Abstract
Control processes are responsible for maintenance of the organism’s internal environment (homeostasis) and, therefore, inextricable from the very definition of living matter. Optimal homeostasis involves adaptation and relies on processing of signals from the environment. Signaling and control processes are considered that exhibit nonlinear effects such as an all-of-nothing response, switches, modulation of oscillations, and hysteresis. Examples are drawn from intracellular molecular systems, as well as multicellular and inter-organ control networks: protein kinase cascades with feedback, dynamics of the transmembrane electrochemical potential, regulation of gene expression by metabolism, and control of breathing.
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References
Arkun Y, Yasemi M (2018) Dynamics and control of the ERK signaling pathway: sensitivity, bistability, and oscillations. PLoS One 13:e0195513
Cheng S, Zaikin A (2020) Quantitative physiology. Springer, Singapore
Das J, Ho M, Zikherman J et al (2009) Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell 136:337–351
Dibrov BF, Zhabotinsky AM, Kholodenko BN (1982) Dynamic stability of steady states and static stabilization in unbranched metabolic pathways. J Math Biol 15:51–63
Fall CP, Marland ES, Wagner JM et al (eds) (2002) Computational cell biology. Springer, New York
George S, Foster JM, Richardson G (2015) Modelling in vivo action potential propagation along a giant axon. J Math Biol 70:237–263
Goldbeter A, Koshland DE Jr (1981) An amplified sensitivity arising from covalent modification in biological systems. Proc Natl Acad Sci U S A 78:6840–6844
Haberichter T, Marhl M, Heinrich R (2001) Birhythmicity, trirhythmicity and chaos in bursting calcium oscillations. Biophys Chem 90:17–30
Hansel D, Mato G, Meunier C (1993) Phase dynamics for weakly coupled Hodgkin-Huxley neurons. Europhys Lett 23:367–372
Hess B, Boiteux A (1971) Oscillatory phenomena in biochemistry. Annu Rev Biochem 40:237–258
Hiratsuka T, Fujita Y, Naoki H et al (2015) Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. elife 4:e05178
Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500–544
Huang CYF, Ferrell JE Jr (1996) Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 93:10078–10083
Jacob F, Perrin D, Sanchez C et al (1960) Operon: a group of genes with the expression coordinated by an operator. C R Hebd Seances Acad Sci 250:1727–1729
Kholodenko BN (2000) Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur J Biochem 267:1583–1588
Maly IV, Hofmann WA (2016) Calcium-regulated import of myosin IC into the nucleus. Cytoskeleton 73:341–350
Maly IV, Hofmann WA (2018) Calcium and nuclear signaling in prostate cancer. Int J Mol Sci 19:1237
Maly IV, Hofmann WA (2020) Myosins in the nucleus. In: Coluccio L (ed) Myosins, Advances in experimental medicine and biology, vol 1239. Springer, Cham, pp 199–231
Maly IV, Lee RT, Lauffenburger DA (2004a) A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling. Ann Biomed Eng 32:1319–1335
Maly IV, Wiley HS, Lauffenburger DA (2004b) Self-organization of polarized cell signaling via autocrine circuits: computational model analysis. Biophys J 86:10–22
Molkov YI, Shevtsova NA, Park C et al (2014) A closed-loop model of the respiratory system: focus on hypercapnia and active expiration. PLoS One 9:e109894
Molkov YI, Rubin JE, Rybak IA et al (2017) Computational models of the neural control of breathing. Wiley Interdiscip Rev Syst Biol Med 9:e1371
Muller L, Chavane F, Reynolds J et al (2018) Cortical travelling waves: mechanisms and computational principles. Nat Rev Neurosci 19:255–268
Nakayama K, Satoh T, Igari A et al (2008) FGF induces oscillations of Hes1 expression and Ras/ERK activation. Curr Biol 18:R332–R334
Novak B, Tyson JJ (1993) Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos. J Cell Sci 106:1153–1168
Russell DF (1986) Respiratory pattern generation in adult lampreys (Lampetra fluviatilis): interneurons and burst resetting. J Comp Physiol A 158:91–102
Santillán M, Mackey MC (2008) Quantitative approaches to the study of bistability in the lac operon of Escherichia coli. J R Soc Interface 5:S29–S39
Santillán M, Mackey MC, Zeron ES (2007) Origin of bistability in the lac operon. Biophys J 92:3830–3842
Shin SY, Rath O, Choo SM et al (2009) Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci 122:425–435
Tschumperlin DJ, Dai G, Maly IV et al (2004) Mechanotransduction through growth-factor shedding into the extracellular space. Nature 429:83–86
Yildirim N, Santillán M, Horike D et al (2004) Dynamics and bistability in a reduced model of the lac operon. Chaos 14:279–292
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Maly, I. (2021). Signaling and Control. In: Quantitative Elements of General Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-79146-9_4
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DOI: https://doi.org/10.1007/978-3-030-79146-9_4
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