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Drugs Resistance Management

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Biochemistry of Drug Resistance

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Abstract

Drug resistance is affecting people worldwide. Drug resistance reduces the efficiency of medicine incurring a disease. An antibiotic resistance results from overuse of antibiotic in bacterial infections. In designing the drug, understanding of underlying antibiotic resistance factors is important which may include inactivation by specific enzymes, alternation in target site or metabolic pathways and reduction in the accumulation of drug molecules. It usually develops when microbes multiply and find route of fighting out drug molecules. Other reasons may include attitude towards the prescription, carelessness in precautions employed for infections, and lack of attention of both government and patients. Resistance can be combated using specific enzymes in activating the resistant genes. Surgery or medicinal intake controls antibiotic resistance in HIV. Vaccines also manage sensitivity of microbes to the drug. Generations of antibiotics are needed which recognize pathogen-associated molecular pathways (PAMPS). Alternations in drugs dosage or utilizing drugs combinations increase the efficacy of treatment. Drug resistance mechanisms must therefore be controlled for preventing the spread of many acute diseases.

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Authors and Affiliations

  1. Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan

    Nabila Bashir, Saima Ashraf, Nadia Rashid, Syed Tayyab Raza Naqvi, Saadat Majeed, Muhammad Naeem Ashiq & Muhammad Najam-ul-Haq

  2. Department of Pharmacy, COMSATS University Islamabad (CUI), Lahore Campus, Lahore, Pakistan

    Ghulam Murtaza

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  1. Nabila Bashir
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  2. Saima Ashraf
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  3. Nadia Rashid
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  4. Syed Tayyab Raza Naqvi
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  5. Saadat Majeed
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  6. Ghulam Murtaza
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  7. Muhammad Naeem Ashiq
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  8. Muhammad Najam-ul-Haq
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Correspondence to Muhammad Najam-ul-Haq .

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Editors and Affiliations

  1. Department of Basic Sciences, University of Veterinary and Animal Sciences, Narowal, Pakistan

    Sarfraz Ahmed

  2. Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, China

    Suvash Chandra Ojha

  3. Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan

    Muhammad Najam-ul-Haq

  4. Department of Pathobiology, University of Veterinary and Animal Sciences, Narowal, Pakistan

    Muhammad Younus

  5. Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan

    Muhammad Zaffar Hashmi

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Bashir, N. et al. (2021). Drugs Resistance Management. In: Ahmed, S., Chandra Ojha, S., Najam-ul-Haq, M., Younus, M., Hashmi, M.Z. (eds) Biochemistry of Drug Resistance. Springer, Cham. https://doi.org/10.1007/978-3-030-76320-6_21

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