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Enhancing In Vitro Bioavailability of Berberine by Incorporation of Beta–Cyclodextrin Complex into Solid Dispersion System

  • Conference paper
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8th International Conference on the Development of Biomedical Engineering in Vietnam (BME 2020)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 85))

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Abstract

Berberine is widely used in Eastern countries thanks to low cost and various biological activities. However, low solubility has limited its bioavailability. The purpose of this study is to prepare and evaluate solid dispersion loading berberine—β-cyclodextrin complex to improve the effective treatment of berberine. Two techniques, inclusion complex and solid dispersion, are applied to increase the bioavailability of berberine for further applications. The inclusion complex is prepared by grinding berberine and β-cyclodextrin with various ratios. Solid dispersion loading berberine—β-cyclodextrin complex is fabricated from polyethylene glycol (PEG 6000) by melting completely and then spray-drying with lactose for powder formation. The complex and solid dispersion is evaluated about solubility and drug release in distilled water. Moreover, the final product is also analyzed with powder X-ray diffraction (PXRD). As a result, the complex which has ratio 1:1 between berberine and β-cyclodextrin expresses the highest solubility and optimal dissolution profiles in distilled water in comparison with pure berberine. Solid dispersion samples show many advantages in solubility and dissolution rate compared to pure berberine; the solubility reaches nearly three times over pure berberine. The results of the sample of incorporation of the β-cyclodextrin complex into solid dispersion have significant improvement compared to pure berberine. In general, solid dispersion containing berberine β-cyclodextrin complex expresses the considerable enhancement in vitro bioavailability of berberine. Hence, it could be applied as a promising system for improving the therapeutic treatment of berberine.

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Acknowledgements

This research is funded by International University, Vietnam National University, Ho Chi Minh City (VNU-HCMC) under grant number SV2019-BME-10 /HĐ-KHCN.

This research is funded by Vietnam National University HoChiMinh City (VNU-HCM) under grant number NCM2020-28-01.

Conflicts of Interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Pharmaceutical Engineering Lab, School of Biomedical Engineering, International University—Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

    Hang Thu Than, Thuy Phan-Quoc Nguyen, Phat Dong Le, Phi Hong Tran & Van Hong Nguyen

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  1. Hang Thu Than
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  2. Thuy Phan-Quoc Nguyen
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  3. Phat Dong Le
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  4. Phi Hong Tran
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  5. Van Hong Nguyen
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Correspondence to Van Hong Nguyen .

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Editors and Affiliations

  1. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Vo Van Toi

  2. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Thi-Hiep Nguyen

  3. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Vong Binh Long

  4. School of Biomedical Engineering, International University—Vietnam National Universities, Ho Chi Minh, Vietnam

    Ha Thi Thanh Huong

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Than, H.T., Nguyen, T.PQ., Dong Le, P., Tran, P.H., Nguyen, V.H. (2022). Enhancing In Vitro Bioavailability of Berberine by Incorporation of Beta–Cyclodextrin Complex into Solid Dispersion System. In: Van Toi, V., Nguyen, TH., Long, V.B., Huong, H.T.T. (eds) 8th International Conference on the Development of Biomedical Engineering in Vietnam. BME 2020. IFMBE Proceedings, vol 85. Springer, Cham. https://doi.org/10.1007/978-3-030-75506-5_24

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  • DOI: https://doi.org/10.1007/978-3-030-75506-5_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-75505-8

  • Online ISBN: 978-3-030-75506-5

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