Abstract
In defiance of substantial progress in the production of a broad range of cancer delivery systems based on nanocarriers remain unattached to many prevailing problems, such as the aggressive battle against cancer multidrug resistance (MDR) and the low penetration efficiency of the supply systems. In recent years, the production of new metal-based nanomaterials and their use in biomedicine has received considerable attention. Important progress has been made as metal-based nanomaterials with regulated geometry, physicochemical characteristics and surface load, and bioactive polymers have been synthesised. These fruitful activities have led to greater biocompatibility and an active focus on a tumour tissue, which has led to the development of a variety of nanomaterials that can diagnose cancers, supply anticancer medicines and kill tumours through a number of therapeutic procedures. This book chapter is intended to provide an overview of the metal-based nanomaterials developed to identify and treat different forms of cancer and to illustrate the emergent possibilities for metal-based nanomaterials used in anticancer treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Murray, F. J., Monnot, A. D., Jacobson-Kram, D., et al. (2020). A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential. Regulatory Toxicology and Pharmacology, 104801.
Fan, Z., Fu, P. P., Yu, H., et al. (2014). Theranostic nanomedicine for cancer detection and treatment. Journal of Food and Drug Analysis, 3–17.
Li, Y., Gao, Y., Zhang, X., et al. (2020). Nanoparticles in precision medicine for ovarian cancer: From chemotherapy to immunotherapy. International Journal of Pharmaceutics, 119986.
Fadeel, B., & Alexiou, C. (2020). Brave new world revisited: Focus on nanomedicine. Biochemical and Biophysical Research Communications, 533, 36–49. Available from: http://www.sciencedirect.com/science/article/pii/S0006291X20316429.
Wu, P., Zhang, B., Ocansey, D. K. W., et al. (2020). Extracellular vesicles: A bright star of nanomedicine. Biomaterials, 120467. Available from: http://www.sciencedirect.com/science/article/pii/S0142961220307134.
Shetty, A., & Chandra, S. (2020). Inorganic hybrid nanoparticles in cancer theranostics: Understanding their combinations for better clinical translation. Materials Today Chemistry, 18, 100381. Available from: http://www.sciencedirect.com/science/article/pii/S2468519420301415.
Chen, H.-Y., Deng, J., Wang, Y., et al. (2020). Hybrid cell membrane-coated nanoparticles: A multifunctional biomimetic platform for cancer diagnosis and therapy. Acta Biomaterialia, 112, 1–13. Available from: http://www.sciencedirect.com/science/article/pii/S1742706120302981.
Ghitman, J., Biru, E. I., Stan, R., et al. (2020). Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine. Materials and Design, 193, 108805. Available from: http://www.sciencedirect.com/science/article/pii/S0264127520303397
Andrade, K. N., Pérez, A. M. P., & Arízaga, G. G. C. (2019). Passive and active targeting strategies in hybrid layered double hydroxides nanoparticles for tumor bioimaging and therapy. Applied Clay Science, 181, 105214. Available from: http://www.sciencedirect.com/science/article/pii/S0169131719302728
Ferreira Soares, D. C., Domingues, S. C., Viana, D. B., et al. (2020). Polymer-hybrid nanoparticles: Current advances in biomedical applications. Biomedicine & Pharmacotherapy, 131, 110695. Available from: http://www.sciencedirect.com/science/article/pii/S075333222030888X
Liu, Y., Meng, X., & Bu, W. (2019). Upconversion-based photodynamic cancer therapy. Coordination Chemistry Reviews, 379, 82–98. Available from: http://www.sciencedirect.com/science/article/pii/S001085451730351X
Thorat, N. D., Townley, H. E., Patil, R. M., et al. (2020). Comprehensive approach of hybrid nanoplatforms in drug delivery and theranostics to combat cancer. Drug Discovery Today, 25, 1245–1252. Available from: http://www.sciencedirect.com/science/article/pii/S1359644620301665
Cheng, Y., Jiao, X., Fan, W., et al. (2020). Controllable synthesis of versatile mesoporous organosilica nanoparticles as precision cancer theranostics. Biomaterials [Internet], 256, 120191. Available from: http://www.sciencedirect.com/science/article/pii/S0142961220304373
Ghazy, E., Kumar, A., Barani, M., et al. (2020). Scrutinizing the therapeutic and diagnostic potential of nanotechnology in thyroid cancer: Edifying drug targeting by nano-oncotherapeutics. Journal of Drug Delivery Science and Technology, 17, 102221. Available from: http://www.sciencedirect.com/science/article/pii/S1773224720315100
Barani, M., Bilal, M., Sabir, F., et al. (2021). Nanotechnology in ovarian cancer: Diagnosis and treatment. Life Sciences, 266, 118914. Available from: http://www.sciencedirect.com/science/article/pii/S0024320520316738
Sharma, S., Kumari, R., Varshney, S. K., et al. (2020). Optical biosensing with electromagnetic nanostructures. Physical Review, 5, 100044. Available from: http://www.sciencedirect.com/science/article/pii/S2405428320300071
Ranjan, P., Parihar, A., Jain, S., et al. (2020). Biosensor-based diagnostic approaches for various cellular biomarkers of breast cancer: A comprehensive review. Analytical Biochemistry, 610, 113996. Available from: http://www.sciencedirect.com/science/article/pii/S0003269720305285
Dar, G. I., Zubair Iqbal, M., & Wu, A. (2019). Multifunctional biocompatible Janus nanostructures for biomedical applications. Current Opinion in Biomedical Engineering, 10, 79–88. Available from: http://www.sciencedirect.com/science/article/pii/S2468451119300017
Zhang, D., Yang, Z., Yu, S., et al. (2020). Diversiform metal oxide-based hybrid nanostructures for gas sensing with versatile prospects. Coordination Chemistry Reviews, 413, 213272. Available from: http://www.sciencedirect.com/science/article/pii/S0010854520300904
Dhas, N., Kudarha, R., Garkal, A., et al. (2021). Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs. Journal of Controlled Release, 330, 257–283. Available from: http://www.sciencedirect.com/science/article/pii/S0168365920307392
Nandini, D. B., Rao, R. S., Hosmani, J., et al. (2020). Novel therapies in the management of oral cancer: An update. Disease-a-Month, 66, 101036. Available from: http://www.sciencedirect.com/science/article/pii/S0011502920300985
Wooster, A. L., Girgis, L. H., Brazeale, H., et al. (2021). Dendritic cell vaccine therapy for colorectal cancer. Pharmacological Research, 164, 105374. Available from: http://www.sciencedirect.com/science/article/pii/S1043661820316820
Das, S. S., Alkahtani, S., Bharadwaj, P., et al. (2020a). Molecular insights and novel approaches for targeting tumor metastasis. International Journal of Pharmaceutics, 585, 119556. Available from: http://www.sciencedirect.com/science/article/pii/S0378517320305408
Levitzki, A., & Klein, S. (2010). Signal transduction therapy of cancer. Molecular Aspects of Medicine, 31, 287–329. Available from: http://www.sciencedirect.com/science/article/pii/S0098299710000348
Teates, C. D., & Parekh, J. S. (1993). New radiopharmaceuticals and new applications in medicine. Current Problems in Diagnostic Radiology, 22, 231–266. Available from: http://www.sciencedirect.com/science/article/pii/036301889390013J
Allan, N., Siller, C., & Breen, A. (2012). Anaesthetic implications of chemotherapy. Continuing Education in Anesthesia, Critical Care and Pain, 12, 52–56. Available from: http://www.sciencedirect.com/science/article/pii/S1743181617301695
Tewari, D., Rawat, P., & Singh, P. K. (2019). Adverse drug reactions of anticancer drugs derived from natural sources. Food and Chemical Toxicology, 123, 522–535. Available from: http://www.sciencedirect.com/science/article/pii/S0278691518308433
Adelberg, D. E., & Bishop, M. R. (2009). Emergencies related to cancer chemotherapy and hematopoietic stem cell transplantation. Emergency Medicine Clinics of North America, 27, 311–331. Available from: http://www.sciencedirect.com/science/article/pii/S0733862709000170
Imran, M., Das, K. R., & Naik, M. M. (2019). Co-selection of multi-antibiotic resistance in bacterial pathogens in metal and microplastic contaminated environments: An emerging health threat. Chemosphere, 215, 846–857. Available from: http://www.sciencedirect.com/science/article/pii/S0045653518319751
Thorat, N. D., & Bauer, J. (2020). Functional smart hybrid nanostructures based nanotheranostic approach for advanced cancer treatment. Applied Surface Science, 527, 146809. Available from: http://www.sciencedirect.com/science/article/pii/S016943322031566X
Xiao, S., & Chen, L. (2020). The emerging landscape of nanotheranostic-based diagnosis and therapy for osteoarthritis. Journal of Controlled Release, 328, 817–833. Available from: http://www.sciencedirect.com/science/article/pii/S0168365920306568
Prasad, R., Jain, N. K., Conde, J., et al. (2020). Localized nanotheranostics: Recent developments in cancer nanomedicine. Materials Today Advances, 8, 100087. Available from: http://www.sciencedirect.com/science/article/pii/S2590049820300345
Malla, R. R., Kumari, S., Kgk, D., et al. (2020). Nanotheranostics: Their role in hepatocellular carcinoma. Critical Reviews in Oncology/Hematology, 151, 102968. Available from: http://www.sciencedirect.com/science/article/pii/S1040842820301062
Mottaghitalab, F., Farokhi, M., Fatahi, Y., et al. (2019). New insights into designing hybrid nanoparticles for lung cancer: Diagnosis and treatment. Journal of Controlled Release, 295, 250–267. Available from: http://www.sciencedirect.com/science/article/pii/S0168365919300276
Cazares-Cortes, E., Cabana, S., Boitard, C., et al. (2019). Recent insights in magnetic hyperthermia: From the “hot-spot” effect for local delivery to combined magneto-photo-thermia using magneto-plasmonic hybrids. Advanced Drug Delivery Reviews, 138, 233–246. Available from: http://www.sciencedirect.com/science/article/pii/S0169409X18302849f
Rawal, S., & Patel, M. M. (2019). Threatening cancer with nanoparticle aided combination oncotherapy. Journal of Controlled Release, 301, 76–109. Available from: http://www.sciencedirect.com/science/article/pii/S0168365919301646
Lagopati, N., Evangelou, K., Falaras, P., et al. (2021). Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent. Pharmacology & Therapeutics, 222, 107795. Available from: http://www.sciencedirect.com/science/article/pii/S0163725820303260
Hatami, E., Jaggi, M., Chauhan, S. C., et al. (1874). Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics. Biochimica et Biophysica Acta – Reviews on Cancer, 2020, 188381. Available from: http://www.sciencedirect.com/science/article/pii/S0304419X20301001
Pereira-Silva, M., Alvarez-Lorenzo, C., Concheiro, A., et al. (2020). Nanomedicine in osteosarcoma therapy: Micelleplexes for delivery of nucleic acids and drugs toward osteosarcoma-targeted therapies. European Journal of Pharmaceutics and Biopharmaceutics, 148, 88–106. Available from: http://www.sciencedirect.com/science/article/pii/S0939641120300175
Bueloni, B., Sanna, D., Garribba, E., et al. (2020). Design of nalidixic acid-vanadium complex loaded into chitosan hybrid nanoparticles as smart strategy to inhibit bacterial growth and quorum sensing. International Journal of Biological Macromolecules, 161, 1568–1580. Available from: http://www.sciencedirect.com/science/article/pii/S0141813020340630
Natesan, S., Ponnusamy, C., Sugumaran, A., et al. (2017). Artemisinin loaded chitosan magnetic nanoparticles for the efficient targeting to the breast cancer. International Journal of Biological Macromolecules, 104, 1853–1859. Available from: https://www.sciencedirect.com/science/article/pii/S0141813016327222
Peng, H., Hu, C., Hu, J., et al. (2016). Fe3O4@mZnO nanoparticles as magnetic and microwave responsive drug carriers. Microporous Mesoporous Mater. [Internet]., 226, 140–145. Available from: https://www.sciencedirect.com/science/article/pii/S1387181115007179
Panda, J., Satapathy, B. S., Majumder, S., et al. (2019). Engineered polymeric iron oxide nanoparticles as potential drug carrier for targeted delivery of docetaxel to breast cancer cells. Journal of Magnetism and Magnetic Materials, 485, 165–173. Available from: https://www.sciencedirect.com/science/article/pii/S0304885318327185
Saxena, N., Agraval, H., Barick, K. C., et al. (2020). Thermal and microwave synthesized SPIONs: Energy effects on the efficiency of nano drug carriers. Materials Science and Engineering: C, 111, 110792. Available from: https://www.sciencedirect.com/science/article/pii/S0928493119340068
Karthika, V., Kaleeswarran, P., Gopinath, K., et al. (2018). Biocompatible properties of nano-drug carriers using TiO2-Au embedded on multiwall carbon nanotubes for targeted drug delivery. Materials Science and Engineering: C, 90, 589–601. Available from: https://www.sciencedirect.com/science/article/pii/S0928493117334173
Fatematossadat, P. A., Mohammadi, M., & Roozmeh, S. E. (2019). Fe@(Au/Ag)n (n=1,12,54) core-shell nanoparticles as effective drug delivery vehicles for anti-cancer drugs: The computational study. Journal of Molecular Graphics and Modelling [Internet]., 90, 33–41. Available from: https://www.sciencedirect.com/science/article/pii/S1093326319300257
Usman, M. S., Hussein, M. Z., Kura, A. U., et al. (2020). Chlorogenic acid intercalated Gadolinium–Zinc/Aluminium layered double hydroxide and gold nanohybrid for MR imaging and drug delivery. Materials Chemistry and Physics [Internet], 240, 122232. Available from: https://www.sciencedirect.com/science/article/pii/S0254058419310478
Kankala, R. K., Liu, C.-G., Yang, D.-Y., et al. (2020). Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance. Chemical Engineering Journal, 383, 123138. Available from: http://www.sciencedirect.com/science/article/pii/S1385894719325501
Sinha, B. K., Perera, L., & Cannon, R. E. (2019). Reversal of drug resistance by JS-K and nitric oxide in ABCB1- and ABCG2-expressing multi-drug resistant human tumor cells. Biomedicine & Pharmacotherapy, 120, 109468. Available from: http://www.sciencedirect.com/science/article/pii/S0753332219331464
Miller, E. M., Samec, T. M., & Alexander-Bryant, A. A. (2021). Nanoparticle delivery systems to combat drug resistance in ovarian cancer. Nanomedicine: Nanotechnology, Biology and Medicine, 31, 102309. Available from: http://www.sciencedirect.com/science/article/pii/S1549963420301635
Sun, D., Lu, J., Zhang, L., et al. (2019). Aptamer-based electrochemical cytosensors for tumor cell detection in cancer diagnosis: A review. Analytica Chimica Acta, 1082, 1–17. Available from: http://www.sciencedirect.com/science/article/pii/S0003267019308785
Prasher, P., Sharma, M., Mudila, H., et al. (2020). Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery. Colloid and Interface Science Communications, 35, 100244. Available from: http://www.sciencedirect.com/science/article/pii/S2215038220300248
Zhou, G., Latchoumanin, O., Hebbard, L., et al. (2018a). Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers. Advanced Drug Delivery Reviews, 134, 107–121. Available from: http://www.sciencedirect.com/science/article/pii/S0169409X18300577
Zhou, Z., Liu, M., & Jiang, J. (2018b). The potential of aptamers for cancer research. Analytical Biochemistry, 549, 91–95. Available from: http://www.sciencedirect.com/science/article/pii/S0003269718302641
Anoop, V., Cutinho, L. I., Mourya, P., et al. (2020). Approaches for encephalic drug delivery using nanomaterials: The current status. Brain Research Bulletin, 155, 184–190. Available from: http://www.sciencedirect.com/science/article/pii/S036192301830950X
Alfaifi, A. A., Heyder, R. S., Bielski, E. R., et al. (2020). Megalin-targeting liposomes for placental drug delivery. Journal of Controlled Release, 324, 366–378. Available from: http://www.sciencedirect.com/science/article/pii/S0168365920303102
Badıllı, U., Mollarasouli, F., Bakirhan, N. K., et al. (2020). Role of quantum dots in pharmaceutical and biomedical analysis, and its application in drug delivery. TrAC Trends in Analytical Chemistry, 131, 116013. Available from: http://www.sciencedirect.com/science/article/pii/S0165993620302429
Du, J., Shi, T., Long, S., et al. (2021). Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation. Coordination Chemistry Reviews, 427, 213604. Available from: http://www.sciencedirect.com/science/article/pii/S0010854520307189
Wang, H., Guo, Y., Wang, C., et al. (2021). Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia. Biomaterials, 269, 120621. Available from: http://www.sciencedirect.com/science/article/pii/S0142961220308681
Janas, K., Boniewska-Bernacka, E., Dyrda, G., et al. (2021). Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer. Bioorganic & Medicinal Chemistry, 30, 115926. Available from: http://www.sciencedirect.com/science/article/pii/S0968089620307562
Yi, C., Yu, Z., Ren, Q., et al. (2020). Nanoscale ZnO-based photosensitizers for photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 30, 101694. Available from: http://www.sciencedirect.com/science/article/pii/S1572100020300478
Wu, C., Li, D., Wang, L., et al. (2017). Single wavelength light-mediated, synergistic bimodal cancer photoablation and amplified photothermal performance by graphene/gold nanostar/photosensitizer theranostics. Acta Biomaterialia, 53, 631–642. Available from: http://www.sciencedirect.com/science/article/pii/S1742706117300879
Yang, K., Zhang, S., He, J., et al. (2021). Polymers and inorganic nanoparticles: A winning combination towards assembled nanostructures for cancer imaging and therapy. Nano Today, 36, 101046. Available from: http://www.sciencedirect.com/science/article/pii/S1748013220302164
Beik, J., Khateri, M., Khosravi, Z., et al. (2019). Gold nanoparticles in combinatorial cancer therapy strategies. Coordination Chemistry Reviews, 387, 299–324. Available from: http://www.sciencedirect.com/science/article/pii/S0010854518305393
Su, Y., Wang, N., Liu, B., et al. (2020). A phototheranostic nanoparticle for cancer therapy fabricated by BODIPY and graphene to realize photo-chemo synergistic therapy and fluorescence/photothermal imaging. Dyes and Pigments, 177, 108262. Available from: http://www.sciencedirect.com/science/article/pii/S0143720819323782
Das, P., Mudigunda, S. V., Darabdhara, G., et al. (2020b). Biocompatible functionalized AuPd bimetallic nanoparticles decorated on reduced graphene oxide sheets for photothermal therapy of targeted cancer cells. Journal of Photochemistry and Photobiology B: Biology, 212, 112028. Available from: http://www.sciencedirect.com/science/article/pii/S1011134420304784
Deepa, N. B., & Pundir, C. S. (2020). An electrochemical CD59 targeted noninvasive immunosensor based on graphene oxide nanoparticles embodied pencil graphite for detection of lung cancer. Microchemical Journal, 156, 104957. Available from: http://www.sciencedirect.com/science/article/pii/S0026265X20301831
Alemi, F., Zarezadeh, R., Sadigh, A. R., et al. (2020). Graphene oxide and reduced graphene oxide: Efficient cargo platforms for cancer theranostics. Journal of Drug Delivery Science and Technology, 60, 101974. Available from: http://www.sciencedirect.com/science/article/pii/S1773224720312636
Mehra, N. K., & Jain, N. K. (2016). Multifunctional hybrid-carbon nanotubes: New horizon in drug delivery and targeting. Journal of Drug Targeting, 294–308.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Manikandan, S., Subbaiya, R., Saravanan, M., Barabadi, H., Arulvel, R. (2021). Emerging Theragnostic Metal-Based Nanomaterials to Combat Cancer. In: Saravanan, M., Barabadi, H. (eds) Cancer Nanotheranostics. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-74330-7_11
Download citation
DOI: https://doi.org/10.1007/978-3-030-74330-7_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-74329-1
Online ISBN: 978-3-030-74330-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)