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Mechanical and Functional Interdependence Between the RV and LV

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The Right Heart

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Abstract

The function and mechanics of the left and right ventricles are closely intertwined. In normal physiology, the left ventricle (LV) substantially contributes to right ventricular (RV) pressure development and output. Thus, it can be expected that when LV function is impaired, RV function will be impacted. In normal physiology, the RV has a much lesser effect on the LV. However, the pressure-loaded, volume-loaded, or dyssynchronous RV can profoundly impact LV systolic and diastolic function. These interactions have important clinical implications and the presence of RV dysfunction in “left-heart” disease impacts outcomes. Likewise, concomitant LV dysfunction in “right-heart” disease worsens prognosis. Thus RV-LV interactions are important to understand. Moreover, leveraging of these interactions can be used to treat various diseases.

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  1. Division of Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, ON, Canada

    Mark K. Friedberg

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  1. National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital, Dublin, Ireland

    Sean P. Gaine

  2. Free University of Brussels, Brussels, Belgium

    Robert Naeije

  3. Scottish Pulmonary Vascular Unit, Regional Heart and Lung Centre, Glasgow, UK

    Andrew J. Peacock

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Friedberg, M.K. (2021). Mechanical and Functional Interdependence Between the RV and LV. In: Gaine, S.P., Naeije, R., Peacock, A.J. (eds) The Right Heart. Springer, Cham. https://doi.org/10.1007/978-3-030-78255-9_4

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  • DOI: https://doi.org/10.1007/978-3-030-78255-9_4

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