B, Piers R, Flaatten H. ‘Less is more’ in modern ICU: blessings and traps of treatment limitation. Intensive Care Med. 2020;46:110–2.

    Article  CAS  PubMed  Google Scholar 

  26. Charlson ME, Pompei P, Ales KA, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.

    Article  CAS  PubMed  Google Scholar 

  27. Goldfarb M, van Diepen S, Liszkowski M, Jentzer JC, Pedraza I, Cercek B. Noncardiovascular disease and critical care delivery in a contemporary cardiac and medical intensive care unit. J Intensive Care Med. 2019;34:537–43.

    Article  PubMed  Google Scholar 

  28. Jentzer JC, Bennett C, Wiley BM, Murphree DH, Keegan MT, Gajic O, et al. Predictive value of the sequential organ failure assessment score for mortality in a contemporary cardiac intensive care unit population. J Am Heart Assoc. 2018;7:e008169.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Jentzer JC, Anavekar NS, Bennett C, Murphree DH, Keegan MT, Wiley B, et al. Derivation and validation of a novel cardiac intensive care unit admission risk score for mortality. J Am Heart Assoc. 2019;8:e013675. https://doi.org/10.1161/JAHA.119.013675.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Jentzer JC, Anavekar NS, Brenes-Salazar JA, Wiley B, Murphree DH, Bennett C, et al. Admission Braden skin score independently predicts mortality in cardiac intensive care patients. Mayo Clin Proc. 2019;94:1994–2003.

    Article  PubMed  Google Scholar 

  31. Lyle M, Wan SH, Murphree D, Bennett C, Wiley BM, Barsness G, et al. Predictive value of the get with the guidelines heart failure risk score in unselected cardiac intensive care unit patients. J Am Heart Assoc. 2020;9:e012439. https://doi.org/10.1161/JAHA.119.012439.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Straw S, Byrom R, Gierula J, Paton MF, Koshy A, Cubbon R, et al. Predicting one-year mortality in heart failure using the ‘Surprise Question’: a prospective pilot study. Eur J Heart Fail. 2019;21:227–34.

    Article  PubMed  Google Scholar 

  33. Jentzer JC, van Diepen S, Barsness GW, Katz JN, Wiley BM, Bennett CE, et al. Changes in comorbidities, diagnoses, therapies and outcomes in a contemporary cardiac intensive care unit population. Am Heart J. 2019;215:12–9.

    Article  PubMed  Google Scholar 

  34. Smilowitz NR, Mahajan AM, Roe MT, Hellkamp AS, Chiswell K, Gulati M, et al. Mortality of myocardial infarction by sex, age, and obstructive coronary artery disease status in the ACTION registry-GWTG (acute coronary treatment and intervention outcomes network registry-get with the guidelines). Circ Cardiovasc Qual Outcomes. 2017;10:e003443. https://doi.org/10.1161/CIRCOUTCOMES.116.003443.

    Article  PubMed  Google Scholar 

  35. Dy S. Ensuring documentation of patients’ preferences for life-sustaining treatment: brief update review. Agency for Healthcare Research and Quality; 2013.

    Google Scholar 

  36. Rietjens JAC, Sudore RL, Connolly M, van Delden JJ, Drickamer MA, Droger M, et al. Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care. Lancet Oncol. 2017;18:e543–51.

    Article  PubMed  Google Scholar 

  37. Emanuel EJ, Fairclough DL, Wolfe P, Emanuel LL. Talking with terminally ill patients and their caregivers about death, dying, and bereavement: is it stressful? Is it helpful? Arch Intern Med. 2004;164:1999–2004.

    Article  PubMed  Google Scholar 

  38. Bernacki RE, Block SD, American College of Physicians High Value Care Task Force. Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014;174:1994–2003.

    Article  PubMed  Google Scholar 

  39. Abdul-Razzak A, Heyland DK, Simon J, Ghosh S, Day AG, You JJ. Patient-family agreement on values and preferences for life-sustaining treatment: results of a multicentre observational study. BMJ Support Palliat Care. 2019;9:e20. https://doi.org/10.1136/bmjspcare-2016-001284.

    Article  PubMed  Google Scholar 

  40. Etkind SN, Bristowe K, Bailey K, Selman LE, Murtagh FE. How does uncertainty shape patient experience in advanced illness? A secondary analysis of qualitative data. Palliat Med. 2017;31:171–80.

    Article  PubMed  Google Scholar 

  41. Raiten JM, Neuman M. “If I had only known”. On choice and uncertainty in the ICU. N Engl J Med. 2012;367:1779–81.

    Article  CAS  PubMed  Google Scholar 

  42. Hjelmfors L, Sandgren A, Strömberg A, Mårtensson J, Jaarsma T, Friedrichsen M. “I was told that I would not die from heart failure”: patient perceptions of prognosis communication. Appl Nurs Res. 2018;41:41–5.

    Article  PubMed  Google Scholar 

  43. Barnato AE, Herndon MB, Anthony DL, Gallagher PM, Skinner JS, Bynum JP, et al. Are regional variations in end-of-life care intensity explained by patient preferences? A study of the US Medicare population. Med Care. 2007;45(5):386–93.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Ratcliffe JA, Wilson E, Islam S, Platsman Z, Leou K, Williams G, et al. Mortality in the coronary care unit. Coron Artery Dis. 2014;25:60–5.

    Article  PubMed  Google Scholar 

  45. Hoffmann TC, Del Mar C. Clinicians’ expectations of the benefits and harms of treatments, screening, and tests: a systematic review. JAMA Intern Med. 2017;177:407–19.

    Article  PubMed  Google Scholar 

  46. Christakis NA, Lamont EB. Extent and determinants of error in doctors’ prognoses in terminally ill patients: prospective cohort study. BMJ. 2000;320(7233):469–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Darmon M, Benoit DD, Ostermann M. Less is more: ten reasons for considering to discontinue unproven interventions. Intensive Care Med. 2019;45:1626–8.

    Article  PubMed  Google Scholar 

  48. van der Wal MHL, Hjelmfors L, Strömberg A, Jaarsma T. Cardiologists’ attitudes on communication about prognosis with heart failure patients. ESC Heart Fail. 2020; https://doi.org/10.1002/ehf2.12672. [Epub ahead of print].

  49. Piers RD, Azoulay E, Ricou B, DeKeyser GF, Max A, et al. Inappropriate care in European ICUs: confronting views from nurses and junior and senior physicians. Chest. 2014;146:267–75.

    Article  PubMed  Google Scholar 

  50. Swetz K, Mansel K. Ethical issues and palliative care in the cardiovascular intensive care unit. Cardiol Clin. 2013;31:657–68.

    Article  PubMed  Google Scholar 

  51. Dunstan GR. Hard questions in intensive care. Anaesthesia. 1985;40:479–82.

    Article  CAS  PubMed  Google Scholar 

  52. Lu E, Nakagawa S. A “Three-Stage Protocol” for serious illness conversations: reframing communication in real time. Mayo Clin Proc. 2020;95:1589–93. https://doi.org/10.1016/j.mayocp.2020.02.005.

    Article  PubMed  Google Scholar 

  53. Sulmasy D. Advance care planning and “the love song of J. Alfred Prufrock”. JAMA Intern Med. 2020;180:813–4.

    Article  PubMed  Google Scholar 

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Romanò, M. (2021). The Meanings of Prognosis: When and How to Discuss It?. In: Romanò, M. (eds) Palliative Care in Cardiac Intensive Care Units. Springer, Cham. https://doi.org/10.1007/978-3-030-80112-0_4

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  • DOI: https://doi.org/10.1007/978-3-030-80112-0_4

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