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Assessing Disease Severity and Prognosis

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Elastography of the Liver and Beyond

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Abstract

The ability of identifying those patients at highest risk of developing clinical decompensation and hepatocellular carcinoma and at higher risk of death is key in clinical practice. Among patients with compensated advanced chronic liver disease (cACLD), risk stratification can take advantage of liver and spleen stiffness measurement. Liver stiffness measurement (LSM) has proven a robust predictor of clinical events in patients with cACLD, even beyond the identification of those with clinically significant portal hypertension. This chapter summarizes the existing data regarding the prognostic ability of liver stiffness and spleen stiffness measured by different ultrasound elastography techniques for predicting clinical decompensation, hepatocellular carcinoma and death in patients with cACLD.

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Acknowledgement

Financial Support: Élise Vuille-Lessard is supported by a Clinical Hepatology Fellowship of the Canadian Association for the Study of the Liver (CASL-CLF 2020–2021). Ahmed Y. Elmahdy is supported by a Swiss Government Excellence Scholarship (ESKAS 2019.0832).

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  1. Hepatology, University Clinic for Visceral Surgery and Medicine (UVCM), Inselspital, University Hospital of Bern, University of Bern, Berne, Switzerland

    Élise Vuille-Lessard, Ahmed Y. Elmahdy & Annalisa Berzigotti

  2. Department of Biomedical Research (DBMR), University of Bern, Berne, Switzerland

    Élise Vuille-Lessard, Ahmed Y. Elmahdy & Annalisa Berzigotti

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  1. Élise Vuille-Lessard
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Correspondence to Annalisa Berzigotti .

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  1. Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Mirella Fraquelli

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Vuille-Lessard, É., Elmahdy, A.Y., Berzigotti, A. (2021). Assessing Disease Severity and Prognosis. In: Fraquelli, M. (eds) Elastography of the Liver and Beyond. Springer, Cham. https://doi.org/10.1007/978-3-030-74132-7_12

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